Cas no 57260-71-6 (N-Boc-piperazine)

N-Boc-piperazine is a protected derivative of piperazine, featuring a tert-butoxycarbonyl (Boc) group that enhances stability and selectivity in synthetic applications. This compound serves as a versatile intermediate in organic synthesis, particularly in peptide coupling and pharmaceutical manufacturing, where its Boc group facilitates controlled deprotection under mild acidic conditions. Its high purity and consistent reactivity make it valuable for constructing complex molecular frameworks, including active pharmaceutical ingredients (APIs) and heterocyclic compounds. N-Boc-piperazine is widely utilized due to its compatibility with a range of reagents and solvents, ensuring efficient incorporation into multi-step synthetic routes while minimizing side reactions.

N-Boc-piperazine structure

Product Name:N-Boc-piperazine

CAS No:57260-71-6

MF:C₉H₁₈N₂O₂

MW:186.251422405243

MDL:MFCD00075265

CID:57100

PubChem ID:24849328

Update Time:2025-11-11

N-Boc-piperazine Chemical and Physical Properties

Names and Identifiers

- N-Boc-Piperazine
- tert-butyl 1-piperazinecarboxylate
- 1-(tert-Butoxycarbonyl)piperazine~tert-Butyl 1-piperazinecarboxylate
- tert-Butyl tetrahydropyrazine-1(2H)-carboxylate
- 1-N-Boc-Piperazine
- Tert-butyl-piperazine carboxylate
- PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- 1-Boc-piperazine
- 1-(tert-Butoxycarbonyl)piperazine
- tert-Butyl piperazine-1-carboxylate
- 2,5-Dibromo-3-methylpyridine
- 1,1-Dimethylethyl 1-piperazinecarboxylate
- 1-Boc piperzine
- BOC-PAZ
- BOC-PIPERAZINE
- PIBOC
- RARECHEM AR PA 0026
- t-Butyl 1-piperazincarboxylate
- tert-butyl l-piperazinecarboxylate
- tert-butyl piperazine-1-carboxylate(SALTDATA: FREE)
- N-t-Butoxycarbonylpiperazine
- n-(tert-butoxycarbonyl)piperazine
- 1-piperazinecarboxylic acid, 1,1-dimethylethyl ester
- N-tert-butoxycarbonylpiperazine
- piperazine, n1-boc protected
- 1-Boc-piperazine acetic acid
- tert-butyloxycarbony
- 1-Boc-piperazine,99%
- 1-(tert-Butyloxycarbonyl)piperazine
- 1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
- 1-Piperazinecarboxylic Acid tert-Butyl Este
- N-(tert-Butoxycarbonyl)piperazine 98%
- tert-Butyl 2-piperazinecarboxylate
- N-(T-BUTYLOXYCARBONYL)-PIPERAZINE
- n-(tert-butyloxycarbonyl)-piperazine
- 1-Boc-piperazine, >=98.0% (GC)
- 4-(t-butoxycarbonyl)piperazine
- 1- (tert-butoxycarbonyl)piperazine
- 1,1-dimethylethyl 1-piperazine carboxylate
- tert-butyl piperazinecarboxylate
- 1-N-t-butoxycarbonylpiperazine
- 1-boc piperazine
- piperazine 1-carboxylic acid tert butyl ester
- 1-tert-butoxycarbonylpiperazine
- 1-(t-Butoxycarbonyl)piperazine
- 1 -t-butoxycarbonyl piperazine
- 4-(tert-butoxycarbonyl)piperazine
- 1-tert.-butoxycarbonylpiperazine
