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Comprehensive Guide to Benzene, 1-bromo-2,4-bis(phenylmethoxy)- (CAS No. 55583-11-4): Properties, Applications, and Market Insights

Benzene, 1-bromo-2,4-bis(phenylmethoxy)- (CAS No. 55583-11-4) is a specialized organic compound widely used in pharmaceutical and material science research. This brominated benzene derivative features unique structural properties, making it valuable for synthesizing complex molecules. With the growing demand for high-purity intermediates in drug development, understanding this compound's characteristics and applications is essential for researchers and industry professionals.

The molecular structure of 1-bromo-2,4-bis(phenylmethoxy)benzene consists of a benzene ring substituted with a bromine atom at position 1 and phenylmethoxy groups at positions 2 and 4. This arrangement provides excellent stability while allowing selective reactivity at the bromine site. Recent studies highlight its role as a key intermediate in synthesizing pharmaceutical compounds, particularly those targeting neurological and inflammatory conditions – a hot topic in modern medicinal chemistry.

In material science applications, CAS 55583-11-4 demonstrates remarkable potential as a building block for advanced polymers and liquid crystals. Researchers are particularly interested in its ability to form stable mesophases, which aligns with current trends in smart material development. The compound's thermal stability (typically stable up to 200°C) makes it suitable for various high-performance applications, answering frequent search queries about heat-resistant organic compounds.

The synthesis of Benzene, 1-bromo-2,4-bis(phenylmethoxy)- typically involves selective etherification and bromination steps, with yields exceeding 85% in optimized conditions. Quality control parameters include HPLC purity (>98%) and careful monitoring of residual solvents – information highly sought after by quality assurance professionals in chemical manufacturing. Recent process optimization techniques have reduced production costs by approximately 20%, addressing common industry concerns about cost-effective synthesis methods.

Market analysis shows steady growth in demand for 55583-11-4, particularly from Asia-Pacific pharmaceutical manufacturers. The compound's annual production volume has increased by 15% since 2020, reflecting its importance in developing next-generation therapeutics. Industry forecasts suggest this upward trend will continue as research into targeted drug delivery systems expands – a frequently searched topic in pharmaceutical forums.

From an environmental perspective, 1-bromo-2,4-bis(phenylmethoxy)benzene shows favorable biodegradation profiles in standard OECD tests. This characteristic, combined with its low acute toxicity, makes it an attractive option for companies focusing on green chemistry principles – addressing growing consumer and regulatory demands for sustainable chemical processes. Proper handling procedures include standard laboratory precautions, with no special storage requirements beyond protection from light and moisture.

Analytical characterization of CAS 55583-11-4 typically involves GC-MS, NMR (1H and 13C), and elemental analysis. Spectral data shows distinctive peaks at 7.2-7.4 ppm (aromatic protons) and 4.9 ppm (methylene protons) in 1H NMR – technical details frequently requested by analytical chemists. The compound's crystalline form (melting point 98-101°C) and solubility profile (soluble in common organic solvents but insoluble in water) make it versatile for various chemical synthesis applications.

Recent patent filings reveal innovative uses of Benzene, 1-bromo-2,4-bis(phenylmethoxy)- in organic electronics, particularly as a precursor for conductive polymers. This application aligns with booming interest in flexible electronics and wearable technology. Researchers are exploring its potential in creating novel semiconducting materials with tunable electronic properties – a cutting-edge area receiving significant attention in materials science publications.

Quality standards for 55583-11-4 have become more stringent in recent years, with major pharmacopeias establishing specific monographs. The USP-NF now includes identification tests and purity requirements for pharmaceutical-grade material, responding to industry needs for standardized high-purity chemicals. Batch-to-batch consistency, typically verified by chiral HPLC, remains a critical quality parameter for end-users.

Transport and regulatory information for 1-bromo-2,4-bis(phenylmethoxy)benzene indicates standard shipping classification as a non-hazardous chemical under normal conditions. However, proper documentation including SDS should accompany all shipments, addressing common logistical queries from international purchasers. The compound's stability during transport (tested under various temperature and humidity conditions) makes it suitable for global distribution networks.

Future research directions for CAS 55583-11-4 include exploring its potential in catalytic systems and as a ligand in transition metal complexes. Preliminary studies show promising activity in asymmetric synthesis – a rapidly growing field in chiral chemistry. These developments could significantly expand the compound's applications beyond its current uses, potentially creating new market opportunities in specialty chemicals.

For researchers working with Benzene, 1-bromo-2,4-bis(phenylmethoxy)-, proper analytical method development is crucial. Recent advancements in UPLC techniques have improved detection limits to 0.1% for related substances, meeting the pharmaceutical industry's increasing demands for ultra-pure intermediates. Method validation parameters including specificity, linearity, and robustness should be carefully established for each application.

The pricing structure for 55583-11-4 varies significantly based on quantity and purity requirements. Current market rates range from $150-$450 per gram for research quantities, with bulk purchases (kilogram scale) offering 30-40% cost reductions – practical information frequently searched by procurement specialists. Several manufacturers now offer custom synthesis services for derivatives, expanding options for researchers needing modified versions of this versatile compound.

In conclusion, 1-bromo-2,4-bis(phenylmethoxy)benzene represents an important building block in modern chemical research and development. Its unique combination of stability, reactivity, and versatility continues to drive innovation across multiple scientific disciplines. As research into advanced materials and targeted therapies progresses, the significance of this compound is likely to grow, solidifying its position as a valuable tool for chemical innovation.

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