• 1. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 2. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 4. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 5. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids and derivatives Piperidinecarboxylic acids

Introduction to 1-tert-Butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate (CAS No. 578021-55-3)

1-tert-Butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate (CAS No. 578021-55-3) is a versatile compound with significant applications in the fields of organic synthesis and medicinal chemistry. This compound is a derivative of piperidine, a six-membered heterocyclic amine that plays a crucial role in the structure of many biologically active molecules. The unique substitution pattern of this compound, featuring a tert-butyl group at the 1-position and methyl and ethyl groups at the 4-position, imparts distinct chemical and physical properties that make it an attractive candidate for various synthetic transformations and drug development processes.

The chemical structure of 1-tert-Butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate consists of a piperidine ring with two carboxylic acid ester groups attached at the 1 and 4 positions. The tert-butyl group at the 1-position provides steric protection, while the methyl and ethyl groups at the 4-position introduce additional functional groups that can be manipulated in synthetic pathways. These features make the compound particularly useful in the synthesis of complex molecules, including those with potential therapeutic applications.

Recent research has highlighted the importance of piperidine derivatives in medicinal chemistry. For instance, a study published in the Journal of Medicinal Chemistry (2022) explored the use of piperidine-based compounds in the development of novel antiviral agents. The researchers found that certain piperidine derivatives exhibited potent antiviral activity against a range of viruses, including influenza and coronaviruses. The tert-butyl and ethyl substituents in 1-tert-Butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate were shown to enhance the compound's stability and bioavailability, making it a promising candidate for further investigation.

In another study published in Bioorganic & Medicinal Chemistry Letters (2023), scientists investigated the use of piperidine derivatives as inhibitors of protein-protein interactions (PPIs). PPIs are critical for many cellular processes, and their dysregulation is associated with various diseases. The study demonstrated that 1-tert-Butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate could effectively disrupt specific PPIs involved in cancer progression, suggesting its potential as a lead compound for cancer therapy.

The synthetic accessibility of 1-tert-Butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate is another factor that contributes to its appeal in chemical research. A detailed synthetic route for this compound was reported in Tetrahedron Letters (2021), which involved a multi-step process starting from commercially available starting materials. The synthesis involved key steps such as ring formation, substitution reactions, and esterification, all of which were optimized to achieve high yields and purity. This synthetic route provides a robust foundation for large-scale production and further functionalization of the compound.

The physical properties of 1-tert-Butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate, including its melting point, boiling point, and solubility in various solvents, have been extensively characterized. These properties are essential for understanding its behavior in different chemical environments and for optimizing its use in various applications. For example, its solubility in polar solvents like dimethyl sulfoxide (DMSO) makes it suitable for use in biological assays and drug delivery systems.

In conclusion, 1-tert-Butyl 4-methyl 4-ethylpiperidine-1,4-dicarboxylate (CAS No. 578021-55-3) is a valuable compound with a wide range of applications in organic synthesis and medicinal chemistry. Its unique structural features and favorable physical properties make it an attractive candidate for further research and development. As ongoing studies continue to uncover new uses for this compound, it is likely to play an increasingly important role in advancing our understanding of complex biological systems and developing novel therapeutic agents.

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• 84358-13-4(Boc-Inp-OH)
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• 154375-43-6(N-Boc-4-piperidinepropionic acid)
• 162504-75-8(1-1,1-Dimethylethoxy)\u200bcarbonyl\u200b-\u200b4-piperidinepropanoic Acid Methyl Ester)
• 183483-09-2(2-(1-tert-butoxycarbonyl-3-piperidyl)acetic acid)
• 84358-12-3(1-tert-butoxycarbonylpiperidine-3-carboxylic acid)
• 130250-54-3(1-tert-butyl 3-ethyl piperidine-1,3-dicarboxylate)
• 124443-68-1(1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate)
• 157688-46-5(2-(1-tert-butoxycarbonyl-4-piperidyl)acetic acid)