Cas no 6138-23-4 (D-(+)-Trehalose dihydrate)

D-(+)-Trehalose dihydrate is a non-reducing disaccharide composed of two glucose units linked by an α,α-1,1-glycosidic bond. Known for its high stability and biocompatibility, it serves as an effective cryoprotectant and lyoprotectant in pharmaceutical and biotechnological applications. Its ability to preserve cellular integrity during freeze-drying and thermal stress makes it valuable in stabilizing proteins, vaccines, and other labile biomolecules. The dihydrate form enhances solubility and handling properties. Additionally, D-(+)-Trehalose dihydrate exhibits low reactivity, making it suitable for use in diagnostics, food science, and cosmetics. Its non-toxic and non-hygroscopic nature further supports its utility in sensitive formulations.
D-(+)-Trehalose dihydrate structure
D-(+)-Trehalose dihydrate structure
Product Name:D-(+)-Trehalose dihydrate
CAS No:6138-23-4
MF:C12H26O13
MW:378.327045917511
MDL:MFCD00071594
CID:46425
PubChem ID:24900427
Update Time:2025-09-23

D-(+)-Trehalose dihydrate Chemical and Physical Properties

Names and Identifiers

    • D(+)-Trehalose dihydrate
    • D-Trehalose, dihydrate ?,?-Trehalose, dihydrate
    • D(+)trehalose dihydrate cell*culture tested
    • D(+)trehalose dihydrate
    • D(+)trehalose reduced metal ion content dihydrate
    • D(+)Trehalose
    • alpha-D-Glucopyranosyl-alpha-D-glucopyranoside
    • D-(+)-Trehalose
    • D-(+)-Trehalose dihydrate
    • D(+)-Trehalose
    • D-(+)-Trehalose Dihy
    • D-Trehalose dihydrate
    • Trehalose
    • TREHALOSE DIHYDRATE, D-(+)-(RG) PrintBack
    • α,α-Trehalose
    • D(+)-Trehalose dihydrate (for injection)
    • Trehalose dihydrate
    • a,a-Trehalose
    • alpha,alpha-Trehalose dihydrate
    • 7YIN7J07X4
    • d-trehalose-dihyd
    • Mycose,1-O-alpha-D-glucopyranosyl-alpha-D-glucopyranoside
    • AK117470
    • dextro-trehalose dihydrate
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-3,4,5-triol
    • a,a-D-Trehalose dihydrate
    • D
    • α,α-Trehalose dihydrate
    • D-(+)-Trehalose dihydrate (D-Trehalose dihydrate; alpha,alpha-Trehalose dihydrate)
    • a,a-Trehalose dihydrate
    • 99-20-7 (anhydrous)
    • Trehalose, United States Pharmacopeia (USP) Reference Standard
    • D-(+)-Trehalose dihydrate, from Saccharomyces cerevisiae, >=99%
    • AKOS016010526
    • TREHALOSE DIHYDRATE [EP MONOGRAPH]
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol;dihydrate
    • Trehalose (for injection) (sterile)
    • 2,2'-(1,6-Hexanediyldioxy)bisbenzaldehyde
    • S3992
    • (2R,2'R,3S,3'S,4S,4'S,5R,5'R,6R,6'R)-6,6'-Oxybis(2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol) dihydrate
    • .ALPHA., .ALPHA.-TREHALOSE DIHYDRATE
    • Q27269028
    • D-(+)-Trehalose dihydrate, for microbiology, >=99.0%
    • D70602
    • D-Trehalose; ,-Trehalose
    • DPVHGFAJLZWDOC-PVXXTIHASA-N
    • DTXCID9027948
    • D-(+)-Trehalose dihydrate, from Saccharomyces cerevisiae, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, >=99%
    • D-(+)-Trehalose dihydrate, from Saccharomyces cerevisiae, BioReagent, plant cell culture tested
    • BP-20564
    • MFCD00071594
    • FEMA NO. 4600
    • TREHALOSE DIHYDRATE [MI]
    • AS-11785
    • TREHALOSE, DIHYDRATE
    • DTXSID3047972
    • MYCOSE DIHYDRATE
    • Trehalose dihydrate; ?-d-Glucopyranosyl ?-d-glucopyranoside dihydrate (?,?-trehalose dihydrate)
    • a-d-glucopyranosyl-a-d-glucopyranoside
    • D-Trehalose dihydrate 1000 microg/mL in Water
    • Trehalose dihydrate, cell culture
    • Trehalose dihydrate, European Pharmacopoeia (EP) Reference Standard
    • D-Trehalose dihydrate; ,-Trehalose dihydrate
    • Trehalose, Pharmaceutical Secondary Standard; Certified Reference Material
    • CCG-268385
    • SCHEMBL166078
    • Tox21_201106
    • D-(+)-Trehalose dihydrate, Vetec(TM) reagent grade, >=99%
    • .ALPHA.-D-GLUCOPYRANOSYL-.ALPHA.-D-GLUCOPYRANOSIDE DIHYDRATE
    • D-(+)-Trehalose dihydrate, from Saccharomyces cerevisiae, >=98.5% (HPLC)
    • a-D-Glucopyranosyl-a-D-glucopyranoside dihydrate
    • CHEMBL3188936
    • HMS3885G16
    • 2-(hydroxymethyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-3,4,5-triol dihydrate;D-(+)-Trehalose dihydrate
    • alpha-D-Glucopyranoside, alpha-D-glucopyranosyl, dihydrate
    • CAS-6138-23-4
    • D-(+)-Trehalose dihydrate, SAJ special grade, >=99.0%
    • NCGC00258658-01
    • A833195
    • TREHALOSE DIHYDRATE [WHO-DD]
    • (2R,2'R,3S,3'S,4S,4'S,5R,5'R,6R,6'R)-6,6'-Oxybis(2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol)dihydrate
    • UNII-7YIN7J07X4
    • D-(+)-Trehalose dihydrate, p.a., 99%
    • 6138-23-4
    • DA-72521
    • Trehalose dihydrate; a-d-Glucopyranosyl a-d-glucopyranoside dihydrate (a,a-trehalose dihydrate)
    • for cell culture,for insect cell culture, inverted exclamation markY99%
    • MDL: MFCD00071594
    • Inchi: 1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
    • InChI Key: DPVHGFAJLZWDOC-PVXXTIHASA-N
    • SMILES: O([C@@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O)[C@@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O.O.O
    • BRN: 5322018

