• 1. An amorphous lanthanum–iridium solid solution with an open structure for efficient water splitting?
  Wei Sun,Chenglong Ma,Xinlong Tian,Jianjun Liao,Ji Yang,Chengjun Ge,Weiwei Huang J. Mater. Chem. A, 2020,8, 12518-12525
• 2. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 3. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 4. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

Comprehensive Analysis of 1-(5-Ethoxy-2-hydroxyphenyl)ethanone (CAS No. 56414-14-3): Properties, Applications, and Industry Trends

1-(5-Ethoxy-2-hydroxyphenyl)ethanone (CAS No. 56414-14-3), also referred to as 5-Ethoxy-2-hydroxyacetophenone, is a versatile organic compound with a molecular formula of C₁₀H₁₂O₃. This aromatic ketone derivative has garnered significant attention in pharmaceutical, cosmetic, and specialty chemical industries due to its unique structural features and functional groups. The compound's ethoxy and hydroxyl substituents contribute to its solubility in polar solvents, making it valuable for synthetic applications.

In recent years, the demand for high-purity intermediates like 1-(5-Ethoxy-2-hydroxyphenyl)ethanone has surged, driven by advancements in drug discovery and green chemistry. Researchers frequently search for "CAS 56414-14-3 solubility" or "5-Ethoxy-2-hydroxyacetophenone synthesis," reflecting its role in optimizing reaction pathways. The compound's UV-absorbing properties also align with growing interest in natural sunscreen additives, as consumers increasingly seek eco-friendly cosmetic ingredients.

The pharmacological potential of 56414-14-3 is another hot topic. Studies suggest its derivatives may exhibit antioxidant and anti-inflammatory activities, correlating with searches for "phenolic ketones in medicine." Its structural similarity to flavonoid precursors makes it relevant to nutraceutical research, addressing trends in functional food formulations. Analytical techniques such as HPLC purification and NMR characterization are often discussed in relation to this compound.

From an industrial perspective, 1-(5-Ethoxy-2-hydroxyphenyl)ethanone serves as a key intermediate in synthesizing fine chemicals. Manufacturers emphasize batch-to-batch consistency, with queries like "CAS 56414-14-3 suppliers" highlighting supply chain considerations. The compound's thermal stability (typically stable below 200°C) and crystallinity make it suitable for scale-up processes, a critical factor for contract research organizations (CROs).

Environmental concerns have spurred interest in sustainable production methods for 56414-14-3. Recent patents describe catalytic ethoxylation routes that reduce waste, aligning with green chemistry principles. These innovations respond to searches for "biodegradable aromatic ketones" and "solvent-free synthesis," reflecting broader industry shifts toward circular economy practices.

Quality control remains paramount when working with 1-(5-Ethoxy-2-hydroxyphenyl)ethanone. Common analytical challenges include isomeric purity verification, as the compound may form regioisomers during synthesis. Laboratories frequently employ mass spectrometry (MS) and chromatographic methods to ensure compliance with ICH guidelines, particularly for pharmaceutical-grade material.

Emerging applications in material science further expand the relevance of CAS 56414-14-3. Its incorporation into polymeric coatings demonstrates improved weather resistance, addressing queries about "aromatic ketones in advanced materials." This interdisciplinary potential underscores why the compound remains a focus of academic research, with over 50 peer-reviewed publications referencing its properties since 2020.

For researchers exploring structure-activity relationships, the electron-donating effects of the ethoxy group in 5-Ethoxy-2-hydroxyacetophenone provide valuable insights. Computational chemistry studies often cite this compound when modeling hydrogen bonding interactions or molecular docking scenarios, making it a benchmark molecule in cheminformatics databases.

Regulatory compliance for 1-(5-Ethoxy-2-hydroxyphenyl)ethanone varies by region, with most jurisdictions classifying it as a non-hazardous chemical. However, proper handling protocols (e.g., PPE usage) are recommended due to potential dust irritation. Safety data sheets emphasize ventilation requirements and inert atmosphere storage for bulk quantities.

The future outlook for CAS 56414-14-3 appears promising, particularly in personalized medicine and smart materials. As synthetic biology advances, enzymatic production of such chiral intermediates may become feasible, answering searches for "bio-based acetophenone derivatives." Continued innovation will likely cement its status as a multipurpose building block in 21st-century chemistry.

• 14869-39-7(α-Ethoxyacetophenone)
• 33675-61-5(Ethanone,1-(2,6-diethoxyphenyl)-)
• 2142-67-8(2'-Ethoxyacetophenone)
• 2750-25-6(1-(2-ethoxy-6-hydroxyphenyl)ethan-1-one)
• 1201-38-3(2',5'-Dimethoxyacetophenone)
• 705-15-7(2-Hydroxy-5-methoxyacetophenone)
• 15889-70-0(Methanone,(4-ethoxy-2-hydroxyphenyl)phenyl-)
• 121704-77-6(1-(3-Propoxyphenyl)ethanone)
• 112434-80-7(1-(2,5-diethoxyphenyl)ethan-1-one)
• 22924-18-1(2',4'-Diethoxyacetophenone)