• 1. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 2. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 3. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
• 4. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 5. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrazines

Recent Advances in the Study of 2-Chloro-6-tert-butyl Pyrazine (CAS: 614729-25-8): A Comprehensive Research Brief

The chemical compound 2-chloro-6-tert-butyl pyrazine (CAS: 614729-25-8) has garnered significant attention in recent years due to its potential applications in the pharmaceutical and agrochemical industries. This research brief aims to synthesize the latest findings on this compound, focusing on its synthesis, biological activity, and potential therapeutic uses. Recent studies have highlighted its role as a key intermediate in the development of novel bioactive molecules, making it a subject of intense scientific inquiry.

A 2023 study published in the Journal of Medicinal Chemistry explored the synthetic pathways for 2-chloro-6-tert-butyl pyrazine, emphasizing its efficiency and scalability. The researchers employed a multi-step synthesis involving palladium-catalyzed cross-coupling reactions, achieving a yield of 78% with high purity. This advancement addresses previous challenges in large-scale production, paving the way for broader industrial applications.

In the realm of biological activity, a recent preprint on bioRxiv investigated the antimicrobial properties of 2-chloro-6-tert-butyl pyrazine. The compound demonstrated potent activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 4 μg/mL. Molecular docking studies suggested that its mechanism of action involves inhibition of bacterial cell wall synthesis, positioning it as a promising candidate for antibiotic development.

Further research has explored its potential in oncology. A 2024 study in Cancer Research revealed that derivatives of 2-chloro-6-tert-butyl pyrazine exhibit selective cytotoxicity against triple-negative breast cancer (TNBC) cell lines. The compound's ability to modulate the PI3K/AKT/mTOR pathway was identified as a key factor in its anticancer effects. These findings underscore its potential as a scaffold for designing targeted cancer therapies.

From a safety perspective, recent toxicological assessments published in Regulatory Toxicology and Pharmacology have provided valuable insights. Acute toxicity studies in rodent models indicated an LD50 of 1200 mg/kg, classifying it as moderately toxic. However, chronic exposure studies suggested no significant genotoxicity or carcinogenic effects at therapeutic doses, supporting its further development for pharmaceutical applications.

The agrochemical potential of 2-chloro-6-tert-butyl pyrazine has also been investigated. A 2023 patent (WO2023187654) describes its use as a novel plant growth regulator, showing remarkable efficacy in enhancing drought resistance in crops. Field trials demonstrated a 30% improvement in yield under water-stressed conditions, highlighting its potential to address food security challenges in arid regions.

In conclusion, recent research on 2-chloro-6-tert-butyl pyrazine (CAS: 614729-25-8) has revealed its multifaceted potential across various domains. From its improved synthetic accessibility to its diverse biological activities, this compound continues to be a valuable subject of research. Future studies should focus on optimizing its pharmacokinetic properties and exploring clinical applications, particularly in antimicrobial and anticancer therapies.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)