Cas no 55774-30-6 (5-fluoro-1-(2S)-oxolan-2-yl-1,2,3,4-tetrahydropyrimidine-2,4-dione)

5-Fluoro-1-(2S)-oxolan-2-yl-1,2,3,4-tetrahydropyrimidine-2,4-dione is a fluorinated pyrimidine derivative with a tetrahydrofuran (oxolane) substituent at the N1 position. This compound exhibits structural features that enhance its potential utility in medicinal chemistry, particularly as a nucleoside analog precursor. The fluorine substitution at the 5-position improves metabolic stability and bioavailability, while the (2S)-oxolan-2-yl group contributes to stereochemical specificity, which may influence binding interactions in biological systems. Its tetrahydropyrimidine-2,4-dione core is a key pharmacophore in antiviral and anticancer agents, suggesting applications in targeted drug development. The compound's well-defined stereochemistry and functional group arrangement make it a valuable intermediate for synthetic and biochemical research.
5-fluoro-1-(2S)-oxolan-2-yl-1,2,3,4-tetrahydropyrimidine-2,4-dione structure
55774-30-6 structure
Product Name:5-fluoro-1-(2S)-oxolan-2-yl-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS No:55774-30-6
MF:C8H9FN2O3
MW:200.167065382004
MDL:MFCD01677041
CID:370428
PubChem ID:148755
Update Time:2025-05-28

5-fluoro-1-(2S)-oxolan-2-yl-1,2,3,4-tetrahydropyrimidine-2,4-dione Chemical and Physical Properties

Names and Identifiers

    • 2,4(1H,3H)-Pyrimidinedione,5-fluoro-1-[(2S)-tetrahydro-2-furanyl]-
    • (S)-Ftorafur
    • 5-fluoro-1-(2S)-oxolan-2-yl-1,2,3,4-tetrahydropyrimidine-2,4-dione
    • (S)-tegafur
    • S-Ftorafur
    • 2,4(1H,3H)-PYRIMIDINEDIONE, 5-FLUORO-1-((2S)-TETRAHYDRO-2-FURANYL)-
    • (S)-5-Fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
    • 5-fluoro-1-[(2S)-oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
    • 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-, (S)-
    • CHEMBL3272485
    • 5-fluoro-1-[(2S)-oxolan-2-yl]pyrimidine-2,4-dione
    • (S)-1-(TETRAHYDROFURAN-2-YL)-5-FLUOROURACIL
    • UNII-4D5LOR404U
    • S-1-(Tetrahydrofuran-2-yl)-5-fluorouracil
    • EN300-8671643
    • NS00099073
    • SCHEMBL7698456
    • Uracil, 5-fluoro-1-(tetrahydro-2-furyl)-, (S)-
    • 4D5LOR404U
    • 5-fluoro-1-[(2S)-tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione
    • 55774-30-6
    • Tegafur, (S)-
    • Q27259434
    • MDL： MFCD01677041
    • Inchi： 1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)/t6-/m0/s1
    • InChI Key： WFWLQNSHRPWKFK-LURJTMIESA-N
    • SMILES： FC1C(NC(N(C=1)[C@@H]1CCCO1)=O)=O

Computed Properties

  • Exact Mass: 200.05977
  • Monoisotopic Mass: 200.06
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 1
  • Complexity: 316
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: _0.3
  • Topological Polar Surface Area: 58.6A^2

Experimental Properties

  • Density: 1.45
  • Boiling Point: °Cat760mmHg
  • Flash Point: °C
  • Refractive Index: 1.557
  • PSA: 58.64

5-fluoro-1-(2S)-oxolan-2-yl-1,2,3,4-tetrahydropyrimidine-2,4-dione Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Chemenu
CM580916-100mg
5-fluoro-1-[(2S)-oxolan-2-yl]pyrimidine-2,4-dione
 55774-30-6 95%+
100mg
 $4900 2023-02-02
Chemenu
CM580916-1g
5-fluoro-1-[(2S)-oxolan-2-yl]pyrimidine-2,4-dione
 55774-30-6 95%+
1g
 $8820 2023-02-02
Enamine
EN300-8671643-0.05g
5-fluoro-1-[(2S)-oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
 55774-30-6 95.0%
0.05g
 $2755.0 2025-03-21

5-fluoro-1-(2S)-oxolan-2-yl-1,2,3,4-tetrahydropyrimidine-2,4-dione Related Literature

55774-30-6 (5-fluoro-1-(2S)-oxolan-2-yl-1,2,3,4-tetrahydropyrimidine-2,4-dione) Related Products

Recommended suppliers
Yunnanjiuzhen
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Yunnanjiuzhen
Henan Dongyan Pharmaceutical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Henan Dongyan Pharmaceutical Co., Ltd
TAIXING JOXIN BIO-TEC CO.,LTD.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
TAIXING JOXIN BIO-TEC CO.,LTD.
Suzhou Genelee Bio-Technology Co., Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Suzhou Genelee Bio-Technology Co., Ltd.
煙臺(tái)朗裕新材料科技有限公司
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent