• 1. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 2. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 4. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzothiazoles Benzothiazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzothiazoles

Introduction to 6-Chlorobenzodthiazol-2-amine Hydrochloride (CAS No. 61827-71-2)

6-Chlorobenzodthiazol-2-amine hydrochloride (CAS No. 61827-71-2) is a compound of significant interest in the fields of medicinal chemistry and pharmaceutical research. This compound, also known as 6-chloro-1,3-benzothiazol-2-amine hydrochloride, is a derivative of benzothiazole, a heterocyclic aromatic compound with a wide range of applications in the development of novel drugs and therapeutic agents.

The structure of 6-Chlorobenzodthiazol-2-amine hydrochloride consists of a benzothiazole ring with a chlorine substituent at the 6-position and an amino group at the 2-position, forming a salt with hydrochloric acid. This unique structural arrangement confers specific chemical and biological properties that make it a valuable candidate for various pharmacological studies.

In recent years, there has been growing interest in the use of benzothiazole derivatives in the development of new drugs, particularly for their potential as antiviral, antibacterial, and anticancer agents. The presence of the chlorine substituent and the amino group in 6-Chlorobenzodthiazol-2-amine hydrochloride enhances its ability to interact with biological targets, making it a promising lead compound for further optimization.

One of the key areas of research involving 6-Chlorobenzodthiazol-2-amine hydrochloride is its potential as an antiviral agent. Studies have shown that this compound exhibits inhibitory activity against various viral strains, including influenza and herpes simplex virus (HSV). The mechanism of action is believed to involve interference with viral replication processes, thereby reducing viral load and preventing the spread of infection.

Beyond antiviral applications, 6-Chlorobenzodthiazol-2-amine hydrochloride has also been investigated for its antibacterial properties. Research has demonstrated that this compound possesses broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria. The ability to inhibit bacterial growth makes it a potential candidate for the development of new antibiotics to combat multidrug-resistant strains.

In the realm of cancer research, 6-Chlorobenzodthiazol-2-amine hydrochloride has shown promise as an anticancer agent. Preclinical studies have indicated that this compound can induce apoptosis in cancer cells while sparing normal cells. The selective cytotoxicity observed in these studies suggests that 6-Chlorobenzodthiazol-2-amine hydrochloride may have therapeutic potential in cancer treatment.

The pharmacokinetic properties of 6-Chlorobenzodthiazol-2-amine hydrochloride have also been studied to evaluate its suitability as a drug candidate. Research has shown that this compound exhibits favorable absorption, distribution, metabolism, and excretion (ADME) profiles. Its good oral bioavailability and low toxicity make it an attractive option for further development into a viable therapeutic agent.

To further enhance the therapeutic potential of 6-Chlorobenzodthiazol-2-amine hydrochloride, ongoing efforts are focused on structure-activity relationship (SAR) studies. These studies aim to identify key structural modifications that can improve the potency and selectivity of the compound while minimizing adverse effects. By optimizing these properties, researchers hope to develop more effective drugs based on this benzothiazole derivative.

In conclusion, 6-Chlorobenzodthiazol-2-amine hydrochloride (CAS No. 61827-71-2) is a versatile compound with significant potential in various areas of medicinal chemistry and pharmaceutical research. Its unique chemical structure and biological properties make it a valuable lead compound for the development of new drugs targeting viral infections, bacterial infections, and cancer. Ongoing research continues to uncover new applications and optimize its therapeutic potential, positioning it as an important molecule in the future landscape of drug discovery.

• 25150-27-0(6,7-dichloro-1,3-benzothiazol-2-amine)
• 24072-75-1(2-Amino-5,6-dichlorobenzothiazole)
• 27058-83-9(2-Amino-4-chlorobenzothiazole hydrobromide)
• 1849-70-3(4,7-dichloro-1,3-benzothiazol-2-amine)
• 16582-59-5(4,6-dichloro-1,3-benzothiazol-2-amine)
• 20358-00-3(2-Amino-5-chlorobenzothiazole)
• 95-24-9(6-chloro-1,3-benzothiazol-2-amine)
• 136-95-8(Benzo[d]thiazol-2-amine)
• 19952-47-7(4-chloro-1,3-benzothiazol-2-amine)
• 158465-13-5(5,7-DichlorobenzoDthiazol-2-amine)