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  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
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  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 3. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzoic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Nitrobenzoic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Overview of Methyl 2-Methyl-4-Nitro-Benzoate (CAS No. 62621-09-4): Properties, Applications, and Industry Insights

Methyl 2-methyl-4-nitro-benzoate (CAS No. 62621-09-4) is a specialized organic compound widely recognized for its versatile applications in pharmaceuticals, agrochemicals, and fine chemical synthesis. This ester derivative, characterized by its nitro and methyl ester functional groups, serves as a critical intermediate in the synthesis of complex molecules. Its molecular formula, C₉H₉NO₄, and structural features make it a subject of interest for researchers and industrial chemists alike.

In recent years, the demand for nitroaromatic compounds like methyl 2-methyl-4-nitro-benzoate has surged due to their role in developing active pharmaceutical ingredients (APIs) and crop protection agents. The compound’s electron-withdrawing nitro group enhances reactivity in nucleophilic substitution reactions, a property leveraged in drug discovery pipelines. Notably, its stability under controlled conditions aligns with green chemistry principles, a trending topic in sustainable manufacturing.

The synthesis of methyl 2-methyl-4-nitro-benzoate typically involves the esterification of 2-methyl-4-nitrobenzoic acid with methanol, catalyzed by acidic or enzymatic methods. Innovations in catalytic processes and solvent-free reactions have optimized its production, addressing environmental concerns raised in chemical industry forums. Analytical techniques such as HPLC and NMR spectroscopy ensure high purity, meeting stringent regulatory standards for pharmaceutical intermediates.

Beyond pharmaceuticals, this compound finds utility in dye synthesis and material science. Its nitro-aromatic backbone contributes to UV-absorbing properties, making it valuable in polymer stabilizers and sunscreen formulations. Researchers are also exploring its potential in organic electronics, where its molecular structure could enhance charge transport in semiconducting materials.

Frequently asked questions about CAS No. 62621-09-4 include inquiries about its solubility profile (soluble in organic solvents like ethanol and acetone), storage conditions (recommended at 2–8°C in airtight containers), and handling precautions (standard lab PPE suffices). These details are critical for laboratories prioritizing chemical safety and operational efficiency.

The global market for methyl 2-methyl-4-nitro-benzoate is projected to grow, driven by advancements in generic drug manufacturing and agrochemical innovation. Suppliers emphasize batch-to-batch consistency and regulatory compliance, key factors for buyers sourcing high-purity intermediates. As industries pivot toward bio-based alternatives, the compound’s synthetic efficiency ensures its relevance in traditional and emerging sectors.

In summary, methyl 2-methyl-4-nitro-benzoate (CAS No. 62621-09-4) exemplifies the intersection of chemical versatility and industrial applicability. Its role in API synthesis, coupled with evolving applications in advanced materials, positions it as a compound of enduring significance. Ongoing research into catalytic optimization and sustainable production methods will further solidify its standing in the chemical landscape.

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