• 1. 497. Studies in pyrolysis. Part X. Model systems for the pyrolysis of poly(ethylene terephthalate) : 2-hydroxyethyl benzoate and related substances
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers
• Other Chemical Reagents

Comprehensive Overview of 2-Phenoxyethyl Acetate (CAS No. 6192-44-5): Properties, Applications, and Industry Trends

2-Phenoxyethyl acetate (CAS No. 6192-44-5), also known as phenoxyethyl acetate or ethylene glycol monophenyl ether acetate, is a versatile organic compound widely utilized in the fragrance, flavor, and specialty chemical industries. This ester derivative combines the aromatic characteristics of phenoxyethanol with the ester functionality of acetic acid, resulting in a unique profile that appeals to formulators seeking balanced solubility and olfactory properties.

The molecular structure of 2-Phenoxyethyl acetate features a phenyl group linked via an ether bond to an ethyl chain terminated with an acetate moiety. This configuration grants it a mild, sweet floral aroma with fruity undertones, making it a popular choice for perfume formulations, cosmetic additives, and flavor enhancers. Recent trends in clean beauty products and sustainable fragrance development have renewed interest in this compound as a potential alternative to synthetic musks or phthalate-based carriers.

From a physicochemical perspective, CAS 6192-44-5 typically presents as a colorless to pale yellow liquid with a boiling point ranging between 245-250°C and a density of approximately 1.10 g/cm3 at 20°C. Its moderate volatility and solubility in organic solvents (while being sparingly soluble in water) make it particularly valuable for cosmetic emulsions and polymer plasticizers. Industry research indicates growing applications in nail polish formulations where it functions as both a solvent and film-forming aid.

The synthesis of 2-Phenoxyethyl acetate commonly involves the esterification of 2-phenoxyethanol with acetic anhydride or acetyl chloride in the presence of acid catalysts. Advanced production methods now emphasize green chemistry principles, including enzymatic catalysis and solvent-free systems, responding to market demands for eco-friendly chemical processes. Analytical techniques such as GC-MS analysis and FTIR spectroscopy are routinely employed for quality control to ensure compliance with IFRA standards for fragrance ingredients.

In the context of modern cosmetic science, this compound has gained attention for its compatibility with vegan formulations and cruelty-free products. Formulators appreciate its ability to enhance the longevity of floral notes while maintaining stability in pH-sensitive systems. Recent patents highlight innovative uses in microencapsulation technologies for controlled fragrance release, particularly in fabric care products and home fragrance diffusers.

Regulatory status of 2-Phenoxyethyl acetate varies by region, with generally favorable assessments from ECHA and FDA for specific applications. The OECD SIDS program has reviewed its environmental fate, noting ready biodegradability under standard test conditions. However, manufacturers must stay informed about evolving REACH compliance requirements and restricted substances lists in consumer products.

Emerging research explores the compound's potential in bio-based plasticizers for biodegradable polymers, aligning with circular economy initiatives. Its low toxicity profile compared to traditional phthalates makes it a candidate for medical device coatings and food contact materials. The personal care industry continues to investigate its synergies with natural essential oils and botanical extracts in aromatherapy products.

Market analysts project steady growth for phenoxyethanol derivatives like 2-Phenoxyethyl acetate, driven by expanding premium fragrance markets in Asia-Pacific regions and innovation in functional fragrances for technical textiles. Sustainable sourcing of raw materials and carbon footprint reduction in production processes represent key challenges and opportunities for industry stakeholders moving forward.

Quality specifications for CAS 6192-44-5 typically require ≥98% purity, with strict limits on residual solvents and heavy metals. Leading manufacturers now provide GC chromatograms and NMR spectra as standard documentation, while advanced HPLC methods enable detection of isomeric impurities. Storage recommendations emphasize protection from moisture and oxidation in HDPE containers under inert atmosphere for extended shelf life.

From a technical standpoint, the compound's Hansen solubility parameters (δD ≈ 18.5, δP ≈ 5.5, δH ≈ 8.5 MPa^1/2) facilitate its use as a coalescing agent in water-based coatings and ink formulations. Recent studies demonstrate improved film formation in latex paints when incorporated at 2-5% w/w, without compromising VOC compliance in architectural applications.

Innovative applications continue to emerge, including its use as a reaction medium for organocatalyzed transformations and as a phase-transfer agent in biphasic systems. The compound's balanced lipophilic-hydrophilic character makes it valuable for extraction processes in natural product isolation, particularly for polyphenol recovery from plant matrices.

As consumer awareness grows regarding transparent ingredient labeling, manufacturers are increasingly documenting the life cycle assessment of 2-Phenoxyethyl acetate production. The development of bio-based routes from lignin-derived phenols represents an active area of research, potentially positioning this compound as a renewable platform chemical in future green manufacturing paradigms.

• 23495-12-7(Ethanol, 2-phenoxy-,1-propanoate)
• 1984-60-7(Acetic acid,2-phenoxy-, 2-hydroxyethyl ester)
• 60359-67-3(Acetic acid, hydroxy-, 2-phenoxyethyl ester)
• 60359-62-8(Acetic acid, methoxy-, 2-phenoxyethyl ester)
• 2555-49-9(Ethyl phenoxyacetate)
• 14316-61-1(Phenoxyacetic anhydride)
• 18598-23-7(Acetic acid,2-(4-methoxyphenoxy)-, ethyl ester)
• 82815-86-9(ethyl 2-(3-methoxyphenoxy)acetate)
• 68747-24-0(Acetic acid, (3-hydroxyphenoxy)-, ethyl ester)
• 60359-58-2(Acetic acid, (acetyloxy)-, 2-phenoxyethyl ester)