Cas no 5464-28-8 ((1,3-Dioxolan-4-yl)methanol)

(1,3-Dioxolan-4-yl)methanol is a versatile cyclic acetal alcohol with the molecular formula C?H?O?. It features a dioxolane ring structure with a hydroxymethyl substituent, offering reactivity at both the hydroxyl group and the acetal functionality. This compound is particularly valuable as a protected form of glycerol or glycolaldehyde in synthetic chemistry, enabling selective transformations under mild conditions. Its stability under basic and neutral conditions, combined with its ability to undergo acid-catalyzed ring-opening, makes it a useful intermediate in organic synthesis, pharmaceuticals, and polymer chemistry. The polar nature of (1,3-Dioxolan-4-yl)methanol also enhances its solubility in common organic solvents, facilitating its application in multistep synthetic routes.
(1,3-Dioxolan-4-yl)methanol structure
(1,3-Dioxolan-4-yl)methanol structure
Product Name:(1,3-Dioxolan-4-yl)methanol
CAS No:5464-28-8
MF:C4H8O3
MW:104.104521751404
MDL:MFCD00003218
CID:45914
Update Time:2026-05-14

(1,3-Dioxolan-4-yl)methanol Chemical and Physical Properties

Names and Identifiers

    • (1,3-Dioxolan-4-yl)methanol
    • glycerol 1,2-methylene ether
    • 4-hydroxymethyl-1,3-dioxolan
    • 1,3-Dioxolane-4-methanol
    • 1,3-dioxolan-4-ylmethanol
    • 1,3-Dioxolan-4-yl-methanol
    • Sericosol-N
    • Glycerin formal
    • 4-(Hydroxymethyl)-1,3-dioxolane
    • Glycerol, 1,2-O-methylene-
    • 1,2-(Methylidene)glycerol
    • BOHGAOWOIJMTPZ-UHFFFAOYSA-N
    • AK112875
    • Glycerol,2-O-methylene-
    • NCIOpen2_003665
    • [1,3]dioxolan-4-yl-methanol
    • 4-hydroxymet
    • MDL： MFCD00003218
    • Inchi： 1S/C4H8O3/c5-1-4-2-6-3-7-4/h4-5H,1-3H2
    • InChI Key： BOHGAOWOIJMTPZ-UHFFFAOYSA-N
    • SMILES： O1C([H])([H])OC([H])([H])C1([H])C([H])([H])O[H]
    • BRN： 0103187

Computed Properties

  • Exact Mass: 104.04700
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 7
  • Rotatable Bond Count: 1
  • Complexity: 54.9
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: -0.8
  • Topological Polar Surface Area: 38.7

Experimental Properties

  • Color/Form: liquid
  • Density: 1.203
  • Melting Point: 192-193 oC
  • Boiling Point: 192-193°C at 760 mmHg
  • Flash Point: 170?°F
  • Refractive Index: 1.425
  • PSA: 38.69000
  • LogP: -0.64840
  • Solubility: Soluble in water, alcohol and chloroform.

(1,3-Dioxolan-4-yl)methanol Security Information

  • Signal Word：Warning
  • Hazard Statement： H227-H319
  • Warning Statement： P305+P351+P338
  • WGK Germany：3
  • Safety Instruction： S23-S24/25
  • FLUKA BRAND F CODES：3
  • Storage Condition：Inert atmosphere,2-8°C
  • Safety Term：S23-S24/25

(1,3-Dioxolan-4-yl)methanol Customs Data

  • HS CODE：2942000000
  • Customs Data：

    China Customs Code:

    2932999099

    Overview:

    2932999099. Other heterocyclic compounds containing only oxygen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(1,3-Dioxolan-4-yl)methanol Pricemore >>

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(1,3-Dioxolan-4-yl)methanol Related Literature

Additional information on (1,3-Dioxolan-4-yl)methanol

Comprehensive Analysis of (1,3-Dioxolan-4-yl)methanol (CAS No. 5464-28-8): Properties, Applications, and Industry Trends

(1,3-Dioxolan-4-yl)methanol (CAS No. 5464-28-8) is a versatile organic compound with a molecular formula of C4H8O3. This dioxolane derivative is characterized by its hydroxyl-functionalized structure, making it a valuable intermediate in synthetic chemistry. The compound's unique cyclic acetal moiety and hydroxymethyl group contribute to its reactivity, enabling diverse applications in pharmaceuticals, agrochemicals, and specialty chemicals.

Recent trends in green chemistry have increased interest in 5464-28-8 as a potential bio-based building block. Researchers are exploring its use in sustainable polymer synthesis, particularly for creating biodegradable materials with low environmental impact. The compound's ability to form stable heterocycles makes it attractive for developing novel drug delivery systems, addressing current market demands for controlled-release formulations.

From a physicochemical perspective, (1,3-Dioxolan-4-yl)methanol typically appears as a colorless to pale yellow liquid with moderate viscosity. Its boiling point range (typically 220-230°C) and solubility profile (miscible with most organic solvents but limited water solubility) make it particularly useful for organic synthesis applications. The dioxolane ring provides excellent stability under acidic conditions while remaining reactive to nucleophilic attack at the methanol position.

In pharmaceutical applications, this compound serves as a key precursor for chiral synthons, especially in the synthesis of antiviral agents and CNS-active compounds. Its structural features allow for efficient stereoselective transformations, meeting the growing need for enantiomerically pure pharmaceuticals. Current research focuses on its potential in protease inhibitor development, particularly for emerging therapeutic areas.

The agrochemical industry utilizes 5464-28-8 in developing crop protection agents with improved environmental profiles. Its heterocyclic structure contributes to enhanced systemic activity in plants while maintaining favorable ecotoxicological parameters. Manufacturers are increasingly adopting this compound in next-generation fungicides that address resistance issues in major crops.

From a commercial availability standpoint, (1,3-Dioxolan-4-yl)methanol is typically supplied with high purity grades (>98%) suitable for research and industrial applications. Storage recommendations generally include inert atmosphere protection and temperature-controlled conditions to maintain stability. Recent supply chain optimizations have improved accessibility for global markets, with particular growth in Asia-Pacific specialty chemical sectors.

Analytical characterization of this compound typically employs GC-MS techniques for purity assessment and NMR spectroscopy for structural confirmation. Advanced HPLC methods have been developed to monitor process impurities during large-scale production. These quality control measures ensure compliance with pharmaceutical-grade specifications when required for end-use applications.

Emerging applications in material science are exploring the compound's potential as a crosslinking agent for thermoset resins and polyurethane modifications. Its dual functionality enables the creation of high-performance coatings with improved adhesion and chemical resistance. These developments align with industry demands for advanced polymeric materials in automotive and aerospace sectors.

Environmental and regulatory aspects of 5464-28-8 have been thoroughly evaluated, with current data indicating favorable biodegradation potential under standard test conditions. The compound falls within acceptable ranges for industrial hygiene parameters, though standard personal protective equipment is recommended during handling. Recent REACH compliance assessments confirm its continued availability for European markets.

Future research directions for (1,3-Dioxolan-4-yl)methanol include exploring its role in ionic liquid formulations and electrolyte additives for energy storage applications. Preliminary studies suggest potential benefits in battery performance enhancement, particularly for lithium-ion systems. These innovative applications could significantly expand the compound's market potential in coming years.

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