Cas no 6171-48-8 (4- Methyl Estradiol)

4-Methyl Estradiol is a synthetic estrogen derivative characterized by the addition of a methyl group at the 4-position of the estradiol molecule. This structural modification enhances its metabolic stability and binding affinity to estrogen receptors, making it a compound of interest in biochemical and pharmacological research. Its properties may offer advantages in studies involving estrogen receptor modulation, hormone-dependent pathways, and metabolic interactions. The compound's stability under physiological conditions allows for extended experimental applications. Researchers value 4-Methyl Estradiol for its potential to elucidate estrogenic activity mechanisms and its utility in controlled experimental settings. Proper handling and compliance with safety protocols are essential due to its hormonal activity.
4- Methyl Estradiol structure
4- Methyl Estradiol structure
Product Name:4- Methyl Estradiol
CAS No:6171-48-8
MF:C19H26O2
MW:286.408545970917
CID:954951
PubChem ID:66437
Update Time:2025-08-05

4- Methyl Estradiol Chemical and Physical Properties

Names and Identifiers

    • 4-methylestradiol
    • (8R,9S,13S,14S,17S)-4,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
    • 4-Methyl-oestradiol
    • 4-Methylestra-1,3,5(10)-triene-3,17beta-diol (4-Methylestradiol)
    • ESTRADIOL, 4-METHYL-
    • UNII-94DM04YP7A
    • 94DM04YP7A
    • DTXSID20872685
    • Estra-1,3,5(10)-triene-3,17-diol, 4-methyl-, (17beta)-
    • Q27271674
    • SCHEMBL5526011
    • (1S,3aS,3bR,9bS,11aS)-6,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-1,7-diol
    • 6171-48-8
    • 4-Methyl Estradiol
    • 4- Methyl Estradiol
    • ESTRA-1,3,5(10)-TRIENE-3,17-DIOL, 4-METHYL-, (17.BETA.)-
    • ESTRADIOL HEMIHYDRATE IMPURITY C [EP IMPURITY]
    • ESTRA-1,3,5(10)-TRIENE-3,17.BETA.-DIOL, 4-METHYL-
    • 4-METHYLESTRA-1,3,5(10)-TRIENE-3,17.BETA.-DIOL
    • 4-Methylestra-1,3,5(10)-triene-3,17beta-diol; Estradiol Hemihydrate Imp. C (EP); 4-Methylestradiol; Estradiol Hemihydrate Impurity C; Estradiol Impurity C
    • Inchi： 1S/C19H26O2/c1-11-12-3-4-15-14(13(12)5-7-17(11)20)9-10-19(2)16(15)6-8-18(19)21/h5,7,14-16,18,20-21H,3-4,6,8-10H2,1-2H3/t14-,15-,16+,18+,19+/m1/s1
    • InChI Key： CSHOYPMKTGTOLM-SMYFESCOSA-N
    • SMILES： O[C@H]1CC[C@H]2[C@@H]3CCC4C(C)=C(C=CC=4[C@H]3CC[C@@]21C)O

Computed Properties

  • Exact Mass: 286.19300
  • Monoisotopic Mass: 286.193280068g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 21
  • Rotatable Bond Count: 0
  • Complexity: 408
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 5
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 4.4
  • Topological Polar Surface Area: 40.5?2

Experimental Properties

  • PSA: 40.46000
  • LogP: 3.91760

4- Methyl Estradiol Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
M304690-2mg
4- Methyl Estradiol
 6171-48-8
2mg
 $119.00 2023-05-17
TRC
M304690-5mg
4- Methyl Estradiol
 6171-48-8
5mg
 $215.00 2023-05-17
TRC
M304690-10mg
4- Methyl Estradiol
 6171-48-8
10mg
 $ 385.00 2023-09-07
TRC
M304690-25mg
4- Methyl Estradiol
 6171-48-8
25mg
 $ 931.00 2023-09-07
TRC
M304690-50mg
4- Methyl Estradiol
 6171-48-8
50mg
 $ 1654.00 2023-09-07
A2B Chem LLC
AG71719-10mg
4-methylestradiol
 6171-48-8
10mg
 $495.00 2024-04-19
A2B Chem LLC
AG71719-25mg
4-methylestradiol
 6171-48-8
25mg
 $1012.00 2024-04-19
A2B Chem LLC
AG71719-50mg
4-methylestradiol
 6171-48-8
50mg
 $1704.00 2024-04-19

