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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid esters
• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acid derivatives Carboxylic acid esters

Ethyl Acetate-¹³C (CAS No. 58735-82-3): An Overview of Its Properties, Applications, and Recent Research Advances

Ethyl Acetate-¹³C (CAS No. 58735-82-3) is a labeled compound that has gained significant attention in various scientific and industrial applications due to its unique isotopic properties. This compound is a derivative of ethyl acetate, where one or more of the carbon atoms are replaced with the stable isotope ¹³C. The presence of ¹³C provides enhanced detectability and traceability, making it invaluable in fields such as metabolomics, pharmacokinetics, and environmental analysis.

The chemical structure of Ethyl Acetate-¹³C is identical to that of its unlabeled counterpart, ethyl acetate (CH₃COOCH₂CH₃). However, the substitution of ¹³C for ¹²C results in a slight increase in molecular weight and a distinct nuclear magnetic resonance (NMR) signal. These properties make Ethyl Acetate-¹³C an ideal candidate for use in NMR spectroscopy and mass spectrometry (MS) studies.

In metabolomics, Ethyl Acetate-¹³C is employed as an internal standard to ensure the accuracy and precision of metabolite quantification. The stable isotope labeling allows researchers to distinguish between endogenous and exogenous metabolites, providing a clearer understanding of metabolic pathways. Recent studies have utilized Ethyl Acetate-¹³C to investigate the metabolism of fatty acids and their derivatives in various biological systems, including human cells and animal models.

In the field of pharmacokinetics, Ethyl Acetate-¹³C is used to trace the absorption, distribution, metabolism, and excretion (ADME) of drugs. By incorporating ¹³C-labeled ethyl acetate into drug formulations, researchers can monitor the fate of the drug in vivo with high sensitivity and specificity. This approach has been particularly useful in optimizing drug dosing regimens and assessing drug-drug interactions.

Ethyl Acetate-¹³C also finds applications in environmental analysis. It can be used as a tracer to study the fate and transport of organic pollutants in environmental matrices such as soil, water, and air. The stable isotope labeling allows for the differentiation between natural and anthropogenic sources of pollutants, providing valuable insights into environmental contamination and remediation strategies.

The synthesis of Ethyl Acetate-¹³C typically involves the reaction of acetic acid or acetyl chloride with ethanol enriched with ¹³C-labeled acetic acid or ethanol. The resulting product is then purified using techniques such as distillation or chromatography to ensure high purity and isotopic enrichment. Recent advancements in synthetic methods have led to more efficient and cost-effective production processes, making Ethyl Acetate-¹³C more accessible for research and industrial applications.

In addition to its analytical applications, Ethyl Acetate-¹³C has potential uses in chemical synthesis. The labeled compound can serve as a starting material or reagent in synthetic routes where isotopic labeling is desired. For example, it can be used to synthesize labeled derivatives for use in pharmaceutical development or as tracers in biochemical assays.

The safety profile of Ethyl Acetate-_{13C is similar to that of its unlabeled counterpart. It is generally considered safe for laboratory use when proper handling and storage protocols are followed. However, it is important to note that like any chemical compound, it should be handled with care to avoid inhalation, ingestion, or skin contact.}

In conclusion, Ethyl Acetate-13C (CAS No. 58735-82-3) is a versatile labeled compound with a wide range of applications in scientific research and industrial processes. Its unique isotopic properties make it an essential tool for metabolomics, pharmacokinetics, environmental analysis, and chemical synthesis. Ongoing research continues to expand its utility, highlighting its importance in advancing our understanding of complex biological systems and environmental processes.

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