- tert butyl piperazinecarboxylate
- 1-(t-butoxycarbonyl )piperazine
- EC 611-489-0
- tert.butyl-piperazine-1-carboxylate
- 1-t-butoxycarbonyl piperazine
- tert.butyl piperazine-1-carboxylate
- Q-102957
- SCHEMBL8286
- tert-butylpiperazin-1-carboxylate
- N-(tert.butyloxycarbonyl)-piperazine
- 1-tert-butyloxycarbonylpiperazine
- J-650366
- (1,1-dimethylethoxy)carbonylpiperazine
- piperazine-1-carboxylic acid tert butyl ester
- t-butyl-1-piperazine-carboxylate
- MFCD08705174
- 1-tert-butyloxycarbonylpiperazin
- 4-tert-butoxycarbonylpiperazine
- 1-(1,1-dimethylethoxycarbonyl)piperazine
- 1-Boc-piperazine, 97%
- tert-butylpiperazinecarboxylate
- 1-tert-butyl piperazinecarboxylate
- PS-3951
- AM20080327
- tert-butyl-1-piperazine carboxylate
- tert.-butyl piperazine-1-carboxylate
- N-(t-butoxycarbonyl)piperazine
- EN300-25694
- 1-tert-butoxycarbonyl piperazine
- DTXSID30205884
- tert-butyl 1 piperazinecarboxylate
- tert-butyl piperizine-1-carboxylate
- tert-butyl-piperazine-1-carboxylate
- FT-0688673
- tert-butylpiperazine-1-carboxylate
- tertbutyl-1-piperazinecarboxylate
- 1-(tertiary butoxycarbonyl)piperazine
- tert. butyl piperazine-1-carboxylate
- 1,1-dimethylethyl piperazinecarboxylate
- tert-butyl piperazine-1 carboxylate
- tert-butyl piperazine-1carboxylate
- tert-butyl 1-piperazine-carboxylate
- LBC2X3S28C
- t-butylpiperazine-1-carboxylate
- piperazine-1-carboxylic acid t-butyl ester
- 1-t-butoxycarbonylpiperazine
- 1-tert-Butoxycarbonyl-piperazine
- N-Boc piperazine
- UNII-LBC2X3S28C
- N-tert-butoxycarbonyl piperazine
- 1-(1,1-dimethyl-ethoxycarbonyl)piperazine
- 1-Boc-piperazine-2,2,3,3,5,5,6,6-d8
- 1-tertbutoxycarbonylpiperazine
- tert-butyl 1-piperazinecaboxylate
- t-butylpiperazin-1-carboxylate
- t-butyl-1-piperazinecarboxylate
- STR03894
- tert-Butyl 1-piperazinecarboxylate #
- 1-(Boc)piperazine
- 1-Boc piperizine
- t-butyl piperazine carboxylate
- 1-piperazine carboxylic acid tert-butyl ester
- 1-Bocpiperazine
- T-butylpiperazine carboxylate
- 1-[1,1-dimethylethoxycarbonyl]piperazine
- tert-butyl piperazin-1-carboxylate
- 1-(tert-butoxycarbonyl)-piperizine
- t-butyl piperazine-1-carboxylate
- 1(tert-butoxycarbonyl)piperazine
- 1-tert-butyl 1-piperazinecarboxylate
- tert-butoxycarbonylpiperazine
- Tert-butyl-1-piperazine-carboxylate
- piperazine-1-carboxylic acid-tert-butyl ester
- n-tert-butoxycarbonyl-piperazin
- 4-N-boc-piperazine
- piperazine carboxylic acid tert -butyl ester
- tert-butyl-1-piperazinecarboxylate
- t-butyl piperazine-l-carboxylate
- N-terbutyloxycarbonyl-piperazine
- BB 0258987
- tert-butyloxycarbonylpiperazine
- HY-30105
- tert.butyl 1-piperazine carboxylate
- AB02865
- mono-boc piperizine
- 1,1-dimethylethyl piperazine-1-carboxylate
- tert-butoxycarbonyl piperazine
