• 1. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
• 2. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584
• 3. Aggregation-induced emission leading to two distinct emissive species in the solid-state structure of high-dipole organic chromophores?
  Felix Witte,Philipp Rietsch,Nithiya Nirmalananthan-Budau,Florian Weigert,Jan P. G?tze,Ute Resch-Genger,Siegfried Eigler,Beate Paulus Phys. Chem. Chem. Phys., 2021,23, 17521-17529
• 4. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644
• 5. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782

• Solvents and Organic Chemicals Organic Compounds Alkaloids and derivatives Cinchona alkaloids Cinchona alkaloids
• Solvents and Organic Chemicals Organic Compounds Alkaloids and derivatives Cinchona alkaloids
• Catalysts and Inorganic Chemicals Catalysts

Comprehensive Guide to Cinchonine Hydrochloride (CAS No. 5949-11-1): Properties, Applications, and Research Insights

Cinchonine hydrochloride (CAS No. 5949-11-1) is a well-known alkaloid derivative widely utilized in pharmaceutical research, organic synthesis, and biochemical studies. This compound, derived from the bark of Cinchona trees, has garnered significant attention due to its unique chiral properties and potential therapeutic applications. In this article, we delve into the molecular structure, synthesis methods, and cutting-edge applications of cinchonine HCl, while addressing frequently asked questions and trending topics in the scientific community.

The chemical formula of cinchonine hydrochloride is C₁₉H₂₂N₂O·HCl, with a molecular weight of 322.85 g/mol. Its crystalline form and high solubility in water make it a preferred choice for laboratory experiments. Researchers often seek cinchonine HCl suppliers or inquire about its purity standards, as these factors critically impact experimental reproducibility. Recent studies highlight its role as a chiral auxiliary in asymmetric catalysis, a topic trending in green chemistry discussions.

One of the most searched questions about CAS 5949-11-1 relates to its distinction from similar alkaloids like quinine or quinidine. While structurally related, cinchonine hydrochloride exhibits distinct stereochemistry at C8 and C9 positions, influencing its biological activity. This specificity makes it valuable for studying enzyme inhibition mechanisms or designing novel drug candidates. Current research explores its potential in antimalarial drug development, aligning with global health priorities.

From an industrial perspective, the synthesis of cinchonine HCl involves careful optimization to achieve high enantiomeric excess. Manufacturers emphasize GMP compliance and analytical validation, responding to the pharmaceutical industry's demand for reliable intermediates. Analytical techniques like HPLC purity testing and chiral separation methods are frequently discussed in quality control forums, reflecting users' practical concerns.

Emerging applications of 5949-11-1 extend to material science, where its molecular recognition properties aid in designing selective sensors. The compound's fluorescence characteristics also attract interest in bioimaging research. Such interdisciplinary applications demonstrate why search terms like "cinchonine hydrochloride solubility" or "stability under various pH" remain popular among researchers.

Storage and handling of cinchonine hydrochloride require attention to moisture control, as indicated by its hygroscopic nature. Safety data sheets recommend airtight containers with desiccants—a practical detail often overlooked in academic literature but highly relevant for laboratory personnel searching for "cinchonine HCl storage conditions."

The global market for CAS 5949-11-1 reflects growing demand from both academic institutions and pharmaceutical companies. Pricing trends correlate with Cinchona bark availability and synthetic alternatives' development. Sustainability-conscious buyers increasingly inquire about eco-friendly extraction methods, mirroring broader trends in natural product sourcing.

In conclusion, cinchonine hydrochloride represents a fascinating intersection of traditional medicine and modern science. Its versatility continues to inspire research across multiple disciplines, from medicinal chemistry to catalysis engineering. As analytical techniques advance and biological targets become more precisely defined, the scientific community's interest in this chiral building block shows no signs of diminishing.

• 485-64-3(Cinchamidine)
• 70877-75-7(O-Desmethyl Quinidine)
• 118-10-5(Cinchonine)
• 485-71-2(Cinchonidine)
• 524-63-0(4-[(R)-hydroxy-[(1S,2S,4S,5R)-5-vinylquinuclidin-2-yl]methyl]quinolin-6-ol)
• 485-65-4(Hydrocinchonin)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)