Cas no 56621-48-8 (N-(4-Hydroxyphenyl)piperazine)
N-(4-Hydroxyphenyl)piperazine is a versatile chemical intermediate widely used in pharmaceutical and organic synthesis. Its phenolic hydroxyl group and piperazine moiety make it a valuable building block for designing active pharmaceutical ingredients (APIs), particularly in the development of CNS-targeting drugs and receptor modulators. The compound exhibits favorable reactivity for functionalization, enabling the introduction of diverse substituents. Its structural features also contribute to improved solubility and bioavailability in derived compounds. As a high-purity synthetic intermediate, it ensures consistent performance in research and industrial applications, supporting efficient scale-up processes. Proper handling is advised due to its potential reactivity under certain conditions.
N-(4-Hydroxyphenyl)piperazine structure
Product Name:N-(4-Hydroxyphenyl)piperazine
CAS No:56621-48-8
MF:C10H14N2O
MW:178.230962276459
MDL:MFCD00066156
CID:56992
PubChem ID:92467
Update Time:2025-07-14
N-(4-Hydroxyphenyl)piperazine Chemical and Physical Properties
Names and Identifiers
-
- 1-(4-Hydroxyphenyl)piperazine
- 4-(1-Piperazino)phenol
- 4-(piperazin-1-yl)phenol
- 4-piperazin-1-ylphenol
- 4-(1-Piperazinyl)phenol
- N-(4-hydroxyphenyl)piperazine
- p-(1-Piperazinyl)phenol
- 4-Piperazinophenol
- 1-(4-Hydroxyphenyl)-piperazine
- Phenol, 4-(1-piperazinyl)-
- 4-piperazinylphenol
- 4-Piperazinyl phenol
- 4-piperazin-1-yl-phenol
- 4-hydroxy phenylpiperazine
- 4-piperazine-1-yl-phenol
- 4-(piperazine-1-yl)phenol
- Oprea1_539482
- 4-(piperazin-1-yl)-phenol
- 4
- H0891
- N-(4-Hydroxyphenyl)piperazine;4-Piperazin-1-yl-phenol;4-Piperazinophenol
- AM20060673
- F14231
- BDBM626043
- AKOS001044007
- A2SA24RA7S
- A26636
- AC-8984
- F2158-0909
- 4-(4-hydroxyphenyl)piperazine
- CS-W017311
- NS00033553
- EN300-17230
- EINECS 260-289-6
- DTXSID80205197
- MFCD00066156
- 4-HYDROXYPHENYLPIPERAZINE
- FS-3772
- 56621-48-8
- HMS1786O12
- SY021141
- Z56899148
- N-(4-hydroxyphenyl)-piperazine
- GPEOAEVZTOQXLG-UHFFFAOYSA-N
- FT-0629230
- SCHEMBL40343
- 1-(4-Hydroxyphenyl)piperazine, >=98.0% (NT)
- W-105507
- AE-641/30153018
- STK585941
- DB-005595
- BBL036783
- N-(4-Hydroxyphenyl)piperazine
-
- MDL： MFCD00066156
- Inchi： 1S/C10H14N2O/c13-10-3-1-9(2-4-10)12-7-5-11-6-8-12/h1-4,11,13H,5-8H2
- InChI Key： GPEOAEVZTOQXLG-UHFFFAOYSA-N
- SMILES： OC1C=CC(=CC=1)N1CCNCC1
- BRN： 150964
Computed Properties
- Exact Mass: 178.11100
- Monoisotopic Mass: 178.111
- Isotope Atom Count: nothing
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 13
- Rotatable Bond Count: 1
- Complexity: 149
- Covalently-Bonded Unit Count: nothing
- Defined Atom Stereocenter Count: nothing
- Undefined Atom Stereocenter Count : nothing
- Defined Bond Stereocenter Count: nothing
- Undefined Bond Stereocenter Count: nothing
- Surface Charge: nothing
- Tautomer Count: nothing
- XLogP3: 0.8
- Topological Polar Surface Area: 35.5
Experimental Properties
- Color/Form: powder
- Density: 1.141
- Melting Point: 220-225?°C
- Boiling Point: 371.3 °C at 760 mmHg
- Flash Point: 178.3 °C
- Refractive Index: 1.576
- PSA: 35.50000
- LogP: 1.19560
- Solubility: Soluble
N-(4-Hydroxyphenyl)piperazine Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Warning
- Hazard Statement： H315-H319
- Warning Statement： P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
- Hazardous Material transportation number：UN3263
- WGK Germany：3
- Hazard Category Code： 36/37/38