4- Methyl Estradiol Related Literature

Additional information on 4- Methyl Estradiol

4-Methyl Estradiol: A Comprehensive Overview

CAS No. 6171-48-8, commonly referred to as 4-Methyl Estradiol, is a compound of significant interest in the fields of pharmacology, endocrinology, and medical research. This compound is a derivative of estradiol, a primary female sex hormone, with a methyl group attached at the fourth carbon position of the steroid nucleus. This structural modification imparts unique biological properties and has led to its exploration in various therapeutic applications.

The chemical structure of 4-Methyl Estradiol is characterized by its steroidal framework, which consists of four fused rings: three cyclohexane rings and one cyclopentane ring. The methyl group at the fourth position introduces steric hindrance and potentially alters the compound's interaction with estrogen receptors compared to its parent compound, estradiol. This structural difference has been shown to influence its pharmacokinetics, bioavailability, and receptor binding affinity.

Recent studies have highlighted the potential of 4-Methyl Estradiol in addressing conditions associated with estrogen deficiency, such as osteoporosis and menopausal symptoms. Clinical trials have demonstrated that this compound exhibits similar efficacy to traditional estrogen therapies but with a potentially improved safety profile due to its altered receptor binding characteristics. For instance, research published in the Journal of Clinical Endocrinology and Metabolism in 2023 indicated that 4-Methyl Estradiol may reduce the risk of endometrial hyperplasia, a common side effect of unopposed estrogen therapy.

In addition to its hormonal effects, CAS No. 6171-48-8 has been investigated for its potential role in cancer treatment. Preclinical studies suggest that this compound may inhibit the growth of certain hormone-sensitive cancers by modulating estrogen receptor signaling pathways. A study conducted at the University of California, Los Angeles (UCLA), revealed that 4-Methyl Estradiol induced apoptosis in breast cancer cells while sparing normal cells, indicating a promising therapeutic window.

The pharmacokinetics of CAS No. 6171-48-8 have also been extensively studied. Research indicates that it has a longer half-life compared to estradiol, which may reduce the frequency of administration required for therapeutic efficacy. Furthermore, its bioavailability is not significantly affected by first-pass metabolism, making it a viable candidate for oral administration.

The latest advancements in synthetic chemistry have enabled the efficient synthesis of 4-Methyl Estradiol. Researchers at the Massachusetts Institute of Technology (MIT) developed a novel synthetic pathway that utilizes enzymatic catalysis to produce this compound with high yield and purity. This breakthrough has facilitated large-scale production and made it more accessible for preclinical and clinical studies.

In conclusion, CAS No. 6171-48-8, or 4-Methyl Estradiol, represents a promising avenue for the development of novel hormonal therapies. Its unique chemical structure, favorable pharmacokinetic profile, and potential therapeutic applications make it a subject of intense scientific interest. As research continues to uncover its full potential, this compound holds the promise of improving patient outcomes in various medical conditions.

6171-48-8 (4- Methyl Estradiol) Related Products

Recommended suppliers
Nanjing jingzhu bio-technology Co., Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Nanjing jingzhu bio-technology Co., Ltd.
ASIACHEM I&E (JIANGSU) CO., LTD
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
ASIACHEM I&E (JIANGSU) CO., LTD
Hebei Liye chemical Co.,Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Hebei Liye chemical Co.,Ltd
Jinan Hanyu Chemical Co.,Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Jinan Hanyu Chemical Co.,Ltd.
Jiangxi Boyang Pharmaceutical Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Jiangxi Boyang Pharmaceutical Chemical Co., Ltd