• 1. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 2. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 3. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 4. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 5. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes Nitrobenzaldehydes

Comprehensive Overview of 4,5-Dichloro-2-nitrobenzaldehyde (CAS No. 56990-04-6): Properties, Applications, and Industry Insights

4,5-Dichloro-2-nitrobenzaldehyde (CAS No. 56990-04-6) is a specialized organic compound widely recognized for its versatile applications in pharmaceutical intermediates, agrochemical synthesis, and material science. This yellow crystalline solid belongs to the family of nitrobenzaldehyde derivatives, characterized by its unique molecular structure featuring two chlorine atoms and a nitro group attached to a benzaldehyde core. Its chemical formula C7H3Cl2NO3 and molecular weight of 220.01 g/mol make it a critical building block in modern synthetic chemistry.

In recent years, the demand for high-purity 4,5-Dichloro-2-nitrobenzaldehyde has surged due to its role in developing advanced pharmaceutical compounds. Researchers particularly value its reactivity in Pd-catalyzed cross-coupling reactions, which are essential for creating complex molecular architectures. The compound's electron-withdrawing groups (chloro and nitro) enhance its utility in nucleophilic aromatic substitution reactions, a topic frequently searched in academic databases and AI-driven chemistry platforms.

From an industrial perspective, 56990-04-6 has gained attention in green chemistry initiatives. Manufacturers now focus on solvent-free synthesis methods and catalytic reduction processes to minimize environmental impact—a hot topic aligning with global sustainability trends. Analytical techniques like HPLC purity testing and GC-MS characterization ensure batch-to-batch consistency, addressing quality concerns frequently raised in supplier evaluations.

The thermal stability of 4,5-Dichloro-2-nitrobenzaldehyde (decomposition point >200°C) makes it suitable for high-temperature reactions, while its solubility profile (soluble in DMSO, DMF; sparingly soluble in water) enables diverse application scenarios. These physicochemical properties are often queried in chemical databases, reflecting user interest in process optimization. Recent patent literature highlights its growing use in OLED material development, where its electron-accepting properties contribute to improved device efficiency.

Quality standards for CAS 56990-04-6 have become more stringent, with leading suppliers now offering ≥98% purity grades accompanied by detailed spectroscopic data sheets (IR, NMR). The compound's shelf life under proper storage conditions (2-8°C in amber glass) and handling precautions are frequently discussed in laboratory safety forums. Analytical challenges such as isomeric separation during production have spurred methodological innovations documented in recent Journal of Organic Chemistry publications.

Emerging applications in bioconjugation chemistry leverage the aldehyde group's reactivity for protein labeling studies. This aligns with current biomedical research trends toward targeted drug delivery systems. The compound's role in synthesizing heterocyclic scaffolds for kinase inhibitors remains a active area of investigation, as evidenced by its mention in over 50 recent medicinal chemistry publications indexed in SciFinder.

Market analysis indicates steady growth in the 4,5-Dichloro-2-nitrobenzaldehyde supply chain, with Asia-Pacific regions showing particular demand expansion. Regulatory compliance documentation (including REACH registration dossiers) and custom synthesis options are now key differentiators among suppliers. Technical discussions often focus on large-scale crystallization techniques to improve yield—a practical concern for industrial chemists frequently searching optimization strategies.

From a research perspective, the compound's X-ray crystallography data (CCDC deposition numbers available) provides valuable insights into molecular packing interactions. Computational chemistry studies utilizing DFT calculations have modeled its frontier orbitals, contributing to the understanding of its reactivity patterns—a subject of numerous graduate-level organic chemistry queries. The compound's distinctive 13C NMR shifts (particularly the aldehyde carbon at ~190 ppm) serve as diagnostic markers referenced in spectroscopic identification guides.

Innovative applications continue to emerge, including recent work on metal-organic frameworks (MOFs) incorporating derivatives of 56990-04-6 as structural linkers. The compound's compatibility with continuous flow chemistry setups addresses industry's growing preference for process intensification. These developments position 4,5-Dichloro-2-nitrobenzaldehyde as a compound of enduring relevance in both academic and industrial chemistry landscapes.

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