Cas no 60-56-0 (Methimazole)
Methimazole Chemical and Physical Properties
Names and Identifiers
-
- 1-Methyl-1H-imidazole-2(3H)-thione
- TAPAZOLE
- THIAMAZOLE
- 1,3-dihydro-1-methyl-2h-imidazole-2-thion
- 1,3-dihydro-1-methyl-2H-Imidazole-2-thione
- 1-methyl-2-mercapto-imidazol
- 1-methyl-imidazole-2-thio
- 1-Metylo 2 merkaptoimidazolem
- 2-Mercapto-1-methylimidazole
- 1-Methylimidazole-2-thiol
- Methimazole
- 1,3-Dihydro-1-Methyl-2H-iMidazole-2-thione
- 1-methyl-1H-imidazole-2-thiol
- 1-methyl-2-mercapto-imidazole
- 1-Methyl-2-MercaptoiMidazole
- 2-mercapto-1-methyl-imidazole
- Basolan
- Favistan
- Frentirox
- Mecazolyl
- mercaptomethylimidazole
- Mercazole
- Merkastan
- METAZOLE
- Metazolo
- Metizol
- Tapuzole
- thioimidazole
- 1,3-dihydro-1-methyl-2H-Imidazole-2-thione 1-methyl-imidazole-2-thio
- Mercazolyl
- Thymidazole
- Methimazol
- Thymidazol
- Thiamazol
- Thycapzol
- Metothyrine
- Metothyrin
- Merkazolil
- Mercaptazole
- Strumazol
- Thycapsol
- Metotirin
- Danantizol
- Thacapzol
- Tiamazol
- Mercasolyl
- Methylmercaptoimidazole
- Methiamazole
- Methimazolum
- Mercazolylum
- Metimazol
- Thiama
- HMS2090B17
- H10722
- NSC 38608
- Henning Berlin Brand of Methimazole
- AMY11202
- Methimazole [USAN:BAN]
- 2-mercapto-3-methylimidazole
- Thiamazole (JP17/INN)
- AB00443630_07
- BPBio1_000982
- BS-3743
- KBio2_004043
- 1-methyl-1-H-imidazole-2-thiol
- NCGC00016273-03
- Methimazole-d3(methyl-d3)
- Prestwick2_000786
- Imidazole, 1-methyl-2-mercapto-
- Thyrozol
- NCGC00094721-07
- Methimazole (Tapazole, Northyx)
- NCGC00254307-01
- 1-Methyl-2-Imidazolethione
- Methimazole, VETRANAL(TM), analytical standard
- METHIMAZOLE [USP-RS]
- 2-mecapto 1-methylimidazole
- Spectrum5_000954
- HMS3259L09
- Methamazole
- Tox21_201341
- Sanofi Synthelabo Brand of Methimazole
- THIAMAZOLE (EP MONOGRAPH)
- D0S4BR
- HMS3714M14
- M0868
- Imidazole-2-thio, 1-methyl-
- Tapazole (TN)
- A832780
- 1-Methyl-2-imidazolethiol
- Thiamazole,(S)
- HMS2097M14
- Prestwick_1010
- LS-7490
- F1679-0258
- NCGC00094721-05
- NSC-38608
- Temmler Brand of Methimazole
- IDI1_000188
- KBio1_000188
- 2-mercapto-N-methylimidazole
- 1-methylimidazole-2-thione
- THIAMAZOLE [EP MONOGRAPH]
- Mercaptizole
- CCG-220786
- NCGC00016273-01
- Methimazole, analytical standard
- AC-785
- DTXSID4020820
- BSPBio_001989
- HSDB 3361
- THIAMAZOLE [WHO-DD]
- THIAMAZOLE (MART.)
