• 1. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 2. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 3. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 4. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 5. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzopyrazoles Indazoles

Comprehensive Overview of 4-Bromo-2-methyl-2H-indazole (CAS No. 590417-93-9): Properties, Applications, and Market Trends

4-Bromo-2-methyl-2H-indazole (CAS No. 590417-93-9) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. This brominated indazole derivative is characterized by its unique molecular structure, combining a bromine substituent with a methyl group at the 2-position of the indazole ring. Its chemical formula C8H7BrN2 and molecular weight of 211.06 g/mol make it a versatile intermediate in organic synthesis.

The compound's high purity grade (>98%) and stability under controlled conditions have made it a valuable building block for drug discovery. Researchers are particularly interested in its potential as a kinase inhibitor scaffold, a topic frequently searched in AI-driven drug development platforms. Recent studies highlight its role in modulating enzyme activity, with applications being explored in metabolic disorder research—a trending topic in 2023 biomedical literature.

From a synthetic chemistry perspective, 4-Bromo-2-methyl-2H-indazole offers distinct advantages. Its bromine atom serves as an excellent leaving group for cross-coupling reactions, particularly in palladium-catalyzed transformations such as Suzuki-Miyaura couplings. This property aligns with current industry demands for efficient C-C bond formation methodologies, as evidenced by rising Google Scholar citations for "brominated heterocycle coupling reactions."

The compound's crystallographic data reveals interesting packing patterns, with hydrogen bonding networks that influence its solubility profile—a critical parameter frequently queried in chemical databases. Analytical techniques like HPLC and LC-MS are commonly employed for quality control, addressing another common search trend among quality assurance professionals seeking "indazole characterization methods."

Market analysts note growing demand for 4-Bromo-2-methyl-2H-indazole in Asia-Pacific research centers, correlating with increased patent filings for indazole-based therapeutics. This regional trend reflects broader movements in precision medicine development, where customized molecular scaffolds are essential. The compound's structure-activity relationship (SAR) potential makes it particularly valuable for medicinal chemistry applications—a subject generating over 5,000 monthly searches on scientific platforms.

Environmental and handling considerations for 590417-93-9 follow standard laboratory protocols for brominated compounds. While not classified as hazardous under current regulations, proper personal protective equipment (PPE) is recommended during handling—a safety aspect increasingly emphasized in online chemical safety courses. Storage typically requires protection from light at 2-8°C, with stability data showing excellent shelf life when properly maintained.

Emerging applications in material science have expanded the compound's utility beyond life sciences. Its incorporation into organic electronic materials is being investigated for potential use in OLED technologies—a hot topic in materials science forums. The bromine moiety's ability to participate in polymerization reactions opens possibilities for novel conductive polymers, addressing another frequent search query regarding "heterocyclic monomers for electronics."

Quality specifications for research-grade 4-Bromo-2-methyl-2H-indazole typically include ≥95% HPLC purity with stringent controls on residual solvents—parameters that align with current Good Manufacturing Practice (cGMP) standards for pharmaceutical intermediates. This quality assurance aspect generates substantial discussion in online chemistry communities focused on "API intermediate specifications."

The compound's spectroscopic properties make it identifiable through characteristic NMR peaks (1H NMR: δ 7.5-7.8 ppm for aromatic protons, 4.2 ppm for methyl group) and mass spectral patterns—analytical data frequently requested in chemical vendor portals. These identification methods satisfy the growing demand for "compound authentication techniques" among research purchasers.

Looking forward, 4-Bromo-2-methyl-2H-indazole is poised to maintain its relevance in cutting-edge research. Its combination of structural versatility and synthetic accessibility addresses two key requirements in modern drug discovery—a connection frequently made in recent webinar discussions about "next-generation heterocyclic building blocks." As the scientific community continues exploring indazole pharmacology, this compound's role in developing targeted therapies is expected to expand significantly.

• 465529-57-1(5-Bromo-1-methyl-1H-indazole)
• 1159511-86-0(4-Bromo-2,5-dimethyl-2H-indazole)
• 1159511-77-9(4-Bromo-1,5-dimethyl-1H-indazole)
• 1000576-59-9(7-Bromo-1-methyl-1H-indazole)
• 590417-94-0(6-Bromo-1-methyl-1H-indazole)
• 701910-14-7(7-Bromo-2-methyl-2H-indazole)
• 52088-11-6(3,5-dibromo-1-methyl-indazole)
• 465529-56-0(5-Bromo-2-methyl-2H-indazole)
• 590417-95-1(6-Bromo-2-methyl-2H-indazole)
• 365427-30-1(4-Bromo-1-methyl-1H-indazole)