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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes 2,5-disubstituted thiophenes

Comprehensive Guide to 2-Thiophenecarboxaldehyde, 5-amino- (CAS No. 57500-50-2): Properties, Applications, and Industry Insights

2-Thiophenecarboxaldehyde, 5-amino- (CAS No. 57500-50-2) is a specialized organic compound featuring a thiophene ring substituted with an amino group and a formyl group. This unique structure makes it a valuable intermediate in pharmaceuticals, agrochemicals, and material science. The compound's molecular formula C5H5NOS and molecular weight 127.16 g/mol highlight its compact yet reactive nature, ideal for synthetic modifications. Researchers frequently search for "5-amino-2-thiophenecarboxaldehyde synthesis" or "CAS 57500-50-2 applications," reflecting its industrial relevance.

In the pharmaceutical sector, 2-Thiophenecarboxaldehyde, 5-amino- serves as a precursor for heterocyclic drug development, particularly in kinase inhibitors and antimicrobial agents. Its thiophene backbone mimics bioactive motifs found in natural products, enhancing drug-target interactions. Recent studies explore its role in "green chemistry" and "catalysis," aligning with the global push for sustainable synthesis methods. Users often inquire about "biodegradability of 5-amino-2-thiophenecarboxaldehyde" or "solubility in polar solvents," underscoring environmental and practical concerns.

The compound's spectral data (e.g., IR peaks at 1660 cm?1 for C=O stretch and NMR shifts at δ 9.8 ppm for aldehyde proton) are critical for quality control. Analytical queries like "HPLC methods for CAS 57500-50-2" or "stability under UV light" dominate academic discussions. Additionally, its use in OLED materials and conductive polymers attracts attention from the electronics industry, where searches for "thiophene derivatives in flexible electronics" are trending.

Regulatory compliance is another hot topic. While 2-Thiophenecarboxaldehyde, 5-amino- is not classified as hazardous under major frameworks like REACH, proper handling guidelines are often sought using terms like "CAS 57500-50-2 SDS." The compound's melting point (80–82°C) and storage conditions (2–8°C under inert atmosphere) are frequently referenced in technical datasheets.

Emerging applications include metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), where its bifunctional groups enable precise structural tuning. Searches for "5-amino-2-thiophenecarboxaldehyde in nanotechnology" reflect this interdisciplinary interest. Furthermore, its role in flavor and fragrance formulations—owing to its mild, sulfurous aroma—is gaining traction in niche markets.

In summary, 2-Thiophenecarboxaldehyde, 5-amino- (CAS No. 57500-50-2) bridges multiple scientific domains, from life sciences to advanced materials. Its versatility and compatibility with modern flow chemistry techniques position it as a compound of enduring significance, answering contemporary queries like "scalable production of thiophene aldehydes" and "cross-coupling reactions with 5-amino-2-thiophenecarboxaldehyde."

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