• 1. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 2. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller
• 3. Distinct impact of glycation towards the aggregation and toxicity of murine and human amyloid-β?
  Eunju Nam,Jiyeon Han,Sunhee Choi,Mi Hee Lim Chem. Commun., 2021,57, 7637-7640
• 4. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 5. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acids

Chemical Profile of 4-(difluoromethyl)benzoic acid (CAS No. 55805-21-5)

4-(difluoromethyl)benzoic acid, identified by the Chemical Abstracts Service Number (CAS No.) 55805-21-5, is a significant compound in the realm of pharmaceutical and chemical research. This benzoic acid derivative features a difluoromethyl substituent at the para position of the benzene ring, which imparts unique electronic and steric properties to the molecule. The presence of fluorine atoms enhances the lipophilicity and metabolic stability of the compound, making it a valuable scaffold in drug design and development.

The difluoromethyl group is a well-documented pharmacophore in medicinal chemistry, contributing to the bioactivity of numerous therapeutic agents. Its incorporation into benzoic acid derivatives has been explored for its potential in modulating enzyme inhibition and receptor binding affinity. Recent studies have highlighted the role of 4-(difluoromethyl)benzoic acid in the synthesis of novel antimicrobial and anti-inflammatory agents, leveraging its structural versatility.

In the context of modern drug discovery, 4-(difluoromethyl)benzoic acid serves as a key intermediate in the preparation of fluorinated heterocycles, which are increasingly recognized for their enhanced pharmacokinetic profiles. The compound’s ability to participate in palladium-catalyzed cross-coupling reactions further expands its utility in constructing complex molecular architectures. Researchers have utilized this precursor to develop inhibitors targeting bacterial enzymes, demonstrating its importance in combating resistant pathogens.

One notable application of 4-(difluoromethyl)benzoic acid is in the synthesis of protease inhibitors, where the difluoromethyl group plays a critical role in optimizing binding interactions with biological targets. The compound’s structural motif has been integrated into molecules designed for treating neurological disorders, showcasing its adaptability across diverse therapeutic areas. The growing interest in fluorinated compounds underscores the need for efficient synthetic routes to 4-(difluoromethyl)benzoic acid, driving innovation in catalytic methods and green chemistry approaches.

Advances in computational chemistry have also facilitated the exploration of 4-(difluoromethyl)benzoic acid as a building block for virtual screening campaigns. Molecular docking studies suggest its potential as an antagonist for certain G protein-coupled receptors, opening avenues for treating metabolic diseases and neurodegenerative conditions. The compound’s electronic properties, influenced by the electron-withdrawing nature of the carboxylic acid and fluorine substituents, make it an attractive candidate for designing photoactive materials and optoelectronic devices.

The industrial production of 4-(difluoromethyl)benzoic acid has seen significant improvements, with continuous-flow reactors enhancing yield and purity while reducing environmental impact. These innovations align with global efforts to sustainable chemical manufacturing, ensuring that high-quality intermediates like this one are accessible for research and commercial applications. Collaborative efforts between academia and industry have further accelerated the development of novel derivatives, reinforcing the compound’s role as a cornerstone in synthetic organic chemistry.

Looking ahead, the integration of 4-(difluoromethyl)benzoic acid into next-generation therapeutics will likely benefit from interdisciplinary approaches combining organic synthesis with bioinformatics. The compound’s versatility as a scaffold for functionalization offers endless possibilities for creating next-generation therapeutics with improved efficacy and reduced side effects. As research progresses, we can anticipate more breakthroughs emanating from this versatile molecule, solidifying its position as a pivotal player in pharmaceutical innovation.

• 455-24-3(4-(Trifluoromethyl)benzoic acid)
• 117186-02-4(3-Methyl-5-(trifluoromethyl)benzoic Acid)
• 454-92-2(3-(Trifluoromethyl)benzoic acid)
• 725-89-3(3,5-Bis(trifluoromethyl)benzoic acid)
• 55805-20-4(3-(Difluoromethyl)benzoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)