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• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides 3',5'-cyclic purine nucleotides
• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Cyclic purine nucleotides 3',5'-cyclic purine nucleotides

Comprehensive Overview of Guanosine, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt (9CI) (CAS No. 58329-72-9)

Guanosine, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt (9CI), with the CAS number 58329-72-9, is a chemically modified derivative of guanosine, a fundamental nucleoside in RNA. This compound is of significant interest in biochemical and pharmaceutical research due to its unique structural properties and potential applications in signal transduction and drug development. The modification at the 2'-position with a butanoate group and the presence of a cyclic 3',5'-hydrogen phosphate moiety make it a valuable tool for studying cellular processes.

In recent years, the scientific community has shown growing interest in modified nucleosides like this compound, particularly for their role in second messenger systems. Cyclic nucleotides, such as cyclic GMP (cGMP) and cyclic AMP (cAMP), are well-known for their involvement in intracellular signaling. The structural analog Guanosine, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate may offer new insights into these pathways, especially in the context of neurological disorders and cardiovascular diseases, which are among the most searched health topics online.

The monosodium salt form of this compound enhances its solubility, making it more suitable for experimental applications in aqueous environments. Researchers are particularly interested in its potential as a probe or inhibitor in studies targeting protein kinases and phosphodiesterases, enzymes that play critical roles in cellular regulation. This aligns with the increasing demand for enzyme-targeted therapies, a hot topic in precision medicine and biotech innovation.

From a synthetic chemistry perspective, the introduction of the 2'-butanoate group provides steric and electronic modifications that can influence the compound's binding affinity and stability. Such modifications are often explored in drug design to improve pharmacokinetic properties. Given the rising popularity of computational chemistry and molecular modeling in drug discovery, this compound could serve as a case study for optimizing nucleoside-based therapeutics.

Another area of interest is the compound's potential role in epigenetics and gene expression regulation. Modified nucleosides are known to interact with RNA polymerases and transcription factors, making them relevant to cutting-edge research in cancer biology and stem cell therapy. These topics frequently appear in academic searches and AI-driven queries, reflecting their importance in modern science.

Quality control and analytical characterization of Guanosine, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt are critical for its use in research. Techniques such as HPLC, mass spectrometry, and NMR spectroscopy are commonly employed to verify its purity and structure. Researchers and manufacturers must adhere to stringent standards, as impurities can significantly impact experimental outcomes. This emphasis on quality resonates with the broader scientific community's focus on reproducibility and rigor in research.

In summary, Guanosine, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt (9CI) (CAS 58329-72-9) represents a sophisticated nucleoside derivative with multifaceted applications in biochemistry and medicine. Its relevance to signal transduction, drug development, and molecular biology makes it a compound of enduring interest, particularly in an era where personalized medicine and targeted therapies dominate scientific discourse. As research continues to uncover its full potential, this compound is poised to remain a focal point in both academic and industrial settings.

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