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• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Introduction to N-(4-Iodophenyl)acetamide (CAS No. 622-50-4)

N-(4-Iodophenyl)acetamide, with the chemical formula C₈H₇INO, is a significant compound in the realm of pharmaceutical and biochemical research. This compound, identified by its CAS number 622-50-4, has garnered considerable attention due to its versatile applications in synthetic chemistry and drug development. The presence of an iodine atom at the para position of the phenyl ring and the acetamide functional group makes it a valuable intermediate in various chemical transformations.

The structural features of N-(4-Iodophenyl)acetamide contribute to its reactivity, making it a preferred choice for researchers exploring novel synthetic pathways. The iodine substituent facilitates various coupling reactions, including Suzuki-Miyaura and Sonogashira couplings, which are pivotal in constructing complex molecular architectures. Additionally, the acetamide group can undergo further modifications, such as hydrolysis or amidation, to yield diverse derivatives with tailored biological activities.

In recent years, N-(4-Iodophenyl)acetamide has been extensively studied for its potential in medicinal chemistry. Its incorporation into pharmacophores has led to the development of novel compounds with therapeutic implications. For instance, researchers have explored its use in designing kinase inhibitors, which are crucial in treating various cancers and inflammatory diseases. The iodine atom serves as a handle for further functionalization, enabling the creation of highly specific inhibitors targeting disease-causing enzymes.

Moreover, the compound has found applications in materials science, particularly in the synthesis of organic semiconductors and luminescent materials. The electron-withdrawing nature of the acetamide group and the presence of the iodine atom contribute to its ability to form stable conjugated systems, which are essential for optoelectronic applications. Recent studies have demonstrated its role in developing organic light-emitting diodes (OLEDs) and photovoltaic cells, highlighting its importance beyond pharmaceuticals.

The synthesis of N-(4-Iodophenyl)acetamide typically involves the reaction of 4-iodobenzoyl chloride with ammonia or ammonium hydroxide. This straightforward approach yields the desired product with high purity, making it readily accessible for further applications. However, researchers have also explored alternative synthetic routes to optimize yield and minimize byproducts. For example, catalytic methods using transition metals have been investigated to enhance the efficiency of the reaction.

Recent advancements in computational chemistry have further expanded the utility of N-(4-Iodophenyl)acetamide. Molecular modeling studies have provided insights into its interactions with biological targets, aiding in the rational design of drug candidates. These simulations have revealed that the compound can effectively bind to proteins involved in metabolic pathways, suggesting its potential as an antimicrobial agent. Such findings underscore the importance of computational tools in modern drug discovery.

The safety profile of N-(4-Iodophenyl)acetamide is another critical aspect that has been thoroughly evaluated. While it is not classified as a hazardous material under standard regulatory guidelines, proper handling procedures must be followed to ensure safe laboratory practices. Researchers should adhere to established protocols for handling organic compounds, including personal protective equipment (PPE) and adequate ventilation.

In conclusion, N-(4-Iodophenyl)acetamide (CAS No. 622-50-4) is a multifaceted compound with significant applications in pharmaceuticals and materials science. Its unique structural features enable diverse chemical transformations and biological activities, making it a valuable tool for researchers across various disciplines. As our understanding of its properties continues to evolve, so too will its applications in advancing scientific knowledge and technological innovation.

• 19230-45-6(N-(3-Iodophenyl)acetamide)
• 123765-71-9(Acetamide,N-(4-iodo-3,5-dimethylphenyl)-)
• 90585-26-5(Acetamide, N-(2-iodophenyl)-N-methyl-)
• 62404-60-8(Acetamide, N-(3-iodophenyl)-N-methyl-)
• 62404-59-5(Acetamide, N-(4-iodophenyl)-N-methyl-)
• 2564-00-3(2-Chloro-N-(4-Iodophenyl)Acetamide)
• 2564-01-4(2-chloro-N-(3-iodophenyl)acetamide)
• 6286-37-9(N-(3,5-diiodophenyl)acetamide)
• 19591-17-4(N-(2-Iodophenyl)acetamide)
• 2033-43-4(Acetamide, N-(1-iodo-2-naphthalenyl)-)