Computed Properties

  • Exact Mass: 378.13700
  • Monoisotopic Mass: 378.137
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 10
  • Hydrogen Bond Acceptor Count: 13
  • Heavy Atom Count: 25
  • Rotatable Bond Count: 4
  • Complexity: 348
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 10
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 192
  • Surface Charge: 0
  • XLogP3: -4.2

Experimental Properties

  • Color/Form: White to off white crystalline powder
  • Density: 1.7600
  • Melting Point: 97-99 oC
  • Boiling Point: 675.4℃ at 760 mmHg
  • Flash Point: 362.3oC
  • Refractive Index: 181 ° (C=7, H2O)
  • Solubility: H2O: 50?mg/mL
  • Water Partition Coefficient: 68.9 g/100 mL (20 oC)
  • PSA: 207.99000
  • LogP: -5.52580
  • Merck: 9580
  • Sensitiveness: Hygroscopic
  • FEMA: 4600 | TREHALOSE, DIHYDRATE
  • Specific Rotation: 179 o (c=2, H2O)
  • Optical Activity: [α]20/D +179±3°, c =?2% in H2O
  • Solubility: Soluble in hot ethanol, insoluble in ether

D-(+)-Trehalose dihydrate Security Information

  • Signal Word:warning
  • Hazard Statement: H303
  • Warning Statement: P312
  • Hazardous Material transportation number:NONH for all modes of transport
  • WGK Germany:2
  • Hazard Category Code: R38
  • Safety Instruction: S37/39-S26
  • FLUKA BRAND F CODES:3-10
  • Regulatory Condition Code:Class Q (sugars, alkaloids, antibiotics, hormones)
  • RTECS:LZ5776547
  • Hazardous Material Identification: Xi
  • TSCA:Yes
  • Storage Condition:Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
  • Risk Phrases:R38
  • Safety Term:S26;S37/39

D-(+)-Trehalose dihydrate Customs Data

  • HS CODE:29400000
  • Customs Data:

    China Customs Code:

    2932999099

    Overview:

    2932999099. Other heterocyclic compounds containing only oxygen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

D-(+)-Trehalose dihydrate Pricemore >>

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D-(+)-Trehalose dihydrate Suppliers

Suzhou Senfeida Chemical Co., Ltd
Gold Member
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(CAS:6138-23-4)D(+)-Trehalose dihydrate
Order Number:sfd10205
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:35
Price ($):discuss personally
Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:6138-23-4)D(+)-Trehalose dihydrate
Order Number:LE6347;LE2470926;LE9735
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 11:49
Price ($):discuss personally
Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:6138-23-4)D-(+)-Trehalose dihydrate
Order Number:A833195
Stock Status:in Stock
Quantity:500g
Purity:99%
Pricing Information Last Updated:Monday, 2 September 2024 15:32
Price ($):312.0

D-(+)-Trehalose dihydrate Spectrogram

1H NMR 300 MHz DMSO
1H NMR
13C NMR
13C NMR
Recommended suppliers
Suzhou Senfeida Chemical Co., Ltd
(CAS:6138-23-4)D(+)-Trehalose dihydrate
sfd10205
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Email
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:6138-23-4)D(+)-Trehalose dihydrate
LE6347;LE2470926;LE9735
Purity:99%/99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry/Inquiry
Email