Cas no 56552-80-8 ((2R)-3-(benzyloxy)propane-1,2-diol)

(2R)-3-(Benzyloxy)propane-1,2-diol is a chiral diol derivative featuring a benzyl-protected hydroxyl group, commonly employed as a versatile intermediate in organic synthesis and pharmaceutical applications. Its stereospecific (R)-configuration makes it valuable for asymmetric synthesis, particularly in the preparation of enantiomerically pure compounds. The benzyloxy group enhances solubility in organic solvents while allowing selective deprotection under mild conditions. This compound is particularly useful in the synthesis of glycidol derivatives, nucleoside analogs, and other fine chemicals requiring precise stereocontrol. Its stability under a range of reaction conditions and compatibility with common protecting group strategies further contribute to its utility in multistep synthetic routes.

(2R)-3-(benzyloxy)propane-1,2-diol structure

56552-80-8 structure

Product Name:(2R)-3-(benzyloxy)propane-1,2-diol

CAS No:56552-80-8

MF:C₁₀H₁₄O₃

MW:182.216363430023

MDL:MFCD00067260

CID:383662

PubChem ID:24867485

Update Time:2025-11-01

(2R)-3-(benzyloxy)propane-1,2-diol Chemical and Physical Properties

Names and Identifiers

- (R)-3-(Benzyloxy)propane-1,2-diol
- (R)-(+)-3-Benzyloxy-1,2-propanediol
- 1,2-Propanediol, 3-(phenylmethoxy)-, (2R)-
- 3-O-Benzyl-sn-glycerol
- 1-O-BENZYL-RAC-GLYCEROL
- 3-Benzyloxy-1,1-dimethoxypropane
- (R)-(+)-Glycerol α-Benzyl Ether
- 3-Benzyl-sn-glycerol
- (R)-3-Benzyloxy-1,2-propanediol
- (2R)-3-(benzyloxy)propane-1,2-diol
- LWCIBYRXSHRIAP-SNVBAGLBSA-N
- (r)-(+)-1-benzylglycerol
- (2R)-3-phenylmethoxypropane-1,2-diol
- 1-O-Benzyl-D-glycerol
- L-alpha-O-benzylglycerol
- 1-O-benzyl-(R)-glycerol
- 3-benzyloxypropane-1,2-diol
- (R)-Glycerol 1-benzyl ether
- EOS374
- BDBM36009
- (R)-3-benzyloxypropane-1,2-dio
- (R)-(-)-3-Benzyloxy-1,2-propanediol
- B2141
- (R)-(+)-3-Benzyloxy-1,2-propanediol, 99%
- (R)-3-(benzyloxy) propane-1,2-diol
- CS-W017112
- MFCD00067260
- (R)-(+)-Glycerol alpha-Benzyl Ether
- (R)-3-benzyloxypropane-1,2-diol
- SCHEMBL218661
- 56552-80-8
- AS-18923
- (R)-(+)-3-Benzyloxy-1,2-propanediol, puriss., >=99.0% (sum of enantiomers, GC)
- AKOS015839317
- E10194
- MDL： MFCD00067260
- Inchi： 1S/C10H14O3/c11-6-10(12)8-13-7-9-4-2-1-3-5-9/h1-5,10-12H,6-8H2/t10-/m1/s1
- InChI Key： LWCIBYRXSHRIAP-SNVBAGLBSA-N
- SMILES： O(CC1C=CC=CC=1)C[C@@H](CO)O

Computed Properties

Exact Mass: 182.09400
Monoisotopic Mass: 182.094
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 3
Heavy Atom Count: 13
Rotatable Bond Count: 5
Complexity: 121
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 1
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: nothing
XLogP3: 0.3
Topological Polar Surface Area: 49.7

Experimental Properties

Color/Form: liquid
Density: 1.140?g/mL?at 20?°C(lit.)
Melting Point: 25-29?°C (lit.)
Boiling Point: 355.1 ℃ at 760 mmHg
Flash Point: Degrees Fahrenheit:235.4°F
Degrees Celsius:113°C
Refractive Index: n20/D 1.533
Stability/Shelf Life: Stable, but moisture sensitive. Incompatible with strong oxidizing agents.
PSA: 49.69000
LogP: 0.55640
Solubility: Not determined
Specific Rotation: 5.5 o (c=20 in chloroform)
Optical Activity: [α]20/D +5.5°, c =?20 in chloroform

(2R)-3-(benzyloxy)propane-1,2-diol Security Information

Signal Word：Warning
Hazard Statement： H315; H319; H335
Warning Statement： P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：3
Safety Instruction： S22-S24/25
FLUKA BRAND F CODES：3-9
RTECS：TY3180000
Safety Term：S22-S24/25
Risk Phrases：R22
Storage Condition：0-10°C

(2R)-3-(benzyloxy)propane-1,2-diol Customs Data

HS CODE：2909499000
Customs Data：

China Customs Code:
2909499000

Overview:

2909499000 Other ether alcohols and their halogenation\sulfonation\Nitrosative or nitrosative derivatives. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%

Declaration elements:

Product Name, component content, use to

Summary:

