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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

D-alanine-2-d1 (CAS No. 56595-54-1): An Overview of Its Properties, Applications, and Recent Research Advances

D-alanine-2-d1 (CAS No. 56595-54-1) is a deuterated derivative of the amino acid D-alanine. This compound is of significant interest in various scientific and pharmaceutical applications due to its unique properties and the advantages it offers in research and development. In this comprehensive overview, we will delve into the chemical structure, physical properties, applications, and recent advancements in the study of D-alanine-2-d1.

Chemical Structure and Physical Properties

D-alanine-2-d1 is a deuterated form of D-alanine, where one of the hydrogen atoms on the methyl group is replaced by a deuterium atom. The chemical formula for D-alanine-2-d1 is C3H6DNO2. The presence of deuterium, a stable isotope of hydrogen with an atomic mass of 2, imparts distinct physical and chemical properties to the molecule compared to its non-deuterated counterpart.

The molecular weight of D-alanine-2-d1 is approximately 87.08 g/mol, slightly higher than that of D-alanine (86.09 g/mol) due to the additional mass of the deuterium atom. This difference in molecular weight can be advantageous in various analytical techniques, such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, where isotopic labeling can enhance the detection and quantification of compounds.

D-alanine-2-d1 is a white crystalline solid at room temperature and is soluble in water and many organic solvents. Its solubility properties make it suitable for use in a wide range of experimental conditions. The compound exhibits a melting point of around 243-245°C, which is consistent with other amino acids but may vary slightly due to the presence of deuterium.

Applications in Research and Development

D-alanine-2-d1 finds extensive use in various research fields, particularly in biochemistry, biophysics, and pharmaceutical sciences. One of its primary applications is as an isotopic label in NMR spectroscopy studies. Deuterium labeling can significantly improve the resolution and sensitivity of NMR spectra, making it easier to study complex biomolecular interactions and structures.

In protein structure determination, D-alanine-2-d1 can be incorporated into peptides or proteins to enhance the visibility of specific regions or residues. This is particularly useful in structural biology studies where high-resolution data are required to understand protein function and dynamics.

D-alanine-2-d1 is also employed in metabolic studies to trace the fate of specific amino acids within biological systems. Deuterium-labeled compounds can be used to monitor metabolic pathways, enzyme activities, and cellular processes with high precision. This application has significant implications for understanding disease mechanisms and developing targeted therapies.

Recent Research Advances

The use of deuterated compounds like D-alanine-2-d1 has been instrumental in several recent research breakthroughs. For instance, a study published in the Journal of Biological Chemistry explored the role of D-alanine in bacterial cell wall biosynthesis using deuterium-labeled analogs. The researchers found that deuterium labeling provided valuable insights into the kinetics and mechanism of D-alanine incorporation into peptidoglycan precursors.

In another study published in Nature Communications, scientists used D-alanine-2-d1 to investigate the structural dynamics of membrane proteins involved in antibiotic resistance. The deuterium labeling allowed for high-resolution NMR studies that revealed critical details about protein conformational changes upon ligand binding.

Beyond basic research, D-alanine-2-d1 has shown promise in drug development applications. A recent paper in the Journal of Medicinal Chemistry reported the use of deuterated amino acids to improve the pharmacokinetic properties of small molecule drugs. By incorporating deuterium into key positions within drug molecules, researchers were able to enhance their stability and bioavailability, leading to more effective therapeutic outcomes.

Safety Considerations and Handling

D-alanine-2-d1 is generally considered safe for laboratory use when proper handling protocols are followed. However, like any chemical compound, it should be handled with care to avoid inhalation or skin contact. It is recommended to store D-alanine-2-d1 strong> in a cool, dry place away from direct sunlight and incompatible materials.

Laboratory personnel should wear appropriate personal protective equipment (PPE), including gloves, goggles, and lab coats when working with this compound. In case of accidental exposure or spillage, standard safety procedures should be followed as outlined by local regulations and guidelines.

Conclusion

D-alanine-2-d1 strong> (CAS No. 56595-54-1) is a valuable tool in modern scientific research due to its unique isotopic properties and versatile applications. From enhancing NMR spectroscopy studies to improving drug development processes, this compound continues to play a crucial role in advancing our understanding of biological systems and developing innovative therapeutic strategies.

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