• 1. One-pot synthesis of 2-naphthols from nitrones and MBH adducts via decarboxylative N–O bond cleavage
  Sang Hoon Han,Ashok Kumar Pandey,Heeyoung Lee,Saegun Kim,Dahye Kang,Young Hoon Jung,Hyung Sik Kim,Sungwoo Hong,In Su Kim Org. Chem. Front. 2018 5 3210
• 2. Photoinduced molecular transformations. Part 145. Regioselective [3 + 2] photoadditions of 2-hydroxyphenanthrene-1,4-dione with electron-rich alkenes and phenylacetylene: new one-step synthesis of 9,10-dihydrophenanthro[2,3-b]furan-7,11-diones and 2-phenylphenanthro[2,3-b]furan-7,11-dione
  Hiroshi Suginome,Hisato Kamekawa,Hideo Sakurai,Atsushi Konishi,Hisanori Senboku,Kazuhiro Kobayashi J. Chem. Soc. Perkin Trans. 1 1994 471
• 3. A magnetic covalent organic framework as an adsorbent and a new matrix for enrichment and rapid determination of PAHs and their derivatives in PM2.5 by surface-assisted laser desorption/ionization-time of flight-mass spectrometry
  Yanhao Zhang,Yuanyuan Song,Jie Wu,Ruijin Li,Di Hu,Zian Lin,Zongwei Cai Chem. Commun. 2019 55 3745
• 4. DNA binding and cleavage properties of a newly synthesised Ru(II)-polypyridyl complex
  Amrita Ghosh,Amit Mandoli,D. Krishna Kumar,Narendra Singh Yadav,Tamal Ghosh,Bhavanath Jha,Jim A. Thomas,Amitava Das Dalton Trans. 2009 9312
• 5. A review of the analysis of biomarkers of exposure to tobacco and vaping products
  Arezoo Habibagahi,Nicholas Alderman,Cariton Kubwabo Anal. Methods 2020 12 4276

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenanthrenes and derivatives Phenanthrols

Phenanthrenol (CAS No 605-55-0): A Comprehensive Overview

Phenanthrenol, chemically identified by the compound CAS No 605-55-0, is a significant molecule in the field of organic chemistry and pharmaceutical research. This compound, belonging to the phenanthrene derivative family, has garnered considerable attention due to its unique structural properties and potential applications in medicinal chemistry. The molecular structure of Phenanthrenol consists of a fused ring system, which contributes to its distinct chemical behavior and reactivity. This introduction aims to provide a detailed exploration of Phenanthrenol, encompassing its chemical properties, synthetic pathways, and the latest research findings that highlight its relevance in contemporary scientific studies.

The chemical formula of Phenanthrenol is C??H??O, reflecting its composition of carbon, hydrogen, and oxygen atoms. The presence of an oxygen atom in its structure imparts hydrophilic characteristics, making it an interesting candidate for drug design and development. Phenanthrenol's molecular geometry and electronic distribution play a crucial role in determining its interactions with biological targets. These interactions are fundamental to understanding its pharmacological potential and how it might be utilized in the creation of novel therapeutic agents.

In terms of synthesis, Phenanthrenol can be derived through various organic reactions that manipulate the phenanthrene core. One common approach involves the oxidation of phenanthrene or its derivatives, leading to the formation of hydroxylated products such as Phenanthrenol. The synthesis process often requires careful control of reaction conditions to ensure high yield and purity. Advances in synthetic methodologies have enabled researchers to produce Phenanthrenol with greater efficiency and precision, facilitating further exploration of its applications.

Recent research has highlighted the pharmacological significance of Phenanthrenol. Studies have demonstrated its potential as a scaffold for developing new drugs due to its ability to interact with various biological receptors and enzymes. For instance, modifications to the phenanthrene ring system can alter the compound's binding affinity and selectivity, making it a versatile tool for drug discovery. Researchers are particularly interested in exploring Phenanthrenol's role in addressing neurological disorders, where its structural features may offer advantages over existing treatments.

One notable area of investigation involves Phenanthrenol's interaction with mitochondrial enzymes. Preliminary studies suggest that it may influence mitochondrial function by modulating key enzymes involved in energy production. This has implications for developing treatments for conditions associated with mitochondrial dysfunction, such as neurodegenerative diseases. The ability of Phenanthrenol to penetrate biological membranes also makes it an attractive candidate for topical applications, where direct delivery to target sites could enhance therapeutic efficacy.

The chemical stability of Phenanthrenol is another critical aspect that influences its practical applications. Research has shown that under certain conditions, Phenanthrenol exhibits remarkable stability, which is essential for pharmaceutical formulations where shelf life and bioavailability are paramount. However, understanding the factors that affect its stability is crucial for optimizing storage conditions and ensuring consistent performance in drug formulations.

Environmental considerations also play a role in the study of Phenanthrenol. Its degradation pathways and ecological impact are subjects of ongoing research to assess its environmental footprint. By understanding how Phenanthrenol behaves in different environments, scientists can develop strategies to minimize any potential negative effects while maximizing its benefits in pharmaceutical applications.

Future directions in Phenanthrenol research are likely to focus on expanding its therapeutic applications through structural modifications and combinatorial drug design. The integration of computational methods with experimental approaches will further enhance the efficiency of discovering new derivatives with improved pharmacological profiles. Collaborative efforts between academia and industry are essential to translate laboratory findings into tangible medical advancements.

In conclusion, Phenanthrenol (CAS No 605-55-0) represents a promising compound with diverse applications in pharmaceutical research. Its unique chemical properties and potential biological interactions make it a valuable candidate for developing new treatments across various medical fields. As research continues to uncover new aspects of this molecule, it is expected that Phenanthrenol will play an increasingly significant role in addressing unmet medical needs.

• 113058-38-1(Benzo[b]triphenylen-2-ol)
• 13345-26-1(Benzoapyren-8-ol)
• 17573-21-6(9-Hydroxy Benzopyrene)
• 605-87-8(3-Phenanthrol)
• 22717-95-9(3-Hydroxybenzocphenanthrene)
• 1421-80-3(Benzo[k]benz[a]anthracen-3-ol)
• 582-17-2(2,7-Dihydroxynaphthalene)
• 581-43-1(2,6-Dihydroxynaphthalene)
• 22717-94-8(2-Hydroxybenzocphenanthrene)
• 135-19-3(naphthalen-2-ol)