2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

(2R)-3-(benzyloxy)propane-1,2-diol Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	R139002-100mg	(2R)-3-(benzyloxy)propane-1,2-diol	56552-80-8	≥98.0%(GC)	100mg	￥53.90	2023-09-01
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	R139002-1g	(2R)-3-(benzyloxy)propane-1,2-diol	56552-80-8	≥98.0%(GC)	1g	￥192.90	2023-09-01
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	R139002-25mg	(2R)-3-(benzyloxy)propane-1,2-diol	56552-80-8	≥98.0%(GC)	25mg	￥30.90	2023-09-01
Alichem	A019139300-5g	(R)-3-(Benzyloxy)propane-1,2-diol	56552-80-8	97%	5g	$530.25	2023-09-01
TRC	B287555-100mg	(R)-(+)-3-Benzyloxy-1,2-propanediol	56552-80-8		100mg	$ 69.00	2023-04-18
TRC	B287555-250mg	(R)-(+)-3-Benzyloxy-1,2-propanediol	56552-80-8		250mg	$ 92.00	2023-04-18
TRC	B287555-500mg	(R)-(+)-3-Benzyloxy-1,2-propanediol	56552-80-8		500mg	$ 127.00	2023-04-18
TRC	B287555-1g	(R)-(+)-3-Benzyloxy-1,2-propanediol	56552-80-8		1g	$ 130.00	2022-06-07
TRC	B287555-2.5g	(R)-(+)-3-Benzyloxy-1,2-propanediol	56552-80-8		2.5g	$ 339.00	2023-04-18
TRC	B287555-5g	(R)-(+)-3-Benzyloxy-1,2-propanediol	56552-80-8		5g	$ 483.00	2023-04-18

(2R)-3-(benzyloxy)propane-1,2-diol Production Method

(2R)-3-(benzyloxy)propane-1,2-diol Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

Audited Supplier

(CAS:56552-80-8)(2R)-3-(benzyloxy)propane-1,2-diol

Order Number:LE5601

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 11:47

Price ($):discuss personally

Email:[email protected]

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Additional information on (2R)-3-(benzyloxy)propane-1,2-diol

Comprehensive Overview of (2R)-3-(benzyloxy)propane-1,2-diol (CAS No. 56552-80-8): Properties, Applications, and Industry Insights

(2R)-3-(benzyloxy)propane-1,2-diol (CAS No. 56552-80-8) is a chiral organic compound with significant relevance in pharmaceutical synthesis, specialty chemicals, and material science. Its molecular structure features a benzyl-protected diol moiety, making it a versatile intermediate for asymmetric synthesis. The compound's stereospecificity (R-configuration) is critical for applications requiring enantiomeric purity, such as drug development and fine chemical manufacturing.

Recent trends in green chemistry and sustainable synthesis have amplified interest in this compound. Researchers are exploring its role in biocatalysis and enzyme-mediated reactions, addressing frequent search queries like "chiral building blocks for APIs" or "benzyl ether protecting group alternatives." The compound's low toxicity profile and compatibility with microwave-assisted synthesis further align with modern laboratory priorities.

Analytical characterization of 56552-80-8 typically involves HPLC chiral separation, NMR spectroscopy, and mass spectrometry. Industry professionals often search for "CAS 56552-80-8 purity standards" or "(2R)-3-(benzyloxy)propane-1,2-diol synthetic routes," reflecting demand for technical specifications. The compound's melting point range (78-82°C) and solubility in polar aprotic solvents are frequently documented parameters.

In pharmaceutical applications, this chiral synthon serves as a precursor for β-blocker analogs and glycidyl ether derivatives. Patent literature reveals its utility in kinase inhibitor scaffolds, correlating with trending searches for "small molecule drug intermediates." Regulatory compliance aspects, particularly ICH Q7 guidelines for chiral substances, are increasingly associated with this compound in GMP environments.

The material science sector utilizes (2R)-3-(benzyloxy)propane-1,2-diol for polyurethane modifications and epoxy resin formulations. Its dual hydroxyl functionality enables crosslinking reactions, with industry forums frequently discussing "diol-based polymer additives." Recent studies highlight its potential in biodegradable plasticizers, addressing environmental concerns reflected in search terms like "sustainable plastic additives."

Supply chain dynamics for CAS No. 56552-80-8 show growing preference for regional sourcing and just-in-time inventory models. Quality certifications such as ISO 9001 and REACH compliance dominate purchaser inquiries, alongside technical questions about storage stability (recommended under nitrogen at -20°C). The compound's hygroscopic nature necessitates specialized packaging solutions frequently searched as "moisture-sensitive chemical handling."

Emerging research explores continuous flow chemistry applications of this diol derivative, with publications citing improved atom economy in multistep syntheses. This aligns with academic searches for "flow reactor chiral intermediates." Computational chemistry studies utilizing DFT calculations predict its conformational behavior, meeting interest in "molecular modeling for diol compounds."

Market analysis indicates steady growth for chiral auxiliaries like (2R)-3-(benzyloxy)propane-1,2-diol, driven by demand for single-enantiomer drugs. Industry reports frequently benchmark it against similar C3 building blocks, with comparative data on enantiomeric excess (>98% typical) being a key purchasing criterion. Technical bulletins emphasize column chromatography purification methods for scale-up production.

Environmental fate studies confirm the compound's ready biodegradability under OECD 301 standards, responding to ecological concerns in chemical searches. Its low bioaccumulation potential makes it preferable for green manufacturing initiatives. Safety documentation highlights standard PPE requirements (gloves, goggles) without significant handling restrictions.

Future applications may leverage its hydrogen bonding capacity in supramolecular chemistry and organocatalysis, areas generating increasing scholarly attention. The compound's structural modularity allows benzyl group manipulation, enabling diverse downstream transformations frequently explored in recent synthetic methodology publications.

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