• 1. Development of a gas chromatography-mass spectrometry method for the determination of ultraviolet filters in beach sand samples
  Isuha Tarazona,Alberto Chisvert,Amparo Salvador Anal. Methods 2014 6 7772
• 2. Determination of seven commonly used organic UV filters in fresh and saline waters by liquid chromatography-tandem mass spectrometry
  Stephanie Bratkovics,Yelena Sapozhnikova Anal. Methods 2011 3 2943
• 3. Interfacial modification by multifunctional octocrylene for high efficiency and stable planar perovskite solar cells
  Yinyi Huang,Shina Li,Chaorong Wu,Shuo Wang,Chengyan Wang,RuiXin Ma Chem. Commun. 2020 56 6731
• 4. Synthesis and characterisation of novel composite sunscreens containing both avobenzone and octocrylene motifs
  Adam M. Cowden,Abigail L. Whittock,Emily L. Holt,Vasilios G. Stavros,Martin Wills RSC Adv. 2023 13 17017
• 5. An amended in vitro–in vivo extrapolation model that accounts for first pass clearance effects on chemical bioaccumulation in fish
  Leslie J. Saunders,John W. Nichols,Jon A. Arnot,James M. Armitage,Frank Wania Environ. Sci.: Processes Impacts 2023 25 741

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Diphenylmethanes
• Material Chemicals High Polymer Materials

Professional Introduction to Octocrylene (CAS No: 6197-30-4)

Octocrylene, with the chemical name 2,5,5-trimethyl-3-hexyl-2-cyclohexen-1-one, is a widely recognized and utilized compound in the field of chemical and pharmaceutical applications. Its unique molecular structure and properties make it an invaluable component in various formulations, particularly in sunscreens and personal care products. This introduction delves into the compound's characteristics, its applications, and the latest research findings that underscore its significance.

The molecular formula of Octocrylene is C₁₄H₂₀O, reflecting its non-polar nature and hydrophobic characteristics. These attributes contribute to its excellent solubility in oils and organic solvents, making it highly effective in cosmetic formulations. The compound's stability under UV light and its ability to absorb a broad spectrum of solar radiation have positioned it as a cornerstone ingredient in photoprotection products.

In recent years, the demand for high-efficacy sunscreens has surged, driven by increasing awareness of skin cancer risks and the desire for effective skin protection. Octocrylene has emerged as a preferred choice due to its ability to provide broad-spectrum UV protection while maintaining a lightweight texture in formulations. Its efficacy in absorbing UVA and UVB rays has been well-documented, making it a critical component in advanced sunscreen technologies.

The synthesis of Octocrylene involves a series of organic reactions that highlight the compound's complex molecular architecture. The process typically begins with the reaction of cyclohexanone with hexyl isobutyrate, followed by cyclization and hydrogenation steps. These synthetic pathways ensure high purity and yield, which are essential for pharmaceutical-grade applications. The latest advancements in catalytic processes have further refined the production of Octocrylene, enhancing its availability and cost-effectiveness.

Beyond its primary role in sunscreens, Octocrylene has found applications in other areas such as polymer additives and specialty coatings. Its thermal stability and resistance to oxidation make it an ideal candidate for enhancing the durability of various materials. Research is ongoing to explore new functionalities of this versatile compound, potentially expanding its utility in industrial applications.

The safety profile of Octocrylene has been extensively studied, with numerous clinical trials confirming its compatibility with human skin. Its low sensitization potential and minimal irritation make it suitable for use in sensitive skin formulations. Additionally, studies have shown that when used in appropriate concentrations within sunscreen products, Octocrylene does not pose significant health risks, further solidifying its reputation as a safe and effective ingredient.

In academic research, the photostability of Octocrylene has been a focal point due to its critical role in maintaining the integrity of sunscreen formulations over time. Recent studies have demonstrated that when incorporated into emulsion-based sunscreens, Octocrylene exhibits superior stability compared to other UV filters. This stability ensures consistent protection against solar radiation without degradation during storage or use.

The environmental impact of Octocrylene-based products has also been a subject of interest. While biodegradability studies suggest that the compound breaks down relatively quickly in aquatic environments, concerns about its persistence have led to research into more sustainable alternatives. Efforts are underway to develop bio-based derivatives of Octocrylene, which could offer similar protective properties while reducing environmental footprint.

The regulatory landscape governing the use of varies by region but generally aligns with stringent safety standards set by agencies such as the FDA and ECHA. Compliance with these regulations ensures that products containing this compound meet rigorous quality and performance criteria. Manufacturers must adhere to Good Manufacturing Practices (GMP) and undergo rigorous testing to validate the safety and efficacy of their formulations.

In conclusion, stands as a testament to innovation in chemical formulation. Its multifaceted applications, coupled with ongoing research into its properties and potential uses, underscore its importance in both consumer products and industrial solutions. As scientific understanding advances, the role of this remarkable compound is expected to expand even further, driving new developments across multiple sectors.

• 119-61-9(Benzophenone)
• 104-76-7(2-Ethyl-1-hexanol)
• 18300-89-5((E)-2-Cyano-3-phenyl-but-2-enoic Acid Ethyl Ester)
• 178671-58-4(Uvinul 3030)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)