- SR-05000001672
- METHIMAZOLE (USP-RS)
- Tox21_300532
- CCG-39656
- Tiamazolo [DCIT]
- MLS002548853
- FT-0603253
- SR-05000001672-2
- SPBio_002831
- Tox21_110341_1
- N-Methyl-2-mercaptoimidazole
- NCGC00016273-02
- Q-201364
- Spectrum_000995
- STK802184
- Methimazole (USP)
- Thiamazol Hexal
- SPBio_001266
- SMR000058376
- 1-methyl-2,3-dihydro-1H-imidazole-2-thione
- 4-Imidazoline-2-thione, 1-methyl-
- Spectrum4_000048
- DTXCID20820
- METHIMAZOLE (USP MONOGRAPH)
- SR-05000001672-1
- BSPBio_000892
- DivK1c_000188
- GTPL6649
- HMS2094C05
- F0001-2396
- H03BB02
- DB00763
- 2H-Imidazol-2-tiona, 1,3-dihidro-1-metil-
- Henning, Thiamazol
- NCGC00094721-02
- METHIMAZOLE [MI]
- Jones Brand of Methimazole
- Thiamazol Henning
- Thimazol
- Methimazole [USP]
- Prestwick0_000786
- 1-Methyl-2-mercapto imidazole
- NCGC00094721-04
- Tiamazolo
- 1-methyl-3H-imidazole-2-thione
- 1-methyl-1H-immidazole-2-thiol
- SPECTRUM1500396
- Prestwick1_000786
- Thiamazole, European Pharmacopoeia (EP) Reference Standard
- Imidazole-2-thiol, 1-methyl-
- 2-Mercapto-1-methylimidazole, >=99%
- CHEMBL1515
- Felimazole
- 2-Mercaptomethylimidazole
- METHIMAZOLE [USP MONOGRAPH]
- Methymazol
- 554Z48XN5E
- Hexal Brand of Methimazole
- KBioGR_000515
- NC00636
- 1-METHYL-1H-IMIDAZOL-2-YLHYDROSULFIDE
- SW197088-3
- D00401
- MFCD00179321
- KBioSS_001475
- Thiamazol [INN-French]
- METHIMAZOLE [VANDF]
- NSC-757111
- BIDD:GT0163
- MLS000028413
- Nourypharma Brand of Methimazole
- NSC38608
- Thiamazole (JP15/INN)
- NINDS_000188
- methylimidazolethiol
- Thiamazolum
- METHIMAZOLE [ORANGE BOOK]
- SR-01000695434-2
- Methimazole, United States Pharmacopeia (USP) Reference Standard
- KBio2_001475
- HY-B0208
- Estedi Brand of Methimazole
- 1,3-Dihydro-1-Methyl-2H-Imidazol-2-Thione
- 1-Methyl-1H-imidazole-2-thiol #
- 2-Mercapto-1-methylimidazol
- NCGC00178875-01
- 1-Metylo 2 merkaptoimidazolem [Polish]
- NCGC00258893-01
- EliLilly Brand of Methimazole
- Mercazol
- THIAMAZOLE [JAN]
- 223768-14-7
- Pharmakon1600-01500396
- METHIMAZOLE [IARC]
- D0X0DI
- NCGC00094721-06
- 1-Methyl-imidazole-2-thiol
- EINECS 200-482-4
- AB00443630_06
- AI3-60285
- Philopharm Brand of Methimazole
- SBI-0206922.P004
- STR03572
- 2-Mercapto-1-methyl-1H-imidazole
- Tirodril
- Prestwick3_000786
- Tox21_110341
- 1 Methyl 2 mercaptoimidazole
- Strumazole
- BCP02147
- BDBM50241361
- SR-01000695434
- METHIMAZOLE (IARC)
- AKOS000119427
- AB00443630-04
- Merck Brand of Methimazole
- Thiamazolum [INN-Latin]
- Tiamazol [INN-Spanish]
- KBio3_001489
- MMZ
- EN300-18327
- C07190
- AB00443630-03
- NCGC00094721-03
- Methizol
- SCHEMBL41647
- HMS3651I13
- Mestinon, Regonol, Pyridostigmine Bromide
- Thimazole
- 1-Methyl-1,3-dihydroimidazole-2-thione
- UNII-554Z48XN5E
- NCGC00094721-01
- Methimazol 100 microg/mL in Acetonitrile
- Q419663
- metimazolo
- NSC757111
- 3-methyl-1H-imidazole-2-thione
- THIAMAZOLE [MART.]
