• 1. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 2. Distribution characteristics of nitrogen and the related microbial community in the surface sediments of the Songhua River?
  Congyu Li,Wenfu Wang,Haiyan Wang,Guokai Yan,Weiyang Dong,Zhaosheng Chu,Huan Wang,Yang Chang RSC Adv., 2021,11, 26721-26731
• 3. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation
  Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
• 4. Distribution and patterns of use of food additives in foods and beverages available in Brazilian supermarkets?
  Vanessa dos Santos Pereira Montera,Camila Aparecida Borges Food Funct., 2021,12, 7699-7708
• 5. Distribution and ecological risk assessment of typical antibiotics in the surface waters of seven major rivers, China?
  Environ. Sci.: Processes Impacts, 2021,23, 1088-1100

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers

3-Ethoxy-4-hydroxybenzonitrile (CAS No. 60758-79-4): A Versatile Chemical Intermediate with Broad Applications

3-Ethoxy-4-hydroxybenzonitrile (CAS No. 60758-79-4) is an important organic compound that has gained significant attention in various industries due to its unique chemical properties and versatile applications. This aromatic nitrile derivative, characterized by its ethoxy and hydroxy functional groups, serves as a valuable building block in pharmaceutical synthesis, agrochemical production, and specialty chemical manufacturing.

The molecular structure of 3-Ethoxy-4-hydroxybenzonitrile features a benzene ring substituted with three functional groups: a nitrile (-CN) at position 1, a hydroxy (-OH) at position 4, and an ethoxy (-OCH2CH3) at position 3. This specific arrangement contributes to its moderate polarity and reactivity, making it an excellent intermediate for further chemical transformations. Researchers particularly value its electron-withdrawing nitrile group, which activates the aromatic ring for nucleophilic substitution reactions.

In the pharmaceutical industry, 3-Ethoxy-4-hydroxybenzonitrile 60758-79-4 serves as a key precursor for the synthesis of various drug molecules. Its structural features make it particularly useful in developing central nervous system (CNS) drugs and anti-inflammatory agents. Recent studies have explored its potential in creating novel neuroprotective compounds, aligning with current research trends in neurodegenerative disease treatment. The compound's ability to form hydrogen bonds through its hydroxy group enhances its biological activity and binding affinity to target proteins.

The agrochemical sector utilizes 3-ethoxy-4-hydroxy benzonitrile in the production of advanced crop protection agents. Its derivatives have shown promising results as herbicide intermediates and plant growth regulators, addressing the growing demand for sustainable agricultural solutions. With increasing global focus on food security and precision farming, this compound's role in developing next-generation agrochemicals continues to expand.

From a synthetic chemistry perspective, 3-Ethoxy-4-hydroxybenzonitrile CAS 60758-79-4 offers multiple reactive sites for chemical modification. The hydroxy group can undergo etherification or esterification, while the nitrile group can be converted to amides, acids, or tetrazoles. These transformation possibilities make it a favorite among medicinal chemists working on structure-activity relationship (SAR) studies and lead compound optimization.

Recent advancements in green chemistry have explored more sustainable production methods for 3-Ethoxy-4-hydroxybenzonitrile. Researchers are investigating catalytic processes and biocatalytic approaches to reduce environmental impact while maintaining high yield and purity. These developments respond to the chemical industry's increasing emphasis on environmentally friendly synthesis and reduced carbon footprint in manufacturing processes.

The physical properties of 3-Ethoxy-4-hydroxybenzonitrile include a melting point typically between 85-90°C and limited water solubility, though it dissolves well in common organic solvents like ethanol, acetone, and dichloromethane. These characteristics influence its handling and storage requirements, with recommendations to keep it in cool, dry conditions away from strong oxidizers. Proper material safety data should always be consulted before handling.

Analytical techniques for 3-Ethoxy-4-hydroxybenzonitrile 60758-79-4 characterization typically include HPLC for purity assessment, GC-MS for identification, and NMR spectroscopy (both 1H and 13C) for structural confirmation. Recent quality control trends emphasize the use of advanced chromatographic methods coupled with mass spectrometry to ensure batch-to-batch consistency, especially for pharmaceutical applications.

The market for 3-ethoxy-4-hydroxy benzonitrile has shown steady growth, driven by increasing demand from the pharmaceutical and agrochemical sectors. Manufacturers are focusing on process optimization to improve yields and reduce production costs. Current market analysis suggests particular growth potential in Asia-Pacific regions, where pharmaceutical and agricultural chemical production continues to expand rapidly.

Future research directions for 3-Ethoxy-4-hydroxybenzonitrile CAS No. 60758-79-4 include exploring its potential in material science applications, particularly in the development of specialty polymers and liquid crystal materials. Its aromatic structure and functional groups make it a candidate for creating novel organic electronic materials, aligning with the growing interest in flexible electronics and organic photovoltaics.

For researchers and industry professionals working with 3-Ethoxy-4-hydroxybenzonitrile, it's crucial to stay updated on the latest synthetic methodologies and application developments. The compound's versatility ensures its continued relevance across multiple chemical disciplines, from medicinal chemistry to advanced material synthesis. As regulatory requirements evolve, particularly in pharmaceutical applications, proper documentation of quality parameters and safety profiles remains essential.

• 2024-83-1(3,4-Dimethoxybenzonitrile)
• 19102-07-9(2,3-Dihydro-1,4-benzodioxine-6-carbonitrile)
• 60758-86-3(3-ethoxy-4-methoxy-benzonitrile)
• 4421-08-3(4-Hydroxy-3-methoxybenzonitrile)
• 25117-75-3(3-Ethoxybenzonitrile)
• 52805-46-6(3-hydroxy-4-methoxy-benzonitrile)
• 118132-09-5(1,2-Benzenedicarbonitrile,4,5-diethoxy-)
• 23024-83-1(3,4-dimethoxybenzoic acid nitrile)
• 60758-85-2(3-METHOXY-4-PROPOXYBENZONITRILE)
• 80407-68-7(3,4-Bis(2-methoxyethoxy)benzonitrile)