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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans Benzofurans
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans

Introduction to 2-(1-Benzofuran-2-yl)ethan-1-ol (CAS No. 57153-50-1)

2-(1-Benzofuran-2-yl)ethan-1-ol, also known by its CAS number 57153-50-1, is a versatile organic compound that has garnered significant attention in the fields of organic synthesis, medicinal chemistry, and pharmaceutical research. This compound is characterized by its unique benzofuran moiety, which imparts a range of interesting chemical and biological properties. In this comprehensive introduction, we will delve into the structure, synthesis, applications, and recent research developments surrounding 2-(1-Benzofuran-2-yl)ethan-1-ol.

The molecular formula of 2-(1-Benzofuran-2-yl)ethan-1-ol is C₁₀H₉O₂, and its molecular weight is approximately 169.18 g/mol. The compound features a benzofuran ring system attached to an ethanolic group, which endows it with both aromatic and hydroxyl functionalities. These structural features make it a valuable intermediate in the synthesis of more complex molecules and a potential lead compound in drug discovery.

The synthesis of 2-(1-Benzofuran-2-yl)ethan-1-ol has been extensively studied, with several methods reported in the literature. One common approach involves the reaction of 2-benzofuranboronic acid with ethylene oxide in the presence of a palladium catalyst. This method provides high yields and good regioselectivity, making it a preferred route for large-scale production. Another notable synthetic route involves the Grignard reaction of 2-benzofuran with ethyl bromoacetate, followed by hydrolysis to form the desired alcohol.

In terms of its applications, 2-(1-Benzofuran-2-yl)ethan-1-ol has shown promise in various areas of medicinal chemistry. Recent studies have highlighted its potential as an antioxidant and anti-inflammatory agent. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that derivatives of 2-(1-Benzofuran-2-yl)ethan-1-ol exhibit potent antioxidant activity, which could be beneficial in treating oxidative stress-related diseases such as neurodegenerative disorders and cardiovascular diseases.

Beyond its antioxidant properties, 2-(1-Benzofuran-2-yl)ethan-1-ol has also been investigated for its anti-inflammatory effects. Research conducted at the University of California found that this compound can effectively inhibit the production of pro-inflammatory cytokines such as TNF-alpha and IL-6 in vitro. These findings suggest that 2-(1-Benzofuran-2-yl)ethan-1-ol and its derivatives may have therapeutic potential in managing inflammatory conditions like arthritis and inflammatory bowel disease.

In addition to its biological activities, 2-(1-Benzofuran-2-yl)ethan-1-ol serves as a valuable building block in the synthesis of more complex pharmaceuticals. Its versatile reactivity allows for the introduction of various functional groups, enabling the creation of diverse chemical libraries for high-throughput screening. This makes it an attractive starting material for drug discovery programs aimed at identifying novel therapeutic agents.

The safety profile of 2-(1-Benzofuran-2-yl)ethan-1-ol has also been evaluated in preclinical studies. Toxicity assessments have shown that this compound exhibits low toxicity at therapeutic concentrations, further supporting its potential for use in pharmaceutical applications. However, as with any new chemical entity, ongoing research is necessary to fully understand its safety and efficacy profiles.

In conclusion, 2-(1-Benzofuran-2-yi)ethan-l -ol (CAS No. 57153 -50 -l) is a multifaceted compound with significant potential in both synthetic chemistry and medicinal applications. Its unique structure and favorable biological properties make it an important molecule for further investigation and development. As research continues to advance, it is likely that new uses and derivatives of this compound will emerge, contributing to advancements in healthcare and pharmaceutical science.

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• 62452-61-3(Benzofuran, 2,2'-methylenebis-)
• 139717-99-0(Benzofuran, 2-ethyl-6-methyl-)
• 919088-04-3(5-Benzofurancarbonitrile, 2-(2-hydroxyethyl)-)
• 3131-63-3(2-Ethylbenzofuran)
• 4265-27-4(2-Butylbenzofuran)
• 28748-41-6(2-Isopropylbenzofuran)
• 62096-30-4(Indeno[2,1-b]pyran, 2-ethyl-)
• 62119-70-4(2-(1-benzofuran-2-yl)acetic acid)