• 1. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 2. Enantiocontrolled construction of sistodiolynne, an unusual polyketide from the wood-decay fungus Sistrema raduloides
  Chem. Commun., 1997, 767-768
• 3. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 4. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 5. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alkyl aryl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Alkyl aryl ethers

2,5-Dichloro-4-methoxypyrimidine: A Comprehensive Overview

The compound 2,5-Dichloro-4-methoxypyrimidine, also known by its CAS number 5750-74-3, is a heterocyclic aromatic compound with significant applications in various fields. This compound belongs to the pyrimidine family, which is a six-membered ring consisting of four carbon atoms and two nitrogen atoms at positions 1 and 3. The substitution pattern of this compound includes two chlorine atoms at positions 2 and 5, and a methoxy group (-OCH3) at position 4. These substituents play a crucial role in determining the chemical properties and reactivity of the molecule.

Recent studies have highlighted the potential of 2,5-Dichloro-4-methoxypyrimidine in the field of medicinal chemistry. Researchers have explored its role as a building block for synthesizing bioactive compounds with potential therapeutic applications. For instance, derivatives of this compound have shown promising results in anti-cancer studies, particularly in targeting specific enzymes involved in cancer cell proliferation. The methoxy group at position 4 contributes to the compound's solubility and bioavailability, making it an attractive candidate for drug development.

In addition to its medicinal applications, 2,5-Dichloro-4-methoxypyrimidine has also found utility in agrochemicals. Its ability to inhibit certain enzymes related to plant growth regulation has led to its investigation as a potential herbicide or fungicide. Recent advancements in green chemistry have further enhanced the synthesis methods of this compound, making it more environmentally friendly and cost-effective.

The synthesis of 2,5-Dichloro-4-methoxypyrimidine typically involves multi-step reactions, often starting from readily available starting materials such as pyrimidine derivatives or chlorinated intermediates. Modern synthetic strategies have focused on improving yield and purity through optimized reaction conditions and catalysts. For example, microwave-assisted synthesis has been employed to accelerate reaction rates and reduce reaction times.

From a structural perspective, the presence of electron-withdrawing groups like chlorine atoms at positions 2 and 5 significantly influences the electronic properties of the pyrimidine ring. This makes the compound highly reactive towards nucleophilic substitution and electrophilic aromatic substitution reactions. The methoxy group at position 4 introduces electron-donating effects through resonance, which can modulate the reactivity of the molecule depending on the reaction conditions.

Recent research has also delved into the photochemical properties of 2,5-Dichloro-4-methoxypyrimidine. Studies have shown that this compound exhibits fluorescence under UV light due to its conjugated system. This property has opened up new avenues for its application in sensors and optoelectronic devices. Furthermore, its stability under various environmental conditions makes it suitable for long-term applications.

In conclusion, 2,5-Dichloro-4-methoxypyrimidine, with its unique structural features and versatile reactivity, continues to be a focal point in both academic and industrial research. Its potential applications span across medicine, agriculture, and materials science, making it a valuable compound for future innovations.

• 5750-77-6(5-Chloro-4-methoxy-2-Pyrimidinamine)
• 358978-09-3(2,5-Dichloro-4-(4-methoxyphenoxy)pyrimidine)
• 123551-49-5(5-Chloro-2,4-dimethoxypyrimidine)
• 22536-63-6(2-Chloro-4-methoxypyrimidine)
• 114969-94-7(5-Chloro-4-methoxypyrimidine)
• 1351762-13-4(2,5-Dichloro-4-isopropoxypyrimidine)
• 76661-10-4(2,5-dichloro-4-phenoxypyrimidine)
• 1823893-30-6(2,5-Dichloro-4-cyclopropoxypyrimidine)
• 188559-26-4(Pyrimidine, 2,5-dichloro-4-(2-propenyloxy)-)
• 1351762-11-2(2,5-dichloro-4-ethoxyPyrimidine)