• 1. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
• 2. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
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• 3. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
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• 4. An amino group functionalized metal–organic framework as a luminescent probe for highly selective sensing of Fe3+ ions?
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• 5. An antimonate pyrochlore (H1.23Sr0.45SbO3.48) for photocatalytic oxidation of benzene: effective oxygen usage and excellent activity?
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Methyl 2-Amino-3-(4-Fluorophenyl)Propanoate: A Comprehensive Overview

Methyl 2-amino-3-(4-fluorophenyl)propanoate, with the CAS number 59850-77-0, is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound is characterized by its unique structure, which combines an amino group, a fluorophenyl substituent, and a methyl ester moiety. The combination of these functional groups makes it a versatile molecule with potential applications in drug design and chemical synthesis.

Recent studies have highlighted the importance of methyl 2-amino-3-(4-fluorophenyl)propanoate in the development of bioactive compounds. Researchers have explored its role as an intermediate in the synthesis of various pharmaceutical agents, particularly those targeting central nervous system disorders. The presence of the fluorophenyl group enhances the molecule's lipophilicity, which is crucial for its ability to cross biological membranes and interact with target receptors.

The synthesis of methyl 2-amino-3-(4-fluorophenyl)propanoate involves a multi-step process that typically begins with the preparation of the corresponding carboxylic acid derivative. This is followed by esterification to introduce the methyl group. The amino group is introduced via nucleophilic substitution or other suitable methods, depending on the starting materials and desired stereochemistry. The fluorophenyl substituent is incorporated through aromatic substitution reactions, often requiring specific catalysts to achieve high yields and selectivity.

One of the most promising applications of methyl 2-amino-3-(4-fluorophenyl)propanoate lies in its use as a building block for peptide-based drugs. Its amino group allows for easy incorporation into peptide chains, while the fluorophenyl group provides additional functionality for optimizing pharmacokinetic properties. Recent research has demonstrated its utility in constructing bioactive peptides with enhanced stability and bioavailability.

In addition to its role in drug development, methyl 2-amino-3-(4-fluorophenyl)propanoate has been investigated for its potential in materials science. Its ability to form stable amide bonds makes it a candidate for synthesizing novel polymers and materials with tailored properties. Researchers have explored its use in creating biodegradable polymers for biomedical applications, such as drug delivery systems and tissue engineering scaffolds.

The physical properties of methyl 2-amino-3-(4-fluorophenyl)propanoate are also worth noting. It exists as a crystalline solid at room temperature, with a melting point of approximately 125°C. Its solubility in common organic solvents such as dichloromethane and ethyl acetate makes it suitable for various synthetic procedures. The compound is stable under normal storage conditions but should be protected from moisture and light to prevent degradation.

From a toxicological perspective, methyl 2-amino-3-(4-fluorophenyl)propanoate has been subjected to preliminary safety assessments. Studies indicate that it exhibits low acute toxicity when administered orally or intravenously. However, further research is required to fully understand its long-term effects and potential for bioaccumulation.

In conclusion, methyl 2-amino-3-(4-fluorophenyl)propanoate (CAS No: 59850-77-0) is a versatile compound with diverse applications in organic synthesis, pharmacology, and materials science. Its unique structure and functional groups make it an invaluable tool for researchers seeking to develop innovative chemical entities. As ongoing studies continue to uncover new insights into its properties and potential uses, this compound is poised to play an increasingly important role in various scientific disciplines.

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