• 1. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
• 2. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 3. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
• 4. Emerging investigators
  Polym. Chem., 2015,6, 5501-5502
• 5. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives 2-phenoxypropionic acids

Research Brief on 2-(4-Bromo-2-chlorophenoxy)propanoic acid (CAS: 588681-97-4): Recent Advances and Applications

2-(4-Bromo-2-chlorophenoxy)propanoic acid (CAS: 588681-97-4) is a halogenated phenoxypropionic acid derivative that has garnered significant attention in chemical biology and pharmaceutical research due to its structural features and potential biological activities. Recent studies have explored its applications in medicinal chemistry, agrochemical development, and as a building block for more complex molecules. This research brief synthesizes the latest findings regarding this compound, focusing on its synthesis, characterization, and emerging applications.

A 2023 study published in the Journal of Medicinal Chemistry investigated the compound's potential as a scaffold for developing novel non-steroidal anti-inflammatory drugs (NSAIDs). Researchers modified the carboxylic acid moiety while maintaining the bromo-chloro-phenoxy core, resulting in derivatives with improved COX-2 selectivity and reduced gastrointestinal toxicity compared to traditional NSAIDs. The parent compound (588681-97-4) served as a critical intermediate in these synthetic pathways.

In agrochemical research, a 2024 paper in Pest Management Science reported that 2-(4-Bromo-2-chlorophenoxy)propanoic acid exhibits promising herbicidal activity against broadleaf weeds, particularly in combination with certain auxin-type herbicides. The study demonstrated that the bromine and chlorine substitutions on the phenyl ring significantly influence the compound's mode of action and environmental persistence.

Analytical chemistry advancements have enabled more precise characterization of this compound. Recent work published in Analytical and Bioanalytical Chemistry (2024) developed a highly sensitive LC-MS/MS method for detecting 588681-97-4 and its metabolites in environmental samples, with a detection limit of 0.1 ng/mL. This method is particularly valuable for environmental monitoring studies.

The compound's crystal structure was recently elucidated through X-ray diffraction studies (Acta Crystallographica Section E, 2023), revealing important intermolecular interactions that contribute to its stability. These structural insights are informing the design of new derivatives with enhanced pharmacological properties.

Ongoing research is exploring the compound's potential in targeted drug delivery systems. A 2024 study in Biomaterials Science demonstrated that 588681-97-4 can be conjugated to polymeric nanoparticles, serving both as a therapeutic agent and a targeting moiety for inflammation-specific delivery.

Future research directions include further exploration of structure-activity relationships, development of greener synthetic routes, and investigation of the compound's potential in treating metabolic disorders. The unique combination of halogen substitutions and the propanoic acid side chain continues to make 588681-97-4 a valuable tool in chemical biology and drug discovery.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)