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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives Benzoylpyrazoles

(5-Amino-1-Phenyl-1H-Pyrazol-4-yl)-Phenyl-Methanone (CAS No. 54606-37-0)

(5-Amino-1-Phenyl-1H-pyrazol-4-yl)-phenyl-methanone (CAS No. 54606-37-0) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, also known as 4-(Phenylamino)-1-(phenylcarbonyl)-1H-pyrazole, is characterized by its unique structural features, which include a pyrazole ring, an amino group, and a phenyl ketone moiety. These structural elements contribute to its potential as a lead compound for the development of novel therapeutic agents.

The chemical structure of (5-Amino-1-Phenyl-1H-pyrazol-4-yl)-phenyl-methanone is defined by its molecular formula, C₁₅H₁₃N₃O, and its molecular weight of 259.28 g/mol. The compound is typically synthesized through a series of well-documented chemical reactions, including the condensation of phenylhydrazine with benzoyl chloride followed by the introduction of an amino group. This synthetic route has been optimized to achieve high yields and purity, making it suitable for both laboratory-scale synthesis and industrial production.

Recent research has highlighted the potential of (5-Amino-1-Phenyl-1H-pyrazol-4-yl)-phenyl-methanone in various biological applications. Studies have shown that this compound exhibits significant anti-inflammatory properties, which are attributed to its ability to inhibit the production of pro-inflammatory cytokines such as TNF-alpha and IL-6. This makes it a promising candidate for the treatment of inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

In addition to its anti-inflammatory effects, (5-Amino-1-Phenyl-1H-pyrazol-4-yl)-phenyl-methanone has also been investigated for its potential as an anticancer agent. Preclinical studies have demonstrated that this compound can induce apoptosis in various cancer cell lines, including those derived from breast, lung, and colon cancers. The mechanism of action involves the modulation of key signaling pathways such as the PI3K/AKT and MAPK pathways, which are frequently dysregulated in cancer cells.

The pharmacokinetic properties of (5-Amino-1-Phenyl-1H-pyrazol-4-yl)-phenyl-methanone have also been studied in detail. Research has shown that it exhibits favorable oral bioavailability and a reasonable half-life, making it suitable for oral administration in preclinical models. These properties are crucial for the development of effective therapeutic agents that can be administered conveniently to patients.

In terms of safety, preliminary toxicological studies have indicated that (5-Amino-1-Phenyl-1H-pyrazol-4-yl)-phenyl-methanone is well-tolerated at therapeutic doses. However, further studies are needed to fully evaluate its long-term safety profile and potential side effects. These studies will be essential for advancing this compound through clinical trials and ultimately bringing it to market as a new therapeutic option.

The versatility of (5-Amino-1-Phenyl-1H-pyrazol-4-yl)-phenyl-methanone extends beyond its direct biological activities. It serves as an important building block in the synthesis of more complex molecules with diverse biological activities. For example, it can be used as a starting material for the preparation of derivatives with enhanced potency or selectivity for specific targets. This makes it a valuable tool in drug discovery and development efforts.

In conclusion, (5-Amino-1-Phenyl-1H-pyrazol-4-y)-phenyl-methanone (CAS No. 54606-37-) is a promising compound with a wide range of potential applications in medicinal chemistry and pharmaceutical research. Its unique structural features, combined with its favorable biological properties and pharmacokinetic profile, make it an attractive candidate for further investigation and development as a novel therapeutic agent.

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