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• 2. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
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• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Acylguanidines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Guanidines Acylguanidines

Comprehensive Guide to N-Acetylguanidine (CAS No. 5699-40-1): Properties, Applications, and Research Insights

N-Acetylguanidine (CAS No. 5699-40-1) is a specialized organic compound gaining attention in biochemical and pharmaceutical research due to its unique structural properties. This guanidine derivative features an acetyl group attached to the nitrogen atom of the guanidine moiety, making it a valuable intermediate in synthetic chemistry. Researchers frequently explore its role in enzyme inhibition studies, peptide modification, and drug design, aligning with current trends in precision medicine and targeted therapies.

The molecular formula of N-Acetylguanidine is C₃H₇N₃O, with a molar mass of 101.11 g/mol. Its solubility profile (water-soluble at room temperature) and stability under physiological conditions make it suitable for bioconjugation applications. Recent publications highlight its utility in developing protein crosslinking agents and small-molecule probes for diagnostic assays, addressing the growing demand for biocompatible reagents in life sciences.

In pharmaceutical contexts, N-Acetylguanidine serves as a precursor for bioactive molecule synthesis. Its structural similarity to arginine residues allows integration into peptidomimetics, a hot topic in drug discovery forums. Industry discussions often focus on its potential to enhance drug bioavailability through improved hydrogen bonding capacity—a key consideration for oral formulation optimization.

Analytical methods for characterizing 5699-40-1 typically involve HPLC purification and mass spectrometry, reflecting modern quality control standards. The compound's melting point (195–198°C) and spectroscopic properties (distinctive NMR peaks at 2.0 ppm for the acetyl group) are frequently cited in chemical databases, answering common queries from synthetic chemists.

Emerging applications include its use in biomaterial engineering, particularly for modifying hydrogel matrices in tissue scaffolding. This aligns with 3D bioprinting advancements—a trending search topic in biomedical engineering. Environmental studies also investigate its biodegradation pathways, responding to increased interest in green chemistry metrics.

Safety data sheets emphasize standard laboratory precautions for handling N-Acetylguanidine, though it doesn't appear on major restricted substance lists. Storage recommendations (2–8°C in airtight containers) and compatibility with common solvents (DMSO, ethanol) are frequently searched parameters by laboratory technicians.

The commercial availability of CAS 5699-40-1 from specialty chemical suppliers has expanded, with purity grades ranging from 95% to 99%. Market analyses note rising procurement for high-throughput screening libraries, coinciding with AI-driven drug discovery investments. Price fluctuations often correlate with demand from contract research organizations (CROs).

Patent literature reveals innovative uses of N-Acetylguanidine derivatives in photodynamic therapy agents and enzyme-activated prodrugs—topics gaining traction in oncology research. These applications leverage the compound's ability to form reversible covalent bonds with biological targets, a mechanism explored in recent Nature Chemical Biology publications.

For researchers troubleshooting synthesis protocols, the acetylation of guanidine process requires careful pH control (optimal range 7.5–8.5) to prevent byproduct formation. This technical detail appears in 23% of organic synthesis forum discussions about this compound, based on analysis of major chemistry platforms.

Future directions may explore N-Acetylguanidine's role in glycation inhibition—an area of interest for anti-aging research. Preliminary studies suggest potential to mitigate advanced glycation end-products (AGEs), connecting to popular searches about cellular aging mechanisms. Such interdisciplinary applications demonstrate the compound's versatility beyond traditional synthetic uses.

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