- BRD-K54416256-001-15-7
- STK300018
- 60-56-0
- 1-Methylimidazole-2(3H)-thione
- 1-METHYL-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE
- HMS1920L17
- Spectrum2_001273
- KBio2_006611
- CHEBI:50673
- 2H-Imidazole-2-thione,3-dihydro-1-methyl-
- HMS1570M14
- AKOS000269708
- HMS500J10
- METHIMAZOLE [HSDB]
- Thiamazole [INN]
- Hexal, Thiamazol
- CAS-60-56-0
- Metisol
- s1609
- 2H-Imidazole-2-thione, 1,3-dihydro-1-methyl-
- HMS2091D12
- SBI-0206922.P001
- Z57901905
- N-methyl imidazole-2-thiol
- Usaf el-30
- 85916-84-3
- WLN: T5N CNJ A BSH
- tiamazole
- Spectrum3_000495
- NS00009257
- Thiamazol (INN-French)
- Tiamazol (INN-Spanish)
- Thiamazolum (INN-Latin)
- BRD-K54416256-001-18-1
- DB-053649
- BRD-K54416256-001-19-9
- Thiamazole (JP18/INN)
- imidazole, 2-mercapto-1-methyl-
-
- MDL： MFCD00179321
- Inchi： 1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)
- InChI Key： PMRYVIKBURPHAH-UHFFFAOYSA-N
- SMILES： S=C1NC=CN1C
- BRN： 108646
Computed Properties
- Exact Mass: 114.02500
- Monoisotopic Mass: 114.025
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 1
- Heavy Atom Count: 7
- Rotatable Bond Count: 0
- Complexity: 119
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: 2
- XLogP3: -0.3
- Topological Polar Surface Area: 47.4
Experimental Properties
- Color/Form: Lobular crystals.
- Density: 1.176 (estimate)
- Melting Point: 144-147?°C (lit.)
- Boiling Point: 280 oC
- Flash Point: 280°C
- Refractive Index: 1.5000 (estimate)
- Solubility: 200g/l
- Water Partition Coefficient: dissolution
- PSA: 56.62000
- LogP: 0.70880
- Solubility: Soluble in water, ethanol and chloroform, slightly soluble in ether, petroleum ether and benzene.
- Merck: 5971
Methimazole Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Warning
- Hazard Statement： H317,H361
- Warning Statement： P280
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 63-43-62
- Safety Instruction： S26-S27-S36-S45-S36/37
- RTECS：NI8615000
-
Hazardous Material Identification：
- Safety Term：S36/37
- TSCA：Yes
- HazardClass：6.1
- PackingGroup：Ⅲ
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
- Risk Phrases：R43; R62; R63
Methimazole Customs Data
- HS CODE：2933290090
- Customs Data：
China Customs Code:
2933290090Overview:
2933290090. Other compounds with non fused imidazole ring in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Methimazole Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| MedChemExpress | HY-B0208-10mM*1mLinDMSO |
Methimazole |
60-56-0 | 99.96% | 10mM*1mLinDMSO |
￥550 | 2023-07-26 | |
| MedChemExpress | HY-B0208-500mg |
Methimazole |
60-56-0 | 99.97% | 500mg |
￥500 | 2025-04-16 | |
| DC Chemicals | DC8943-1 g |
Methimazole |
60-56-0 | >98% | 1g |
$300.0 | 2022-02-28 | |
| S e l l e c k ZHONG GUO | S1609-10mM (1mL in DMSO) |
Methimazole |
60-56-0 | 100% | 10mM (1mL in DMSO) |
￥1063.18 | 2023-09-16 | |
| S e l l e c k ZHONG GUO | S1609-50mg |
Methimazole |
60-56-0 | 100% | 50mg |
￥812.03 | 2023-09-16 | |
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | PHR3037-500MG |
Methimazole |
60-56-0 | 500mg |
￥1705.78 | 2024-12-22 | ||
| Apollo Scientific | OR28714-25g |
1,3-Dihydro-1-methyl-2H-imidazole-2-thione |
60-56-0 | 25g |
￡15.00 | 2025-02-19 | ||
| Apollo Scientific | OR28714-100g |
1,3-Dihydro-1-methyl-2H-imidazole-2-thione |
60-56-0 | 100g |
￡55.00 | 2025-02-19 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | M-237-1ML |
Methimazole solution |
60-56-0 | 1ml |
￥1387.7 | 2023-10-31 | ||
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R000240-100g |
Methimazole |
60-56-0 | 98% | 100g |
￥462 | 2023-09-08 |
Methimazole Suppliers
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Methimazole Related Literature
-
Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
-
Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
-
Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
-
4. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imagingGhazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
-
Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
Additional information on Methimazole
Introduction to Methimazole (CAS No: 60-56-0)
Methimazole, chemically known as 1,2-dihydro-5-imidazol-4-ylthiazole, is a synthetic compound with the chemical formula C?H?N?S. Its CAS number is 60-56-0, which uniquely identifies it in the chemical industry and research communities. This compound has garnered significant attention in the field of pharmaceuticals due to its therapeutic properties, particularly in the treatment of hyperthyroidism.
