Cas no 620601-77-6 ((R)-1-Cbz-2-Cyanopyrrolidine)
(R)-1-Cbz-2-Cyanopyrrolidine Chemical and Physical Properties
Names and Identifiers
-
- (R)-1-Cbz-2-Cyanopyrrolidine
- (R)-1-Cbz-2-cyano-pyrrolidine
- 1-Pyrrolidinecarboxylicacid, 2-cyano-, phenylmethyl ester, (2R)-
- benzyl (2R)-2-cyanopyrrolidine-1-carboxylate
- AS-38676
- SCHEMBL1437419
- (r)-benzyl 2-cyanopyrrolidine-1-carboxylate
- MFCD06796619
- DTXSID40466186
- Benzyl (R)-2-cyanopyrrolidine-1-carboxylate
- DB-031813
- 620601-77-6
- AUVGQGIWVNDVSL-GFCCVEGCSA-N
- (r)-2-cyano-pyrrolidine-1-carboxylic acid benzyl ester
- (r)-1-n-cbz-2-cyano-pyrrolidine
- Q-102180
- AKOS015836813
- CS-0146417
-
- MDL： MFCD06796619
- Inchi： 1S/C13H14N2O2/c14-9-12-7-4-8-15(12)13(16)17-10-11-5-2-1-3-6-11/h1-3,5-6,12H,4,7-8,10H2/t12-/m1/s1
- InChI Key： AUVGQGIWVNDVSL-GFCCVEGCSA-N
- SMILES： O(CC1C=CC=CC=1)C(N1CCC[C@@H]1C#N)=O
Computed Properties
- Exact Mass: 230.10600
- Monoisotopic Mass: 230.105527694g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 17
- Rotatable Bond Count: 4
- Complexity: 315
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 1
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 1.9
- Topological Polar Surface Area: 53.3?2
Experimental Properties
- Color/Form: Sticky Oil to Solid
- PSA: 53.33000
- LogP: 2.24908
(R)-1-Cbz-2-Cyanopyrrolidine Security Information
- Signal Word：Warning
- Hazard Statement： H302
- Warning Statement： P280;P305+P351+P338
- Storage Condition：Room temperature
(R)-1-Cbz-2-Cyanopyrrolidine Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
(R)-1-Cbz-2-Cyanopyrrolidine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM197888-5g |
(R)-1-Cbz-2-cyano-pyrrolidine |
620601-77-6 | 95+% | 5g |
$330 | 2021-08-05 | |
| Fluorochem | 034506-10g |
R)-1-Cbz-2-Cyano-pyrrolidine |
620601-77-6 | 97% | 10g |
￡660.00 | 2022-03-01 | |
| AstaTech | 67850-1/G |
(R)-1-CBZ-2-CYANO-PYRROLIDINE |
620601-77-6 | 97% | 1g |
$63 | 2023-09-16 | |
| AstaTech | 67850-5/G |
(R)-1-CBZ-2-CYANO-PYRROLIDINE |
620601-77-6 | 97% | 5g |
$229 | 2023-09-16 | |
| AstaTech | 67850-10/G |
(R)-1-CBZ-2-CYANO-PYRROLIDINE |
620601-77-6 | 97% | 10/G |
$990 | 2022-06-01 | |
| Fluorochem | 034506-1g |
R)-1-Cbz-2-Cyano-pyrrolidine |
620601-77-6 | 97% | 1g |
￡147.00 | 2022-03-01 | |
| Chemenu | CM197888-5g |
(R)-1-Cbz-2-cyano-pyrrolidine |
620601-77-6 | 95%+ | 5g |
$*** | 2023-05-30 | |
| TRC | C227888-50mg |
(R)-1-Cbz-2-cyanopyrrolidine |
620601-77-6 | 50mg |
$ 50.00 | 2022-04-01 | ||
| TRC | C227888-100mg |
(R)-1-Cbz-2-cyanopyrrolidine |
620601-77-6 | 100mg |
$ 65.00 | 2022-04-01 | ||
| TRC | C227888-500mg |
(R)-1-Cbz-2-cyanopyrrolidine |
620601-77-6 | 500mg |
$ 185.00 | 2022-04-01 |
(R)-1-Cbz-2-Cyanopyrrolidine Suppliers
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(R)-1-Cbz-2-Cyanopyrrolidine Related Literature
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Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
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Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
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Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
-
Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
Additional information on (R)-1-Cbz-2-Cyanopyrrolidine
Comprehensive Overview of (R)-1-Cbz-2-Cyanopyrrolidine (CAS No. 620601-77-6): Properties, Applications, and Industry Insights
(R)-1-Cbz-2-Cyanopyrrolidine (CAS No. 620601-77-6) is a high-value chiral building block widely utilized in pharmaceutical synthesis and asymmetric catalysis. This compound, featuring a pyrrolidine backbone with Cbz (carbobenzyloxy) and cyano functional groups, has garnered significant attention due to its versatility in constructing complex molecular architectures. Researchers and manufacturers frequently search for terms like "(R)-1-Cbz-2-Cyanopyrrolidine synthesis", "CAS 620601-77-6 supplier", and "chiral pyrrolidine derivatives", reflecting its growing demand in fine chemical markets.
The structural uniqueness of (R)-1-Cbz-2-Cyanopyrrolidine lies in its stereocenter at the 2-position, which enables enantioselective transformations critical for producing optically active compounds. Recent trends in green chemistry have spurred interest in optimizing its synthesis routes, with queries such as "sustainable production of cyanopyrrolidines" and "catalytic asymmetric cyanation methods" gaining traction. The compound's Cbz-protected amine moiety also makes it invaluable in peptide mimetics development, aligning with current drug discovery focuses on GPCR-targeted therapies and protease inhibitors.
Analytical characterization of CAS 620601-77-6 typically involves advanced techniques like HPLC chiral separation, NMR spectroscopy, and mass spectrometry. Industry professionals often inquire about "purity standards for (R)-1-Cbz-2-Cyanopyrrolidine" and "storage stability of cyanopyrrolidines", highlighting quality control considerations. The compound's stability under inert atmospheres and compatibility with common organic solvents (e.g., THF, DCM) makes it suitable for diverse reaction conditions.
Emerging applications of (R)-1-Cbz-2-Cyanopyrrolidine in bioconjugation chemistry and covalent inhibitor design have expanded its relevance. Search analytics reveal rising interest in "click chemistry modifications of cyanopyrrolidines" and "structure-activity relationship studies". Its role as a precursor to pyrrolidine-based organocatalysts also connects with the pharmaceutical industry's shift toward metal-free asymmetric synthesis methodologies.
From a regulatory perspective, CAS 620601-77-6 complies with major pharmacopeia standards when manufactured under GMP conditions. Frequent searches for "regulatory documentation for chiral intermediates" underscore the importance of proper certification in supply chains. The compound's low hygroscopicity and crystalline form at room temperature facilitate handling and transportation, addressing common logistical concerns in specialty chemical distribution.
Innovative research continues to explore derivatives of (R)-1-Cbz-2-Cyanopyrrolidine, particularly in structure-based drug design and peptidomimetic scaffolds. The scientific community actively investigates topics like "pyrrolidine ring conformational analysis" and "cyano group reactivity tuning", demonstrating the compound's ongoing relevance in cutting-edge chemistry. With the global chiral chemicals market projected to grow at 6.8% CAGR, 620601-77-6 remains a strategically important intermediate for academic and industrial applications alike.
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