Cas no 58053-83-1 (17.β.-hydroxy Wortmannin)
17.β.-Hydroxy Wortmannin is a biologically active derivative of the natural product Wortmannin, known for its potent and selective inhibition of phosphatidylinositol 3-kinases (PI3Ks). This compound retains the irreversible binding mechanism of its parent molecule, effectively blocking PI3K signaling pathways critical in cellular processes such as proliferation, survival, and metabolism. Its hydroxyl modification enhances solubility and stability, making it a valuable tool for biochemical and pharmacological research. 17.β.-Hydroxy Wortmannin is particularly useful in studying cancer, immunology, and neurodegenerative diseases due to its ability to modulate PI3K-dependent pathways with high specificity. Researchers favor this analog for its improved handling properties while maintaining strong inhibitory activity.
17.β.-hydroxy Wortmannin structure
Product Name:17.β.-hydroxy Wortmannin
CAS No:58053-83-1
MF:C23H26O8
MW:430.447747707367
CID:4457474
PubChem ID:9867340
Update Time:2025-05-28
17.β.-hydroxy Wortmannin Chemical and Physical Properties
Names and Identifiers
-
- 17.β.-hydroxy Wortmannin
- 17β-hydroxy Wortmannin Exclusive
- XLJORQYAOTYVQS-OGCOKEDGSA-N
- 17.beta.-hydroxy Wortmannin
- PI 3-K Inhibitor XI, HWT - CAS 58053-83-1 - Calbiochem
- 3H-Furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6(1H)-dione, 11-(acetyloxy)-6b,7,8,9,9a,10,11,11b-octahydro-9-hydroxy-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9S,9aS,11R,11bR)-
- 17β-hydroxy Wortmannin
- [(1R,3R,5S,6S,9R,18S)-6-hydroxy-18-(methoxymethyl)-1,5-dimethyl-11,16-dioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] acetate
- 17-hydroxy Wortmannin
- 17-hydroxy-wortmannin
- PD021155
- 17-Hydroxywortmannin
- 17
- SCHEMBL8021215
- CS-0090411
- 17beta-Hydroxywortmannin
- BDBM50612802
- 17beta-Hydroxy wortmannin
- 58053-83-1
- HY-126083
- A-Hydroxywortmannin
- CHEMBL273832
-
- Inchi： 1S/C23H26O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-15,25H,5-7,9H2,1-4H3/t12-,13+,14-,15+,22-,23-/m0/s1
- InChI Key： XLJORQYAOTYVQS-OGCOKEDGSA-N
- SMILES： O[C@H]1CC[C@H]2C3C(C4=C5C(=CO4)C(=O)O[C@H](COC)[C@]5(C)C=3[C@@H](C[C@@]21C)OC(C)=O)=O
Computed Properties
- Exact Mass: 430.16276778g/mol
- Monoisotopic Mass: 430.16276778g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 8
- Heavy Atom Count: 31
- Rotatable Bond Count: 4
- Complexity: 879
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 6
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 1.5
- Topological Polar Surface Area: 112?2
17.β.-hydroxy Wortmannin Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci68200-1mg |
17β-hydroxy Wortmannin |
58053-83-1 | 98% | 1mg |
￥1227.00 | 2022-04-26 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci68200-5mg |
17β-hydroxy Wortmannin |
58053-83-1 | 98% | 5mg |
￥5007.00 | 2022-04-26 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci68200-10mg |
17β-hydroxy Wortmannin |
58053-83-1 | 98% | 10mg |
￥8438.00 | 2022-04-26 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci68200-500ug |
17β-hydroxy Wortmannin |
58053-83-1 | 98% | 500ug |
￥696.00 | 2022-04-26 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | W912588-1mg |
17β-hydroxy Wortmannin |
58053-83-1 | 98% | 1mg |
￥1,845.90 | 2022-11-27 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R123878-1mg |
17β-hydroxy Wortmannin,98% |
58053-83-1 | 98% | 1mg |
￥1969 | 2022-11-27 | |
| Cooke Chemical | M8040747-1mg |
17β-hydroxyWortmannin |
58053-83-1 | 98% | 1mg |
RMB 1640.80 | 2025-02-21 | |
| SHENG KE LU SI SHENG WU JI SHU | sc-358740-500μg |
17β-hydroxy Wortmannin, |
58053-83-1 | 500μg |
￥692.00 | 2023-09-05 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-358740A-1mg |
17β-hydroxy Wortmannin, |
58053-83-1 | 1mg |
￥1324.00 | 2023-09-05 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-358740-500 μg |
17β-hydroxy Wortmannin, |
58053-83-1 | 500μg |
￥692.00 | 2023-07-11 |
17.β.-hydroxy Wortmannin Related Literature
-
Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
-
Chen Long,Ying Dai,Jianwei Li,Hao Jin Nanoscale, 2020,12, 21124-21130
-
Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
-
Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
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