• 1. An amorphous lanthanum–iridium solid solution with an open structure for efficient water splitting?
  Wei Sun,Chenglong Ma,Xinlong Tian,Jianjun Liao,Ji Yang,Chengjun Ge,Weiwei Huang J. Mater. Chem. A, 2020,8, 12518-12525
• 2. An artificial photosynthetic system for photoaccumulation of two electrons on a fused dipyridophenazine (dppz)–pyridoquinolinone ligand?
  Philipp Traber,Stephan Kupfer,Stefanie Gr?fe,Isabelle Baussanne,Martine Demeunynck,Jean-Marie Mouesca,Serge Gambarelli,Vincent Artero,Murielle Chavarot-Kerlidou Chem. Sci., 2018,9, 4152-4159
• 3. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
• 4. Alumina coating on 5 V lithium cobalt fluorophosphate cathode material for lithium secondary batteries – synthesis and electrochemical properties?
  S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115
• 5. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584

Introduction to 3-(2-Bromophenyl)propanenitrile (CAS No. 61698-07-5)

3-(2-Bromophenyl)propanenitrile, also known by its CAS number 61698-07-5, is a versatile organic compound with significant applications in the fields of chemical synthesis, pharmaceutical research, and materials science. This compound is characterized by its unique molecular structure, which consists of a bromophenyl group attached to a propionitrile moiety. The combination of these functional groups imparts specific chemical and physical properties that make it an essential building block in various synthetic pathways.

The molecular formula of 3-(2-bromophenyl)propanenitrile is C₉H₈BrN, and its molecular weight is approximately 206.07 g/mol. The compound is a colorless to pale yellow liquid at room temperature and has a boiling point of around 190-195°C at atmospheric pressure. It is slightly soluble in water but highly soluble in organic solvents such as ethanol, acetone, and dichloromethane. These solubility properties make it suitable for use in a wide range of chemical reactions and processes.

In the realm of chemical synthesis, 3-(2-bromophenyl)propanenitrile serves as a valuable intermediate for the preparation of more complex molecules. Its bromine atom can be readily substituted or eliminated in various reactions, making it an excellent starting material for the synthesis of substituted phenylpropionitriles and related compounds. For instance, recent studies have explored the use of this compound in the development of novel catalysts and ligands for transition metal-catalyzed reactions. These catalysts have shown enhanced activity and selectivity in cross-coupling reactions, which are crucial for the synthesis of pharmaceuticals and fine chemicals.

In the pharmaceutical industry, 3-(2-bromophenyl)propanenitrile has gained attention due to its potential as a precursor for the synthesis of bioactive molecules. Research has shown that derivatives of this compound exhibit promising biological activities, including anti-inflammatory, antimicrobial, and anticancer properties. For example, a study published in the Journal of Medicinal Chemistry reported that certain derivatives of 3-(2-bromophenyl)propanenitrile demonstrated significant inhibition of cancer cell proliferation through the modulation of specific signaling pathways.

The versatility of 3-(2-bromophenyl)propanenitrile extends beyond its use as an intermediate in chemical synthesis. It has also found applications in materials science, particularly in the development of functional polymers and coatings. The presence of the nitrile group provides opportunities for further functionalization and cross-linking, leading to materials with improved mechanical properties and thermal stability. Recent advancements in polymer chemistry have utilized this compound to create novel materials with enhanced performance characteristics for use in electronics, automotive, and aerospace industries.

Safety considerations are paramount when handling 3-(2-bromophenyl)propanenitrile. While it is not classified as a hazardous substance under current regulations, proper precautions should be taken to ensure safe handling and storage. This includes using appropriate personal protective equipment (PPE), such as gloves and safety goggles, and working in well-ventilated areas to minimize exposure to vapors.

In conclusion, 3-(2-bromophenyl)propanenitrile (CAS No. 61698-07-5) is a multifaceted compound with a wide range of applications in chemical synthesis, pharmaceutical research, and materials science. Its unique molecular structure and versatile reactivity make it an invaluable tool for researchers and chemists working on innovative projects across various fields. As ongoing research continues to uncover new possibilities for its use, the importance of this compound is likely to grow even further.

• 70268-40-5(Benzeneacetonitrile, bromo-)
• 178809-32-0(4-(2-Bromophenyl)butanenitrile)
• 56403-44-2(1,4-Benzenediacetonitrile, 2,5-dibromo-)
• 57775-08-3(3-(4-Bromophenyl)propionitrile)
• 19472-74-3(2-(2-Bromophenyl)acetonitrile)
• 852697-76-8(1,3,5-BENZENETRIACETONITRILE, 2,4,6-TRIBROMO-)
• 254745-36-3(Benzonitrile, 4-bromo-3-propyl-)
• 74533-21-4(2-(2,5-Dibromophenyl)acetonitrile)
• 1069114-80-2(2-(2-bromo-4-methylphenyl)acetonitrile)
• 248920-09-4(2-(2-bromo-3-methylphenyl)acetonitrile)