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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Tertiary amines
• Catalysts and Inorganic Chemicals Inorganic Compounds Salt

Comprehensive Overview of 4-(Dimethylamino)phenol Hydrochloride (CAS No. 5882-48-4): Properties, Applications, and Research Insights

4-(Dimethylamino)phenol hydrochloride (CAS No. 5882-48-4) is a versatile organic compound with significant relevance in chemical synthesis and biomedical research. This compound, often abbreviated as DMAP hydrochloride, features a phenol core substituted with a dimethylamino group and is stabilized as a hydrochloride salt. Its molecular structure (C₈H₁₂NO⁺·Cl^-) grants it unique physicochemical properties, including high solubility in water and polar solvents, making it a valuable intermediate in pharmaceuticals and material science.

In recent years, the demand for 4-(dimethylamino)phenol derivatives has surged due to their role in photocatalysis and organic electronics. Researchers highlight its potential in dye-sensitized solar cells (DSSCs), where its electron-donating dimethylamino group enhances light absorption efficiency. Additionally, its application in antioxidant studies has garnered attention, particularly in exploring mechanisms to mitigate oxidative stress in biological systems.

The synthesis of CAS 5882-48-4 typically involves the reaction of 4-aminophenol with dimethyl sulfate, followed by hydrochloride salt formation. Analytical techniques like HPLC and NMR spectroscopy are employed to verify purity, which is critical for pharmaceutical-grade applications. Recent Google Scholar trends indicate growing interest in "green synthesis methods" for such compounds, aligning with the global push toward sustainable chemistry.

From a commercial perspective, 4-(dimethylamino)phenol HCl is cataloged by major suppliers like Sigma-Aldrich and TCI Chemicals, with purity grades ranging from 95% to 99%. Pricing fluctuates based on demand in niche sectors such as fluorescent probes and polymeric materials. Notably, its UV-visible absorption properties (λ_max ~300 nm) make it a candidate for sensor development, a topic frequently queried in AI-driven research databases.

Safety data for 5882-48-4 emphasize standard laboratory precautions, including glove use and ventilation. While not classified as hazardous under most regulations, its material safety data sheet (MSDS) recommends avoiding prolonged exposure. This aligns with PubMed literature underscoring its low acute toxicity in controlled environments.

Future directions for DMAP hydrochloride research include optimizing its role in photodynamic therapy and nanomaterial functionalization. As SciFinder search trends reveal, combining this compound with metallic nanoparticles could unlock advancements in cancer imaging. Such interdisciplinary applications position CAS No. 5882-48-4 as a compound of enduring scientific and industrial interest.

• 140165-63-5(Phenol, 3,3'-[1,4-phenylenebis(phenylimino)]bis-)
• 150-75-4(4-(Methylamino)phenol)
• 99-07-0(3-(Dimethylamlno)phenol)
• 64051-05-4(Benzenaminium,4-hydroxy-N,N,N-trimethyl-, bromide (1:1))
• 154286-35-8(Phenoxy, 3-(dimethylamino)-)
• 6358-22-1(Phenol,4-[[4-(dimethylamino)phenyl]amino]-)
• 3483-84-9(Benzenaminium,3-hydroxy-N,N,N-trimethyl-)
• 2498-27-3(3-Hydroxyphenyltrimethylammonium Iodide)
• 619-60-3(4-(Dimethylamino)phenol)
• 64050-96-0(1,3-Benzenediaminium,5-hydroxy-N1,N1,N1,N3,N3,N3-hexamethyl-, chloride (1:2))