• 1. 1,6-Dimethyl-4-hydroxy-3-pyridinecarboxylic acid and 4-hydroxy-2-methyl-3-pyridinecarboxylic acid as new possible chelating agents for iron and aluminium
  Annalisa Dean,Maria Grazia Ferlin,Paola Brun,Ignazio Castagliuolo,Robert A. Yokel,Denis Badocco,Paolo Pastore,Alfonso Venzo,G. Giorgio Bombi,Valerio B. Di Marco Dalton Trans. 2009 1815
• 2. Hydroxynicotinic acid crystallisation and solubility systematic studies
  Catarina V. Esteves New J. Chem. 2022 46 21124
• 3. Use of electrochemical transient techniques to obtain thermodynamic and kinetic data on aqueous Fe(III)–1,6-dimethyl-4-hydroxy-3-pyridinecarboxylate and Fe(III)–4-hydroxy-2-methyl-3-pyridinecarboxylate complexes
  Denis Badocco,Moreno Marcon,Andrea Mondin,Annalisa Dean,Valerio B. Di Marco,Paolo Pastore Dalton Trans. 2009 2415
• 4. Solid-state identity of 2-hydroxynicotinic acid and its polymorphism
  Sihui Long,Panpan Zhou,Kathryn L. Theiss,Maxime A. Siegler,Tonglei Li CrystEngComm 2015 17 5195
• 5. Tautomer selection through solvate formation: the case of 5-hydroxynicotinic acid
  Abhinav Joseph,Joana S. Rodrigues Alves,Carlos E. S. Bernardes,M. Fátima M. Piedade,Manuel E. Minas da Piedade CrystEngComm 2019 21 2220

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

4-Hydroxypyridine-3-carboxylic Acid: An Overview of Its Properties, Applications, and Recent Research

4-Hydroxypyridine-3-carboxylic acid (CAS No. 609-70-1) is a versatile compound with significant applications in various fields, including pharmaceuticals, chemical synthesis, and materials science. This compound is characterized by its unique structure, which includes a pyridine ring with a hydroxyl group and a carboxylic acid group. The combination of these functional groups imparts distinct chemical and biological properties, making it an important molecule in both academic research and industrial applications.

The molecular formula of 4-hydroxypyridine-3-carboxylic acid is C₆H₅NO₃, and its molecular weight is 139.11 g/mol. The compound is a white crystalline solid at room temperature and is soluble in water and polar organic solvents such as methanol and ethanol. Its melting point is around 200°C, and it exhibits strong acidic properties due to the presence of the carboxylic acid group.

In the pharmaceutical industry, 4-hydroxypyridine-3-carboxylic acid has gained attention for its potential therapeutic applications. Recent studies have explored its anti-inflammatory and antioxidant properties, which could be beneficial in the treatment of various diseases. For instance, a study published in the Journal of Medicinal Chemistry in 2022 investigated the use of 4-hydroxypyridine-3-carboxylic acid derivatives as potential anti-inflammatory agents. The results showed that these derivatives effectively inhibited the production of pro-inflammatory cytokines, suggesting their potential use in treating inflammatory disorders such as arthritis.

Beyond its pharmaceutical applications, 4-hydroxypyridine-3-carboxylic acid has also been studied for its role in chemical synthesis. The compound serves as a valuable building block for the synthesis of more complex molecules. Its reactivity and functional group diversity make it an ideal starting material for various synthetic routes. For example, researchers at the University of California, Berkeley, utilized 4-hydroxypyridine-3-carboxylic acid in the synthesis of novel pyridine-based ligands for metal coordination complexes. These ligands exhibited enhanced stability and catalytic activity in various chemical reactions.

In materials science, 4-hydroxypyridine-3-carboxylic acid has been explored for its potential in developing new materials with unique properties. A study published in the Journal of Materials Chemistry A in 2021 investigated the use of 4-hydroxypyridine-3-carboxylic acid-based polymers as efficient adsorbents for heavy metal ions. The results demonstrated that these polymers had high adsorption capacities and could be used for environmental remediation purposes.

The safety profile of 4-hydroxypyridine-3-carboxylic acid is another important aspect to consider. While it is generally considered safe for laboratory use under proper handling conditions, it is essential to follow standard safety protocols to avoid any potential hazards. Proper personal protective equipment (PPE) should be worn when handling this compound, and it should be stored in a cool, dry place away from incompatible materials.

In conclusion, 4-hydroxypyridine-3-carboxylic acid (CAS No. 609-70-1) is a multifaceted compound with a wide range of applications in pharmaceuticals, chemical synthesis, and materials science. Its unique structure and properties make it an important molecule for both academic research and industrial development. Ongoing research continues to uncover new possibilities for its use, further highlighting its significance in the scientific community.

• 67367-24-2(Methyl 4-hydroxynicotinate)
• 74632-26-1(3-Pyridinecarboxylicacid, 1,4-dihydro-5-methyl-4-oxo-)
• 10177-34-1(Ethyl 4-hydroxynicotinate)
• 33821-58-8(6-Methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid)
• 142890-84-4(3-(hydroxymethyl)-4(1H)-Pyridinone)
• 177592-15-3(3-Pyridinemethanol,4-hydroxy-)
• 57905-31-4(Ethyl 4-hydroxynicotinate)
• 67367-33-3(4-Hydroxy-6-methylnicotinic acid)
• 140201-08-7(3-Pyridinecarboxylicacid, 1,4-dihydro-1-methyl-)
• 72676-96-1(3-Pyridinecarboxylicacid, 1,4-dihydro-4-oxo-)