• 1. N-halogeno-compounds. Part 3. N-Chlorination of some fluorinated aryl- and heteroaryl-amines and anilides
  Ronald E. Banks,Michael G. Barlow,Timothy J. Noakes,Mohamad M. Saleh J. Chem. Soc. Perkin Trans. 1 1977 1746
• 2. Partially fluorinated heterocyclic compounds. Part I. The preparation of some tetra- and tri-fluoroquinolines, and some reactions of 5,6,7,8-tetrafluoroquinoline
  G. M. Brooke,W. K. R. Musgrave,R. J. D. Rutherford J. Chem. Soc. C 1966 215
• 3. Overcharge protection of lithium-ion batteries above 4 V with a perfluorinated phenothiazine derivative
  Aman Preet Kaur,Matthew D. Casselman,Corrine F. Elliott,Sean R. Parkin,Chad Risko,Susan A. Odom J. Mater. Chem. A 2016 4 5410
• 4. Rearrangement reactions of bicyclic systems. Part II. Rearrangements of 1-dimethylamino-5,6,7,8-tetrahalogeno-1,4-dihydro-1,4-ethenonaphthalene derivatives and the analogous 5,6,7,8-tetrafluoro-1,4-dihydro-N-methyl-1,4-iminonaphthalene in aqueous solutions
  Harry Heaney,Steven V. Ley J. Chem. Soc. Perkin Trans. 1 1974 2698
• 5. Fluoroaryl-substituted aminoalane dimers: syntheses and structures
  Piyush Shukla,Alan H. Cowley,Jamie N. Jones,John C. Gordon,Brian L. Scott Dalton Trans. 2005 1019

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aniline and substituted anilines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

2,3,4,5-Tetrafluoroaniline: A Comprehensive Overview

The compound 2,3,4,5-Tetrafluoroaniline, also known by its CAS number 5580-80-3, is a highly fluorinated aromatic amine that has garnered significant attention in the fields of organic chemistry and materials science. This compound is characterized by its unique structure, which features four fluorine atoms attached to a benzene ring with an amino group. The presence of multiple fluorine atoms imparts distinct chemical and physical properties to the molecule, making it a valuable compound for various applications.

Recent studies have highlighted the potential of 2,3,4,5-Tetrafluoroaniline in the development of advanced materials. For instance, researchers have explored its use as a precursor for synthesizing fluorinated polymers and high-performance composites. These materials exhibit exceptional thermal stability and chemical resistance, making them suitable for applications in aerospace and electronics industries. Additionally, the compound has been investigated for its role in drug design and development due to its ability to modulate biological activity through fluorination.

The synthesis of 2,3,4,5-Tetrafluoroaniline typically involves multi-step processes that include nucleophilic aromatic substitution and fluorination reactions. Recent advancements in catalytic methods have enabled more efficient and environmentally friendly routes for its production. For example, the use of transition metal catalysts has significantly improved the yield and selectivity of these reactions. Such innovations are crucial for scaling up production to meet the growing demand for this compound in various industries.

In terms of applications, 2,3,4,5-Tetrafluoroaniline has found utility in the synthesis of agrochemicals and pharmaceutical intermediates. Its ability to undergo various functional group transformations makes it a versatile building block in organic synthesis. Moreover, the compound has been employed in the development of novel sensors and imaging agents due to its unique electronic properties. Recent research has demonstrated its potential as a fluorescent probe for detecting specific analytes in complex biological systems.

The chemical properties of 2,3,4,5-Tetrafluoroaniline are heavily influenced by the electron-withdrawing nature of the fluorine atoms. This results in increased acidity of the amino group and enhanced reactivity towards electrophilic substitution reactions. These properties make it an attractive candidate for designing new materials with tailored functionalities. For instance, researchers have utilized its reactivity to develop novel polymeric materials with improved mechanical and thermal properties.

In conclusion, 2,3,4,5-Tetrafluoroaniline (CAS No: 5580-80-3) is a versatile compound with a wide range of applications across various scientific disciplines. Its unique structure and chemical properties make it an invaluable tool in organic synthesis and materials science. As research continues to uncover new potential uses for this compound

• 367-34-0(2,4,5-Trifluoroaniline)
• 700-17-4(2,3,5,6-Tetrafluoroaniline)
• 771-60-8(2,3,4,5,6-Pentafluoroaniline)
• 4519-40-8(2,3-Difluoroaniline)
• 67815-56-9(2,3,6-Trifluoroaniline)
• 363-80-4(2,3,5-Trifluoroaniline)
• 153505-39-6(1,2-Diamino-3,4-difluorobenzene)
• 1146-66-3(2-Aminoheptafluoronaphthalene)
• 3862-73-5(benzenamine, 2,3,4-trifluoro-)
• 363-73-5(2,3,4,6-Tetrafluoroaniline)