- piperazine-1-carboxylic acid t-butylester
- piperazine-l-carboxylic acid tert-butyl ester
- FT-0648906
- 1-t-butyloxycarbonylpiperazine
- piperazine carboxylic acid tert-butyl ester
- piperazine-carboxylic acid tert-butyl ester
- tertbutyl 1-piperazinecarboxylate
- tert-butyl-1-piperzinecarboxylate
- 1-boc-piperazine;1-boc-piperazine;N-BOC-Piperazine
- piperazine-N-carboxylic acid tert-butyl ester
- n-boc -piperazine
- N-tert.butoxycarbonyl-piperazine
- piperazine-4-carboxylic acid tert-butyl ester
- N-t-butoxycarbonyl piperazine
- t-butyl piperazine-n-carboxylate
- 1,1-dimethylethyl 1-piperazine-carboxylate
- t-butyl 1-piperazinecarboxylate
- t-butoxycarbonyl-piperazine
- 1-piperazinecarboxylic acid tert-butyl ester
- piperazin-1-carboxylic acid t-butyl ester
- N-tert-butyloxycarbonyl-piperazine
- FT-0601105
- N-(tert-butoxycarbonyl)-piperazine
- N-Bocpiperazine
- 1-BOC-piperizine
- CS-B0963
- MFCD00075265
- piperazine-1-carboxylic acid tert.butyl ester
- Olaparib Impurity 7
- 1-tert-butyloxycarbonyl-piperazine
- piperazin-1-carboxylic acid tert-butyl ester
- tert.-butyl-piperazine-1-carboxylate
- 1-(1,1-dimethylethyloxycarbonyl)piperazine
- n-tert-butoxycarbonyl-piperazine
- tert-butyl 1-piperazine carboxylate
- t-butyloxycarbonyl piperazine
- 1-(tert-butoxycarbonyl)-piperazine
- F1652-2152
- 4-Boc-piperazine
- piperazine 1-carboxylic acid tert-butyl ester
- BP-12039
- t-butyl piperazinecarboxylate
- 1-(1,1-dimethylethoxycarbonyl) piperazine
- 1-t-butoxycarbonyl-piperazine
- AC-1098
- t-Butyl 1-piperaziencarboxylate
- 1-tert.-butyloxycarbonyl-piperazine
- BCP04907
- (tert-butoxycarbonyl)piperazine
- 1-piperazinecarboxylic acid t-butyl ester
- t-butoxycarbonylpiperazine
- N-Boc piperizine
- piperazine-1-carboxylic acid, tert-butyl ester
- SY320985
- N-(tertbutoxycarbonyl)piperazine
- 1-ter-butoxycarbonylpiperazine
- 1-(t-butoxycarbonyl) piperazine
- t-butyl-1-piperazine carboxylate
- n-tert-butyloxycarbonylpiperazine
- 1-tert-butoxycarbonyl-piperazin
- N-(tert-butoxy carbonyl)piperazine
- AKOS000365379
- 1-(1,1-dimethylethoxycarbonyl)-piperazine
- piperazin-1-yl carboxylic acid tert-butyl ester
- Mono-BOC-piperazine
- Z57318234
- t-butyl 1-piperazine carboxylate
- N-(tert-butyloxycarbonyl)piperazine
- SB11222
- tert.butyloxycarbonyl-piperazine
- 57260-71-6
- 1-tertbutyloxycarbonylpiperazine
- BOC piperazine
- InChI=1/C9H18N2O2/c1-9(2,3)13-8(12)11-6-4-10-5-7-11/h10H,4-7H2,1-3H
- Boc piperizine
- B2415
- t-butylpiperazinecarboxylate
- N-tert-butyloxycarbonyl piperazine
- tert butoxy carbonyl piperazine
- A8166
- N-Boc-piperazine
- MDL： MFCD00075265
- Inchi： 1S/C9H18N2O2/c1-9(2,3)13-8(12)11-6-4-10-5-7-11/h10H,4-7H2,1-3H3
- InChI Key： CWXPZXBSDSIRCS-UHFFFAOYSA-N
- SMILES： O(C(N1CCNCC1)=O)C(C)(C)C
- BRN： 879985