- Safety Instruction： S26-S36
- FLUKA BRAND F CODES：10-34
-
Hazardous Material Identification：
- Packing Group：III
- Hazard Level：8
- HazardClass：8
- PackingGroup：III
- Storage Condition：Store at room temperature
- Safety Term：8
- Packing Group：III
- Risk Phrases：R36/37/38
N-(4-Hydroxyphenyl)piperazine Customs Data
- HS CODE：2933599090
- Customs Data：
China Customs Code:
2933599090Overview:
2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
N-(4-Hydroxyphenyl)piperazine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 009797-100g |
1-(4-Hydroxyphenyl)-piperazine |
56621-48-8 | 97% | 100g |
￡70.00 | 2022-02-28 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | H134059-10g |
N-(4-Hydroxyphenyl)piperazine |
56621-48-8 | ≥98% | 10g |
￥55.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | H134059-5g |
N-(4-Hydroxyphenyl)piperazine |
56621-48-8 | ≥98% | 5g |
￥29.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | H134059-25g |
N-(4-Hydroxyphenyl)piperazine |
56621-48-8 | ≥98% | 25g |
￥110.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | H134059-50g |
N-(4-Hydroxyphenyl)piperazine |
56621-48-8 | ≥98% | 50g |
￥159.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | H134059-100g |
N-(4-Hydroxyphenyl)piperazine |
56621-48-8 | ≥98% | 100g |
￥255.90 | 2023-09-02 | |
| ChemScence | CS-W017311-100g |
4-(Piperazin-1-yl)phenol |
56621-48-8 | 99.94% | 100g |
$76.0 | 2022-04-27 | |
| Chemenu | CM120134-100g |
4-(1-Piperazinyl)phenol |
56621-48-8 | 95%+ | 100g |
$*** | 2023-05-30 | |
| Apollo Scientific | OR6840-25g |
4-(Piperazin-1-yl)phenol |
56621-48-8 | 98% | 25g |
￡71.00 | 2023-09-01 | |
| Apollo Scientific | OR6840-100g |
4-(Piperazin-1-yl)phenol |
56621-48-8 | 98+% | 100g |
￡42.00 | 2024-05-25 |
N-(4-Hydroxyphenyl)piperazine Suppliers
Shanghai Jinhuan Chemical CO., LTD.
Gold Member
Audited Supplier
(CAS:56621-48-8)1-(4-Hydroxyphenyl)piperazine
Order Number:JH088;JH317
Stock Status:in Stock
Quantity:25kg
Purity:98.00%
Pricing Information Last Updated:Monday, 8 January 2024 17:37
Price ($): negotiated
Email:[email protected]
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier
(CAS:56621-48-8)4-羥基苯基哌嗪
Order Number:LE2599816
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:41
Price ($):discuss personally
Email:[email protected]
N-(4-Hydroxyphenyl)piperazine Related Literature
-
Fangyu Du,Qifan Zhou,Xiaoxiao Fu,Yajie Shi,Yuanguang Chen,Wuhong Fang,Jingyu Yang,Guoliang Chen RSC Adv. 2019 9 2498
-
Mahdi Jamshidi,Ameneh Amani,Sadegh Khazalpour,Sara Torabi,Davood Nematollahi New J. Chem. 2021 45 18246
56621-48-8 (N-(4-Hydroxyphenyl)piperazine) Related Products
- 74853-08-0(4-4-(4-Aminophenyl)-1-piperazinylphendiamineol)
- 163210-63-7(4-(4-methyl-1-piperazinyl)-Phenol)
- 111494-88-3(5-(1-piperazinyl)-1,3-Benzenediol)
- 59817-32-2(1-(3-HYDROXYPHENYL)PIPERAZINE)
- 38869-37-3(4-Piperazinophenol DihydrobromideDISCONTINUED SEE H949465)
- 67914-97-0(4-(4-Isopropylpiperazin-1-yl)phenol)
- 807624-37-9(3-(piperazin-1-yl)phenol hydrochloride)
- 177489-10-0(3-(4-METHYLPIPERAZIN-1-YL)PHENOL)
- 1175036-51-7(4-(piperazin-1-yl)phenol hydrochloride)
- 189350-02-5(8-(1-piperazinyl)-2-Naphthalenol)
Recommended suppliers
Shanghai Jinhuan Chemical CO., LTD.
(CAS:56621-48-8)1-(4-Hydroxyphenyl)piperazine
Purity:98.00%/98.00%
Quantity:25kg/25kg
Price ($):Inquiry/Inquiry
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:56621-48-8)4-羥基苯基哌嗪
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry