• 1. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 2. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 3. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 4. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 5. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indolecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indolecarboxylic acids and derivatives Indolecarboxylic acids

Comprehensive Overview of Methyl 4-iodo-1H-indole-6-carboxylate (CAS No. 597562-19-1): Properties, Applications, and Industry Insights

Methyl 4-iodo-1H-indole-6-carboxylate (CAS No. 597562-19-1) is a specialized indole derivative with significant relevance in pharmaceutical and organic synthesis. This compound, characterized by its iodo-substituted indole core and methyl ester functional group, serves as a versatile intermediate in drug discovery and material science. Its molecular structure, C₁₀H₈INO₂, offers unique reactivity patterns, making it invaluable for cross-coupling reactions and heterocyclic chemistry.

In recent years, the demand for functionalized indoles like Methyl 4-iodo-1H-indole-6-carboxylate has surged due to their role in developing targeted therapies and small-molecule inhibitors. Researchers frequently search for "indole-based drug scaffolds" or "iodo-indole synthesis," reflecting its prominence in medicinal chemistry. The compound’s iodine atom enables palladium-catalyzed reactions, such as Suzuki-Miyaura couplings, which are pivotal for creating biaryl structures in oncology and CNS drug candidates.

From a synthetic perspective, Methyl 4-iodo-1H-indole-6-carboxylate is often synthesized via direct iodination of methyl indole-6-carboxylate, followed by purification through column chromatography. Its crystalline solid form and stability under inert conditions make it suitable for high-throughput screening (HTS) workflows. Industry professionals frequently inquire about "scalable indole derivatization" or "CAS 597562-19-1 suppliers," highlighting its commercial importance.

Beyond pharmaceuticals, this compound finds niche applications in agrochemical research and fluorescence probes. Its electron-rich aromatic system allows for modifications to enhance photophysical properties, a topic gaining traction in "organic electronics" forums. Environmental considerations also drive interest in "green synthesis of halogenated indoles," where 597562-19-1 serves as a model for optimizing atom economy.

Analytical characterization of Methyl 4-iodo-1H-indole-6-carboxylate typically involves NMR spectroscopy (1H/13C), mass spectrometry, and HPLC purity assays. Recent publications emphasize its utility in "fragment-based drug design" (FBDD), addressing queries like "how to modify indole C4 position." Regulatory compliance, such as REACH and GMP standards, further underscores its safe handling protocols.

In conclusion, Methyl 4-iodo-1H-indole-6-carboxylate (CAS No. 597562-19-1) exemplifies the intersection of structural complexity and practical utility in modern chemistry. As AI-driven platforms like AlphaFold accelerate molecular modeling, compounds like this will remain pivotal in bridging computational predictions with laboratory validation. Future trends may explore its role in "deuterated pharmaceuticals" or "catalytic C-H activation," ensuring sustained scientific and commercial interest.

• 104669-32-1(1H-Indole-3-carboxylic acid, 4-iodo-, butyl ester)
• 101909-44-8(4-Iodo-1H-indole-3-carboxylic acid methyl ester)
• 1227269-05-7(Methyl 5-iodo-1h-indole-6-carboxylate)
• 1788043-93-5(Methyl 3-iodo-1H-indole-7-carboxylate)
• 104669-30-9(1H-Indole-3-carboxylic acid, 4-iodo-, ethyl ester)
• 724450-23-1(4-Iodo-1H-indole-6-carboxylic acid)
• 1228600-24-5(3-iodo-1H-indole-6-carboxylic acid)
• 50820-65-0(Methyl 1H-indole-6-carboxylate)
• 26000-33-9(Methyl 9H-carbazole-2-carboxylate)
• 850374-98-0(Methyl 3-iodo-1H-indole-6-carboxylate)