Cas no 57184-25-5 (1-(Cyclopropylmethyl)piperazine)

1-(Cyclopropylmethyl)piperazine is a versatile heterocyclic compound featuring a piperazine core substituted with a cyclopropylmethyl group. This structural motif imparts unique reactivity and stability, making it valuable in pharmaceutical and agrochemical synthesis. The cyclopropyl ring enhances steric and electronic properties, influencing binding affinity and metabolic stability in drug development. Its piperazine backbone offers flexibility for further functionalization, enabling diverse derivatization pathways. The compound is particularly useful as an intermediate in the preparation of biologically active molecules, including CNS-targeting agents and antimicrobials. High purity grades are available to meet stringent research and industrial requirements. Proper handling under inert conditions is recommended due to its sensitivity to moisture and air.
1-(Cyclopropylmethyl)piperazine structure
57184-25-5 structure
Product Name:1-(Cyclopropylmethyl)piperazine
CAS No:57184-25-5
MF:C8H16N2
MW:140.226041793823
MDL:MFCD00872053
CID:366791
PubChem ID:24884384
Update Time:2025-05-22

1-(Cyclopropylmethyl)piperazine Chemical and Physical Properties

Names and Identifiers

    • 1-(Cyclopropylmethyl)piperazine
    • Piperazine,1-(cyclopropylmethyl)-
    • N-(Cyclopropylmethyl)piperazine
    • 1-Cyclopropylmethylpiperazine
    • PIPERAZINE, 1-(CYCLOPROPYLMETHYL)-
    • (cyclopropylmethyl)piperazine
    • n-cyclopropylmethylpiperazine
    • 1-Cyclopropylmethyl-piperazine
    • 4-(cyclopropylmethyl)piperazine
    • ARONIS005786
    • 1-(Cyclopropylmethyl)-piperazine
    • IVLIBVDZIYFXBZ-UHFFFAOYSA-N
    • BCP11899
    • 8397AB
    • STL426793
    • BBL034798
    • KM0075
    • SBB080020
    • [(Piperazin-1-
    • 57184-25-5
    • FT-0690727
    • EN300-49539
    • SY310269
    • FT-0678135
    • PB26040
    • J-503543
    • CS-0011260
    • AKOS000319545
    • SY002916
    • AMY5266
    • A831339
    • 4-(Cyclopropylmethyl)piperazine; N-(Cyclopropylmethyl)piperazine
    • DTXSID80359487
    • 1-(CYCLOPROPYLMETHYL)PIPERAZINE 97
    • AC-2789
    • MFCD00872053
    • BB 0237085
    • SCHEMBL92626
    • 1-(Cyclopropylmethyl)piperazine, 97%
    • DS-10729
    • MDL： MFCD00872053
    • Inchi： 1S/C8H16N2/c1-2-8(1)7-10-5-3-9-4-6-10/h8-9H,1-7H2
    • InChI Key： IVLIBVDZIYFXBZ-UHFFFAOYSA-N
    • SMILES： N1(CCNCC1)CC1CC1

Computed Properties

  • Exact Mass: 140.13100
  • Monoisotopic Mass: 140.131348519g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 2
  • Complexity: 104
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 15.3
  • XLogP3: 0.4

Experimental Properties

  • Density: 0.943?g/mL?at 25?°C
  • Boiling Point: 68?°C/3.5?mmHg
  • Flash Point: Degrees Fahrenheit:170.6°F
    Degrees Celsius:77°C
  • Refractive Index: n20/D 1.489
  • Solubility: Soluble (154 g/l) (25 o C),
  • PSA: 15.27000
  • LogP: 0.56830

1-(Cyclopropylmethyl)piperazine Security Information

  • Symbol: GHS05
  • Signal Word：Danger
  • Hazard Statement： H318
  • Warning Statement： P280-P305+P351+P338
  • Hazardous Material transportation number：NA 1993 / PGIII
  • WGK Germany：2
  • Hazard Category Code： 41
  • Safety Instruction： S26; S36/39
  • Hazardous Material Identification： Xi
  • Risk Phrases：R41
  • Storage Condition：2-8°C

1-(Cyclopropylmethyl)piperazine Customs Data

  • HS CODE：2933599090
  • Customs Data：

    China Customs Code:

    2933599090

    Overview:

    2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-(Cyclopropylmethyl)piperazine Pricemore >>

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1-(Cyclopropylmethyl)piperazine Production Method

1-(Cyclopropylmethyl)piperazine Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:57184-25-5)1-環(huán)丙甲基哌嗪
Order Number:LE25979620
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:54
Price ($):discuss personally

1-(Cyclopropylmethyl)piperazine Related Literature

Additional information on 1-(Cyclopropylmethyl)piperazine

1-(Cyclopropylmethyl)piperazine: A Comprehensive Overview

The compound 1-(Cyclopropylmethyl)piperazine (CAS No. 57184-25-5) is a fascinating molecule with a unique structure that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound belongs to the piperazine family, which is a six-membered ring containing two nitrogen atoms. The cyclopropylmethyl group attached to the piperazine ring introduces interesting stereochemical and electronic properties, making it a valuable substrate for various chemical transformations and applications.

Recent studies have highlighted the potential of 1-(Cyclopropylmethyl)piperazine in drug discovery. Its ability to act as a building block for more complex molecules has been extensively explored. For instance, researchers have utilized this compound to synthesize bioactive agents targeting various therapeutic areas, including central nervous system disorders and cancer. The cyclopropylmethyl group's strain energy and reactivity have been shown to enhance the pharmacokinetic properties of derived compounds, making them more promising candidates for drug development.

In terms of synthesis, 1-(Cyclopropylmethyl)piperazine can be prepared through several methods, including nucleophilic substitution and coupling reactions. One notable approach involves the reaction of cyclopropylmethanol with piperazine under specific conditions to form the desired product. This method has been optimized in recent studies to improve yield and purity, ensuring scalability for industrial applications.

The structural uniqueness of 1-(Cyclopropylmethyl)piperazine also lends itself well to click chemistry applications. The presence of strained rings like cyclopropane allows for efficient formation of covalent bonds under mild conditions, which is particularly advantageous in medicinal chemistry. For example, researchers have employed this compound in the construction of macrocyclic structures, which are known for their stability and potential as drug delivery vehicles.

From an analytical standpoint, the characterization of 1-(Cyclopropylmethyl)piperazine has been enhanced by modern spectroscopic techniques. High-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) spectroscopy have provided detailed insights into its molecular structure and purity. These advancements have enabled precise quality control measures, ensuring that the compound meets stringent pharmaceutical standards.

Looking ahead, the versatility of 1-(Cyclopropylmethyl)piperazine suggests that it will continue to play a pivotal role in chemical research and development. Its integration into advanced synthetic strategies and its potential as a precursor for novel bioactive agents underscore its importance in contemporary science. As research progresses, further insights into its properties and applications are expected to emerge, solidifying its position as a key molecule in organic chemistry.

57184-25-5 (1-(Cyclopropylmethyl)piperazine) Related Products

Recommended suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:57184-25-5)1-環(huán)丙甲基哌嗪
LE25979620
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry
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