• 1. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 2. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 3. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 4. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 5. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962

• Solvents and Organic Chemicals Organic Compounds Organohalogen compounds Alkyl halides Cyclohexyl halides

4-Chlorocyclohexan-1-Amine: A Comprehensive Overview

4-Chlorocyclohexan-1-amine (CAS No. 59477-35-9) is a versatile organic compound with significant applications in various fields, including pharmaceuticals, agrochemicals, and materials science. This compound is characterized by its cyclohexane ring structure, which is substituted with a chlorine atom at the 4-position and an amine group at the 1-position. The unique combination of these functional groups imparts 4-chlorocyclohexan-1-amine with distinct chemical properties, making it a valuable intermediate in synthetic chemistry.

The synthesis of 4-chlorocyclohexan-1-amine typically involves multi-step processes that leverage the reactivity of cyclohexane derivatives. Recent advancements in catalytic methods have enabled more efficient and environmentally friendly syntheses, reducing production costs and minimizing waste. For instance, researchers have explored the use of transition metal catalysts to facilitate the coupling reactions required for constructing the amine functionality. These innovations highlight the growing emphasis on sustainable practices in chemical manufacturing.

One of the most notable applications of 4-chlorocyclohexan-1-amine is in the development of pharmaceutical agents. The compound serves as a key intermediate in the synthesis of various bioactive molecules, including anti-inflammatory drugs and antiviral agents. For example, studies have shown that derivatives of 4-chlorocyclohexan-1-amine exhibit potent inhibitory effects against enzymes involved in inflammatory pathways, offering potential therapeutic benefits for conditions such as arthritis and neurodegenerative diseases.

In addition to its pharmaceutical applications, 4-chlorocyclohexan-1-amine has found utility in agrochemical research. Its ability to act as a precursor for herbicides and fungicides has made it an important component in crop protection products. Recent research has focused on optimizing the bioavailability and efficacy of these compounds, ensuring they meet stringent environmental and safety standards.

The chemical properties of 4-chlorocyclohexan-1-amine are heavily influenced by its molecular structure. The cyclohexane ring provides structural rigidity, while the chlorine substituent introduces electron-withdrawing effects that enhance reactivity. This combination makes the compound highly amenable to various nucleophilic and electrophilic reactions, enabling its use in a wide range of synthetic transformations.

From a materials science perspective, 4-chlorocyclohexan-1-amine has been explored as a building block for advanced polymers and materials with tailored properties. Its ability to participate in polymerization reactions under mild conditions has opened new avenues for developing high-performance materials for applications in electronics, textiles, and biomedical devices.

Recent studies have also investigated the environmental fate and toxicity of 4-chlorocyclohexan-1-amine, particularly in relation to its potential impact on aquatic ecosystems. Researchers have developed novel analytical methods to monitor trace levels of this compound in environmental samples, ensuring compliance with regulatory standards and promoting sustainable practices.

In conclusion, 4-chlorocyclohexan-1-amine (CAS No. 59477-35-9) is a multifaceted compound with significant implications across diverse industries. Its unique chemical properties, coupled with ongoing advancements in synthesis and application techniques, continue to drive innovation and expand its utility in modern chemistry.

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