• 1. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 2. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 3. Fe3O4/Au/Fe3O4 nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation
  Feng Shi,Kunping Yan,Mingli Peng,Xiao Cheng,Yanling Luo,Xuemei Chen,V. A. L. Roy,Zuankai Wang Nanoscale, 2012,4, 747-751
• 4. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
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• 5. Examination of deposit in commercial diluted phosphoric acid
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alkyl aryl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Alkyl aryl ethers

Comprehensive Guide to 2-(Pyridin-4-yloxy)acetic acid (CAS No. 58530-47-5): Properties, Applications, and Industry Insights

2-(Pyridin-4-yloxy)acetic acid (CAS No. 58530-47-5) is a specialized organic compound gaining attention in pharmaceutical and agrochemical research due to its unique molecular structure. This pyridine derivative features a carboxylic acid functional group linked via an ether bond to the 4-position of the pyridine ring, making it a versatile building block in synthetic chemistry. Recent studies highlight its potential as a key intermediate in developing biologically active molecules, particularly in the design of enzyme inhibitors and crop protection agents.

The compound's physicochemical properties contribute to its growing popularity. With a molecular formula of C₇H₇NO₃ and molecular weight of 153.14 g/mol, 2-(Pyridin-4-yloxy)acetic acid typically appears as a white to off-white crystalline powder. Its solubility profile—soluble in polar organic solvents like methanol and DMSO but limited in water—makes it particularly useful in organic synthesis. Researchers frequently inquire about its pKa value (approximately 3.5 for the carboxylic acid group) and thermal stability (decomposition above 200°C), which are critical parameters for reaction optimization.

In pharmaceutical applications, 58530-47-5 serves as a precursor for drug discovery projects targeting inflammatory pathways. The compound's pyridine-oxygen linkage mimics structural motifs found in several FDA-approved drugs, sparking interest in its structure-activity relationships. Recent patent filings reveal its incorporation into kinase inhibitor scaffolds, with particular relevance to cancer research and metabolic disorder therapeutics. These developments align with current trends in personalized medicine and targeted therapy approaches dominating biomedical discussions.

The agrochemical sector utilizes 2-(Pyridin-4-yloxy)acetic acid in developing next-generation herbicides and plant growth regulators. Its structural similarity to auxin-like compounds enables modulation of plant physiological processes, addressing the industry's demand for eco-friendly crop solutions. With increasing focus on sustainable agriculture, researchers are exploring its potential in biodegradable formulations that minimize environmental persistence—a hot topic in regulatory circles and consumer-conscious markets.

From a synthetic chemistry perspective, CAS 58530-47-5 offers multiple derivatization opportunities. The carboxylic acid group permits amide coupling or esterification reactions, while the pyridine nitrogen allows for quaternization or coordination chemistry applications. These characteristics make it valuable for creating molecular libraries in combinatorial chemistry—a technique experiencing renewed interest with the rise of AI-assisted drug design platforms. Laboratories frequently search for optimized synthetic protocols involving this compound, particularly those emphasizing atom economy and green chemistry principles.

Quality control of 2-(Pyridin-4-yloxy)acetic acid requires stringent analytical methods. HPLC with UV detection (typically at 254 nm) remains the gold standard for purity assessment, with most commercial samples guaranteeing ≥95% purity. Advanced users often inquire about chiral separation techniques, as the compound's potential stereospecific bioactivity becomes increasingly relevant. Mass spectrometry and NMR characterization (showing distinctive peaks at δ 8.5 ppm for pyridine protons) are equally crucial for structural confirmation—topics frequently discussed in analytical chemistry forums.

Market trends indicate rising demand for 58530-47-5 among contract research organizations and academic laboratories. Suppliers report increased inquiries about bulk quantities and custom synthesis options, reflecting its expanding application scope. The compound's supply chain stability and regulatory compliance status (not classified under hazardous categories) make it attractive for global research initiatives, especially those aligned with United Nations Sustainable Development Goals for responsible innovation.

Future research directions for 2-(Pyridin-4-yloxy)acetic acid may explore its nanomaterial functionalization potential or bioconjugation capabilities for diagnostic applications. The scientific community shows growing interest in its computational modeling parameters—a reflection of the broader shift toward in silico screening methods. As interdisciplinary research expands, this compound's role in bridging chemical biology and materials science continues to evolve, positioning it as a molecule to watch in coming years.

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• 86235-60-1(2-(Isoquinolin-7-yloxy)acetic acid)
• 86649-57-2((Pyridin-3-yloxy)-acetic acid)
• 163348-43-4(Acetaldehyde,2-(3-pyridinyloxy)-)
• 86450-37-5(4-(2-methoxyethoxy)-Pyridine)
• 471894-98-1(2-(3-pyridyloxy)acetic acid;hydrochloride)
• 18342-98-8(Ethyl 2-(pyridin-3-yloxy)acetate)
• 163348-44-5(Acetaldehyde,2-(4-pyridinyloxy)-)
• 86450-38-6(2-(4-pyridinyloxy)-Ethanol)
• 80278-25-7(2-(isoquinolin-5-yloxy)acetic acid)