• 1. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 2. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 3. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 4. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 5. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847

Introduction to 3-Methoxy-2-(prop-2-yn-1-yloxy)benzaldehyde (CAS No. 58758-45-5)

3-Methoxy-2-(prop-2-yn-1-yloxy)benzaldehyde, identified by the Chemical Abstracts Service registry number 58758-45-5, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and synthetic biology due to its unique structural and functional properties. This compound belongs to the class of aryl aldehydes, characterized by the presence of both a benzaldehyde moiety and an alkyne functional group, which together contribute to its reactivity and potential applications in drug discovery and material science.

The molecular structure of 3-Methoxy-2-(prop-2-yn-1-yloxy)benzaldehyde consists of a benzene ring substituted with a methoxy group at the 3-position and an oxypropyne group at the 2-position. This arrangement imparts distinct chemical characteristics, making it a valuable intermediate in organic synthesis. The presence of the prop-2-ynyl (alkyne) group allows for further functionalization via cross-coupling reactions, such as Suzuki or Heck couplings, which are widely employed in the construction of complex molecular architectures.

In recent years, there has been growing interest in the development of novel bioactive molecules derived from aryl aldehydes due to their role as key intermediates in the synthesis of pharmaceuticals. 3-Methoxy-2-(prop-2-yn-1-yloxy)benzaldehyde has been explored in several research studies for its potential applications in medicinal chemistry. Its aldehyde functionality serves as a versatile handle for further derivatization, enabling the creation of diverse pharmacophores. For instance, it has been utilized in the synthesis of heterocyclic compounds that exhibit promising biological activities.

One notable area of research involving 3-Methoxy-2-(prop-2-yn-1-yloxy)benzaldehyde is its incorporation into natural product-inspired scaffolds. Researchers have leveraged its structural features to develop analogs of known bioactive agents, aiming to enhance their efficacy and reduce toxicity. The methoxy group provides electronic modulation, while the propynyl ether moiety introduces conformational flexibility, both of which are critical factors in optimizing drug-like properties.

The compound's reactivity also makes it a valuable tool in materials science. For example, it has been employed in the synthesis of conjugated polymers and organic semiconductors due to its ability to undergo polymerization reactions under controlled conditions. These materials find applications in optoelectronic devices such as organic light-emitting diodes (OLEDs) and photovoltaic cells.

Recent advancements in synthetic methodologies have further expanded the utility of 3-Methoxy-2-(prop-2-yn-1-yloxy)benzaldehyde. Transition-metal-catalyzed reactions have enabled more efficient and selective transformations, allowing chemists to access complex derivatives with high precision. This has opened up new avenues for drug discovery and material innovation.

The pharmacological potential of 3-Methoxy-2-(prop-2-yn-1-yloxy)benzaldehyde has been investigated through various computational and experimental approaches. Studies have suggested that derivatives of this compound may exhibit inhibitory effects on certain enzymes and receptors implicated in metabolic disorders and inflammatory diseases. While further research is needed to fully elucidate its therapeutic profile, these findings highlight its promise as a lead compound for future drug development.

In conclusion, 3-Methoxy-2-(prop-2-yn-1-yloxy)benzaldehyde (CAS No. 58758-45-5) represents a fascinating molecule with broad applications across multiple scientific disciplines. Its unique structural features, coupled with its reactivity, make it an indispensable tool for synthetic chemists and pharmacologists alike. As research continues to uncover new ways to harness its potential, this compound is poised to play a significant role in advancing both medicinal chemistry and materials science.

• 67827-54-7(Benzaldehyde,2,4,5-triethoxy-)
• 189831-71-8(Benzaldehyde,2-ethoxy-3,4-dimethoxy-)
• 403507-41-5(Benzaldehyde, 2-ethoxy-5-(2-propynyloxy)- (9CI))
• 250638-02-9(Benzaldehyde, 2-ethoxy-4,5-dimethoxy- (9CI))
• 100256-89-1(3-Ethoxy-2-propoxybenzaldehyde)
• 66799-97-1(2-Ethoxy-3-methoxybenzaldehyde)
• 224317-65-1(5-Methoxy-2-(prop-2-yn-1-yloxy)benzaldehyde)
• 797762-96-0(Benzaldehyde,3,5-diethoxy-2-hydroxy-4-methyl-)
• 75792-34-6(3-ethoxy-2-methoxybenzaldehyde)
• 182067-51-2(2-Ethoxy-3-hydroxybenzaldehyde)