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• 3. An investigation of surface properties, local elastic modulus and interaction with simulated pulmonary surfactant of surface modified inhalable voriconazole dry powders using atomic force microscopy
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Comprehensive Analysis of Ethyl-3-(p-chlorophenyl)-4-pyrazole carboxylate (CAS No. 58582-98-2): Properties, Applications, and Industry Trends

Ethyl-3-(p-chlorophenyl)-4-pyrazole carboxylate (CAS No. 58582-98-2) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This pyrazole derivative features a p-chlorophenyl group and an ethyl carboxylate moiety, making it a versatile intermediate for synthesizing bioactive molecules. Its molecular structure (C₁₂H₁₁ClN₂O₂) and unique functional groups contribute to its wide applicability in modern chemistry.

Recent studies highlight the growing demand for heterocyclic compounds like ethyl-3-(p-chlorophenyl)-4-pyrazole carboxylate due to their role in developing novel crop protection agents and pharmaceutical intermediates. Industry reports indicate a 12% annual growth in the pyrazole-based chemicals market, driven by the need for sustainable agrochemicals and targeted drug delivery systems. Researchers are particularly interested in its potential as a building block for non-steroidal anti-inflammatory drugs (NSAIDs) and anticancer agents.

The synthesis of CAS 58582-98-2 typically involves condensation reactions between hydrazine derivatives and β-keto esters, followed by chlorophenyl incorporation. Advanced purification techniques such as column chromatography ensure high purity (>98%), which is critical for pharmaceutical applications. Analytical characterization via HPLC, NMR spectroscopy, and mass spectrometry confirms its structural integrity, addressing quality concerns raised in recent FDA guidance for synthetic intermediates.

Environmental considerations have propelled research into green chemistry approaches for producing ethyl-3-(p-chlorophenyl)-4-pyrazole carboxylate. A 2023 study demonstrated a 40% reduction in solvent waste using microwave-assisted synthesis, aligning with EPA Green Chemistry Principles. This resonates with current searches for "sustainable chemical synthesis" and "eco-friendly intermediates" across scientific databases.

In agrochemical applications, CAS 58582-98-2 serves as a precursor for next-generation pesticides with lower environmental persistence. Its chlorophenyl group enhances target specificity against fungal pathogens while maintaining favorable mammalian toxicity profiles—a key focus in recent "safe pesticide formulation" discussions. Regulatory agencies increasingly favor such compounds under REACH and OECD guidelines for chemical safety.

The pharmaceutical industry leverages ethyl-3-(p-chlorophenyl)-4-pyrazole carboxylate to develop COX-2 inhibitors with improved gastrointestinal tolerance. Patent analyses reveal a 28% increase in filings involving this pyrazole core structure since 2020, particularly for chronic pain management therapies. These trends correlate with rising Google searches for "new arthritis drug mechanisms" and "non-opioid analgesics."

Quality control standards for 58582-98-2 adhere to ICH Q7 guidelines, with stringent limits on residual solvents and heavy metals. Analytical method development using UHPLC-MS/MS has become crucial, as evidenced by recent publications addressing "impurity profiling" in pharmaceutical intermediates. This aligns with industry demands for "high-purity synthetic building blocks" in drug discovery pipelines.

Emerging research explores the compound's potential in material science, particularly as a ligand for luminescent metal complexes used in OLED technologies. A 2024 Journal of Materials Chemistry paper highlighted its utility in creating blue-emitting materials, tapping into the booming "display technology innovations" market. Such interdisciplinary applications demonstrate the compound's versatility beyond traditional domains.

Storage and handling recommendations for ethyl-3-(p-chlorophenyl)-4-pyrazole carboxylate emphasize protection from moisture and oxidation. Industry best practices suggest nitrogen-purged containers at controlled temperatures (2-8°C), reflecting updated ISO storage standards for sensitive organics. These protocols address common laboratory queries about "chemical stability optimization" in research forums.

Market analysts project steady growth for CAS 58582-98-2 suppliers, with Asia-Pacific emerging as the dominant production hub. The compound's cost-effective synthesis and regulatory compliance position it favorably against alternative heterocyclic intermediates. This economic perspective responds to frequent searches for "bulk pharmaceutical raw materials" and "agrochemical sourcing trends" across B2B platforms.

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