• 1. Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis
  Jelena Pesek,Ji?í Svoboda,Martina Sattler,Stefan Bartram,Wilhelm Boland Org. Biomol. Chem. 2015 13 178
• 2. Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis
  Jelena Pesek,Ji?í Svoboda,Martina Sattler,Stefan Bartram,Wilhelm Boland Org. Biomol. Chem. 2015 13 178
• 3. Photoinduced tautomeric transformations of xanthurenic acid
  Vadim V. Yanshole,Peter S. Sherin,Nina P. Gritsan,Olga A. Snytnikova,Victor I. Mamatyuk,Jakob Grilj,Eric Vauthey,Renad Z. Sagdeev,Yuri P. Tsentalovich Phys. Chem. Chem. Phys. 2010 12 9502
• 4. TiO2 modified with a Ru(ii)–N′NN′ 8-hydroxyquinolyl complex for efficient gaseous photoreduction of CO2
  Wenjing Xiang,Lin Li,Zengjin Dai,Xianggao Meng,Renjie Li,Jing Zhang,Tianyou Peng Catal. Sci. Technol. 2018 8 2098
• 5. Electrochemically reduced graphene oxide-enhanced electropolymerization of poly-xanthurenic acid for direct, “signal-on” and high sensitive impedimetric sensing of DNA
  Tao Yang,Xiao Li,Qianhe Li,Xiuhong Guo,Qian Guan,Kui Jiao Polym. Chem. 2013 4 1228

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinoline carboxylic acids

Xanthurenic Acid (CAS No. 59-00-7): A Comprehensive Guide to Its Biological Significance and Research Applications

Xanthurenic acid (CAS No. 59-00-7), a metabolite of tryptophan, has garnered significant attention in recent years due to its multifaceted roles in human physiology and disease. This kynurenine pathway intermediate is not only a biomarker for vitamin B6 deficiency but also a potential modulator of neurodegenerative disorders and immune responses. Researchers are increasingly exploring its antioxidant properties and metal-chelating abilities, making it a hot topic in biomedical research and nutritional science.

The growing interest in xanthurenic acid is evident from its frequent appearance in searches related to gut-brain axis interactions and mitochondrial dysfunction. Many users inquire about its connection to aging processes and metabolic syndrome, reflecting contemporary health concerns. Its CAS registry number 59-00-7 is often searched alongside terms like tryptophan metabolism and kynurenine pathway inhibitors, highlighting its importance in biochemical pathways.

Recent studies have revealed that xanthurenic acid exhibits unique fluorescence properties, making it valuable for analytical chemistry applications. Its ability to form complexes with divalent cations has sparked investigations into its role in metal homeostasis. Furthermore, the compound's potential as a diagnostic marker for certain neurological conditions has become a key area of exploration, particularly in the context of Alzheimer's disease research and Parkinson's disease biomarkers.

In the field of nutritional biochemistry, xanthurenic acid (CAS 59-00-7) serves as an important indicator of tryptophan metabolism status. The compound's accumulation is closely associated with vitamin B6-dependent enzymes, leading to its use in assessing nutritional deficiencies. Current research trends focus on its potential as a therapeutic target for inflammatory diseases and its interactions with gut microbiota, topics that consistently rank high in scientific literature searches.

The analytical methods for detecting xanthurenic acid have evolved significantly, with high-performance liquid chromatography (HPLC) and mass spectrometry techniques now enabling precise quantification in biological samples. These advancements have facilitated studies examining its concentration fluctuations in various physiological states and disease conditions. The compound's redox activity and potential neuroprotective effects continue to be subjects of intense investigation.

From a structural perspective, xanthurenic acid (CAS 59-00-7) possesses unique chemical features that contribute to its biological activities. Its aromatic system and carboxylic acid group allow for diverse molecular interactions, while its planar structure facilitates binding to various protein targets. These characteristics have led to exploration of its potential in drug development, particularly for conditions involving oxidative stress and neuroinflammation.

Emerging evidence suggests that xanthurenic acid may play a role in circadian rhythm regulation, adding another layer to its biological significance. This connection to sleep-wake cycles has generated considerable interest, as evidenced by search trends combining the compound with terms like melatonin synthesis and chronobiology. Such findings position xanthurenic acid as a potential link between metabolic pathways and behavioral regulation.

In clinical research, the measurement of xanthurenic acid levels has proven valuable for understanding tryptophan metabolism disorders. The compound's association with diabetes complications and cardiovascular risk factors has made it a subject of numerous epidemiological studies. Researchers are particularly interested in its potential as a predictive biomarker for certain chronic diseases, reflecting the current emphasis on preventive medicine approaches.

The synthetic pathways and biosynthesis regulation of xanthurenic acid (CAS 59-00-7) represent active areas of investigation in molecular biology. Scientists are examining the enzyme kinetics involved in its production and degradation, with particular focus on IDO/TDO enzymes and their inflammatory modulation effects. These studies contribute to our understanding of how tryptophan catabolism influences overall physiological homeostasis.

As research on xanthurenic acid continues to expand, its potential applications in personalized medicine and nutritional interventions are becoming increasingly apparent. The compound's multifaceted roles in cellular signaling and metabolic regulation position it as a promising subject for future translational research. With growing recognition of its importance in systems biology, xanthurenic acid (CAS 59-00-7) remains at the forefront of biochemical research and medical innovation.

• 1571-30-8(8-Hydroxyquinoline-2-carboxylic acid)
• 345909-35-5(Kynurenic Acid Hydrate)
• 492-27-3(Kynurenic acid)
• 149312-98-1(5-oxo-1,5-dihydroquinoline-2-carboxylic acid)
• 84639-84-9(7-Hydroxy-1H-indole-2-carboxylic acid)
• 15733-83-2(4-Methoxyquinoline-2-carboxylic acid)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)