Computed Properties

Exact Mass: 186.13700
Monoisotopic Mass: 186.137
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Heavy Atom Count: 13
Rotatable Bond Count: 2
Complexity: 181
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: nothing
XLogP3: 0.5
Topological Polar Surface Area: 41.6

Experimental Properties

Color/Form: Crystalline powder
Density: 1.0300
Melting Point: 43-47?°C (lit.)
Boiling Point: 98-100
Flash Point: Degrees Fahrenheit:235.4°F
Degrees Celsius:113°C
Solubility: Soluble in DMSO
Water Partition Coefficient: Soluble in ethyl acetate, methanol and water.
PSA: 41.57000
LogP: 1.09340
Solubility: Insoluble
Sensitiveness: Air Sensitive
pka: 8.45±0.10(Predicted)

N-Boc-piperazine Security Information

Symbol:
Prompt：warning
Signal Word：Warning
Hazard Statement： H315,H319,H335
Warning Statement： P261,P305+P351+P338
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：3
Hazard Category Code： 36/37/38
Safety Instruction： S26
FLUKA BRAND F CODES：3-10-34
Hazardous Material Identification：
Safety Term：S26
Risk Phrases：R36/37/38
HazardClass：IRRITANT
Storage Condition：0-10°C

N-Boc-piperazine Customs Data

HS CODE：2933990090
Customs Data：

China Customs Code:
2933599090

Overview:

2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

Declaration elements:

Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

Summary:

2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-Boc-piperazine Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI XIAN DING Biotechnology Co., Ltd.	B2415-5g	N-Boc-piperazine	57260-71-6	98.0%(GC&T)	5g	￥110.0	2022-05-30
SHANG HAI XIAN DING Biotechnology Co., Ltd.	B2415-25g	N-Boc-piperazine	57260-71-6	98.0%(GC&T)	25g	￥250.0	2022-05-30
SHANG HAI XIAN DING Biotechnology Co., Ltd.	BQ516-100g	N-Boc-piperazine	57260-71-6	99%	100g	￥207.0	2022-05-30
SHANG HAI XIAN DING Biotechnology Co., Ltd.	BQ516-25g	N-Boc-piperazine	57260-71-6	99%	25g	￥89.0	2022-05-30
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Fluorochem	021572-25g	1-Boc-Piperazine	57260-71-6	98%	25g	￡10.00	2022-03-01
Fluorochem	021572-100g	1-Boc-Piperazine	57260-71-6	98%	100g	￡33.00	2022-03-01
Fluorochem	021572-250g	1-Boc-Piperazine	57260-71-6	98%	250g	￡58.00	2022-03-01
Fluorochem	021572-500g	1-Boc-Piperazine	57260-71-6	98%	500g	￡99.00	2022-03-01
SHANG HAI YI EN HUA XUE JI SHU Co., Ltd.	R004877-1g	N-Boc-piperazine	57260-71-6	98%	1g	￥26	2024-05-22

N-Boc-piperazine Production Method

N-Boc-piperazine Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

Audited Supplier

(CAS:57260-71-6)Tert-butyl piperazine-1-carboxylate

Order Number:LE1794;LE1776123

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 11:41

Price ($):discuss personally

Email:[email protected]

Suzhou Senfeida Chemical Co., Ltd

Gold Member

Audited Supplier

(CAS:57260-71-6)tert-Butyl 1-piperazinecarboxylate

Order Number:sfd18544

Stock Status:in Stock

Quantity:200kg

Purity:99.9%

Pricing Information Last Updated:Friday, 19 July 2024 14:38

Price ($):discuss personally

Email:[email protected]

Product Official Link

N-Boc-piperazine Spectrogram

13C NMR

1H NMR

300 MHz

DMSO

N-Boc-piperazine Related Literature

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Damodara N. Kommi,Dinesh Kumar,Asit K. Chakraborti Green Chem. 2013 15 756
2. A systematic exploration of the effects of flexibility and basicity on sigma (σ) receptor binding in a series of substituted diamines

Trent Conroy,Madhura Manohar,Yu Gong,Shane M. Wilkinson,Michael Webster,Brian P. Lieberman,Samuel D. Banister,Tristan A. Reekie,Robert H. Mach,Louis M. Rendina,Michael Kassiou Org. Biomol. Chem. 2016 14 9388
3. Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent NaV1.7 inhibitors