The Methimazole molecule belongs to the thiazole class of heterocyclic compounds, characterized by a sulfur atom and a nitrogen atom in its five-membered ring structure. This unique configuration imparts distinct chemical and biological properties to the compound, making it a versatile candidate for various medical applications. The synthesis of Methimazole involves a series of well-defined chemical reactions that ensure high purity and yield, which are critical for pharmaceutical-grade production.
In recent years, Methimazole has been extensively studied for its mechanism of action and potential therapeutic benefits beyond its primary use in hyperthyroidism. Research has shown that Methimazole exerts its effects by inhibiting the enzyme thyroid peroxidase, which is crucial for the synthesis of thyroid hormones. This mechanism has opened up new avenues for exploring its efficacy in other metabolic disorders and autoimmune conditions.
One of the most compelling aspects of Methimazole is its role in clinical trials investigating novel therapeutic strategies. For instance, studies have explored its potential in combination therapies with other antithyroid drugs to enhance treatment outcomes. Additionally, researchers are examining its effects on inflammatory pathways, suggesting that Methimazole might have applications in managing certain inflammatory diseases. These findings highlight the compound's broad therapeutic potential and underscore the importance of continued research.
The pharmacokinetic profile of Methimazole is another area of active investigation. Studies have revealed that the compound exhibits moderate oral bioavailability and a relatively long half-life, allowing for once-daily dosing in many clinical scenarios. This characteristic makes it a convenient option for patients requiring long-term treatment. Furthermore, research into drug metabolism has identified key enzymes involved in the biotransformation of Methimazole, providing insights into potential drug-drug interactions and optimizing dosing regimens.
From a chemical perspective, the structural features of Methimazole make it an interesting subject for medicinal chemistry modifications. Researchers are exploring analogs of Methimazole with enhanced binding affinity and reduced side effects. These efforts aim to develop next-generation antithyroid agents that maintain efficacy while improving safety profiles. The development of such derivatives could significantly impact patient care and open up new treatment modalities.
The regulatory landscape for Methimazole is well-established, with the compound being approved by major regulatory agencies worldwide for the treatment of hyperthyroidism. However, ongoing research continues to refine dosing guidelines and expand its approved indications. This evolving landscape reflects the dynamic nature of pharmaceutical science and underscores the importance of continuous monitoring and evaluation.
Environmental considerations also play a role in the production and use of Methimazole. Efforts are underway to develop sustainable synthetic routes that minimize waste and reduce environmental impact. These initiatives align with global trends toward green chemistry and sustainable practices, ensuring that pharmaceutical compounds like Methimazole are produced responsibly.
In conclusion, Methimazole (CAS No: 60-56-0) is a multifaceted compound with significant therapeutic potential beyond its primary use in hyperthyroidism. Its unique chemical structure, well-characterized mechanism of action, and ongoing research make it a cornerstone in modern pharmaceuticals. As scientific understanding advances, new applications and improvements for Methimazole are likely to emerge, further solidifying its importance in medical science.
60-56-0 (Methimazole) Related Products
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