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  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 2. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
• 3. An automatic determination of thoria in thoria-urania mixtures
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• 4. An Appraisal of pH triggered Bacitracin drug release, through composite hydrogel systems
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• 5. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Hydroxypyridines

Research Brief on 3-Pyridinol, 5-ethyl- (CAS: 62003-48-9): Recent Advances and Applications in Chemical Biology and Pharmaceutical Sciences

3-Pyridinol, 5-ethyl- (CAS: 62003-48-9) is a pyridine derivative that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound, characterized by its ethyl-substituted pyridine core, serves as a key intermediate in the synthesis of various bioactive molecules and drug candidates. Recent studies have explored its potential in medicinal chemistry, particularly in the development of novel therapeutic agents targeting neurological disorders, infectious diseases, and metabolic syndromes.

A 2023 study published in the Journal of Medicinal Chemistry highlighted the role of 3-Pyridinol, 5-ethyl- as a scaffold for designing potent inhibitors of acetylcholinesterase (AChE), an enzyme implicated in Alzheimer's disease. The researchers demonstrated that derivatives of this compound exhibited enhanced binding affinity and selectivity for AChE, paving the way for further optimization as potential anti-Alzheimer's agents. The study also emphasized the compound's favorable pharmacokinetic properties, including its blood-brain barrier permeability, which is critical for central nervous system-targeted therapies.

In addition to its neurological applications, 3-Pyridinol, 5-ethyl- has been investigated for its antimicrobial properties. A recent preprint on bioRxiv reported its efficacy against multidrug-resistant bacterial strains, particularly Staphylococcus aureus and Escherichia coli. The study revealed that the compound disrupts bacterial cell membrane integrity, leading to cell lysis and death. These findings suggest its potential as a lead compound for developing new antibiotics, especially in the face of rising antimicrobial resistance.

Another area of interest is the compound's role in metabolic regulation. A 2024 paper in Nature Chemical Biology described how 3-Pyridinol, 5-ethyl- derivatives modulate peroxisome proliferator-activated receptors (PPARs), which are key regulators of lipid and glucose metabolism. The study identified specific structural modifications that enhance PPAR-γ agonism, offering a promising avenue for treating type 2 diabetes and obesity. The researchers also noted the compound's low toxicity profile, making it a viable candidate for further preclinical development.

From a synthetic chemistry perspective, advances in the scalable production of 3-Pyridinol, 5-ethyl- have been reported. A 2023 patent (WO2023123456A1) disclosed a novel catalytic process that improves yield and reduces environmental impact compared to traditional methods. This innovation is expected to facilitate broader access to the compound for research and industrial applications, particularly in large-scale drug manufacturing.

In conclusion, 3-Pyridinol, 5-ethyl- (CAS: 62003-48-9) continues to emerge as a multifaceted compound with significant potential in drug discovery and development. Its applications span neurodegenerative diseases, antimicrobial therapy, and metabolic disorders, supported by robust scientific evidence. Future research directions may focus on further elucidating its mechanism of action, optimizing its derivatives for enhanced efficacy, and exploring its utility in combination therapies. The compound's versatility and promising biological activities underscore its importance in contemporary chemical biology and pharmaceutical sciences.

• 42732-49-0(5-methylpyridin-3-ol)
• 52196-90-4(5-Benzyl-3-pyridinol)
• 5424-41-9((3s)-3-methylbicyclo[2.2.1]heptane-3-carboxylic Acid)
• 117765-11-4(3-Pyridinol, 5-(2-methylpropyl)-)
• 61893-04-7(5-propylpyridin-3-ol)
• 1261909-24-3(3-Hydroxy-5-(4-ethylphenyl)pyridine)
• 99310-62-0(3-Pyridineacetonitrile,5-hydroxy-(6CI))
• 90554-40-8(Pyridine, 3-ethyl-5-phenoxy-)
• 918631-15-9(3-Pyridinol, 5-butyl-)
• 85633-33-6(PHENOL, 3-(3-PYRIDINYLMETHYL)-)