Brian A. Sparling,S. Yi,J. Able,H. Bregman,Erin F. DiMauro,R. S. Foti,H. Gao,A. Guzman-Perez,H. Huang,M. Jarosh,T. Kornecook,J. Ligutti,B. C. Milgram,B. D. Moyer,B. Youngblood,V. L. Yu,M. M. Weiss Med. Chem. Commun. 2017 8 744
4. Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor

Micael Rodrigues Cunha,Rajesh Bhardwaj,Aline Lucie Carrel,Sonja Lindinger,Christoph Romanin,Roberto Parise-Filho,Matthias A. Hediger,Jean-Louis Reymond RSC Med. Chem. 2020 11 1032
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Additional information on N-Boc-piperazine

Introduction to N-Boc-piperazine (CAS No. 57260-71-6)

N-Boc-piperazine, chemically known by its CAS number 57260-71-6, is a significant compound in the field of pharmaceutical and chemical research. This compound, featuring a protected form of piperazine, has garnered considerable attention due to its versatile applications in drug development and synthetic chemistry. The Boc (tert-butoxycarbonyl) group attached to the piperazine ring enhances its stability and reactivity, making it a valuable intermediate in the synthesis of various bioactive molecules.

The utility of N-Boc-piperazine stems from its ability to serve as a precursor in the preparation of more complex molecules. Piperazine derivatives are widely recognized for their role in medicinal chemistry, particularly in the development of drugs targeting neurological and cardiovascular diseases. The Boc protection allows for selective functionalization, enabling chemists to introduce additional modifications at specific positions on the piperazine scaffold.

Recent advancements in the pharmaceutical industry have highlighted the importance of piperazine derivatives in the treatment of various disorders. For instance, studies have demonstrated that compounds incorporating piperazine moieties exhibit potent inhibitory effects on enzymes such as phosphodiesterases and kinases. These enzymes are crucial targets in the management of conditions like hypertension and chronic pain. The introduction of N-Boc-piperazine into synthetic pathways has facilitated the development of novel therapeutic agents with improved pharmacokinetic profiles.

In addition to its pharmaceutical applications, N-Boc-piperazine plays a pivotal role in academic research. Researchers have leveraged this compound to explore new synthetic methodologies and to investigate the structural-activity relationships of piperazine-based drugs. The Boc-protected group provides a reliable handle for further chemical transformations, allowing for the systematic study of molecular modifications. This has led to a deeper understanding of how structural changes influence biological activity, which is essential for rational drug design.

The synthesis of N-Boc-piperazine typically involves the reaction of piperazine with di-tert-butyl dicarbonate (Boc?O) under controlled conditions. This reaction is often catalyzed by acids or bases to ensure high yield and purity. The resulting product is a white crystalline solid that is soluble in organic solvents commonly used in medicinal chemistry laboratories. Its stability under various storage conditions makes it a convenient reagent for both small-scale laboratory experiments and large-scale industrial processes.

One of the most compelling aspects of N-Boc-piperazine is its adaptability in multi-step synthetic routes. Its protected amine group can be selectively deprotected under mild acidic conditions, allowing for subsequent functionalization at other positions on the molecule. This flexibility has been exploited in the synthesis of complex peptidomimetics and heterocyclic compounds. Such molecules are increasingly important in drug discovery due to their ability to mimic natural bioactive peptides while avoiding issues like immunogenicity.

The growing interest in computational chemistry has also contributed to the renewed focus on N-Boc-piperazine. Advanced computational methods enable researchers to predict the behavior of molecules before they are synthesized, saving time and resources. These techniques have been used to model the interactions between piperazine derivatives and biological targets, providing insights into binding affinities and mechanism-of-action. The integration of computational tools with experimental data has enhanced our understanding of how N-Boc-piperazine-based compounds function at a molecular level.

In conclusion, N-Boc-piperazine (CAS No. 57260-71-6) is a cornerstone compound in modern pharmaceutical research. Its unique properties make it an indispensable tool for chemists working on drug discovery and development. As our understanding of disease mechanisms continues to evolve, compounds like this will remain at the forefront of therapeutic innovation. The ongoing exploration of its applications promises to yield new treatments that improve patient outcomes across various medical disciplines.

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