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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Alpha amino acid esters
• Solvents and Organic Chemicals Organic Compounds Heterocyclic Compounds

Comprehensive Overview of Methyl 5-oxopyrrolidine-2-carboxylate (CAS No. 54571-66-3): Properties, Applications, and Industry Insights

Methyl 5-oxopyrrolidine-2-carboxylate (CAS No. 54571-66-3) is a versatile organic compound widely recognized for its role in pharmaceutical synthesis and specialty chemical applications. This ester derivative of pyrrolidine features a 5-oxo (γ-lactam) moiety and a methyl carboxylate group, making it a valuable intermediate in medicinal chemistry. Its molecular formula, C₆H₉NO₃, and structural uniqueness have garnered attention in research on bioactive molecules, peptide mimetics, and heterocyclic scaffolds.

In recent years, the demand for Methyl 5-oxopyrrolidine-2-carboxylate has surged due to its utility in designing small-molecule drugs targeting neurological and metabolic disorders. Researchers frequently explore its structure-activity relationships (SAR) to optimize drug candidates, particularly for GABA receptor modulators and enzyme inhibitors. The compound’s compatibility with green chemistry protocols—such as solvent-free reactions or catalytic hydrogenation—aligns with the industry’s shift toward sustainable synthesis.

From a technical perspective, CAS 54571-66-3 exhibits a melting point range of 80–85°C and moderate solubility in polar solvents like ethanol and DMSO. Its stability under inert conditions makes it suitable for multistep synthetic routes. Analytical techniques such as HPLC, NMR, and mass spectrometry are commonly employed for purity verification, addressing the stringent quality requirements of GMP manufacturing.

The compound’s relevance extends to cosmetic science, where it serves as a precursor for skin-conditioning agents. Studies highlight its potential in formulating anti-aging creams due to its mild exfoliating properties and compatibility with hyaluronic acid derivatives. This dual applicability in pharma and cosmetics underscores its cross-industry appeal.

Emerging trends in AI-driven drug discovery have further amplified interest in Methyl 5-oxopyrrolidine-2-carboxylate. Computational models leverage its structural data to predict ADMET profiles (absorption, distribution, metabolism, excretion, toxicity) of derivative compounds. Such applications align with frequent search queries like "pyrrolidine derivatives in drug design" or "CAS 54571-66-3 suppliers", reflecting its commercial and academic demand.

Regulatory compliance remains a critical consideration. While 54571-66-3 is not classified as hazardous under major chemical inventories (e.g., REACH, TSCA), proper handling protocols—including PPE and ventilation—are recommended during lab-scale use. Suppliers often provide technical data sheets (TDS) and certificates of analysis (CoA) to ensure transparency.

In conclusion, Methyl 5-oxopyrrolidine-2-carboxylate exemplifies the intersection of innovation and practicality in modern chemistry. Its adaptability across drug development, cosmeceuticals, and computational chemistry positions it as a compound of enduring significance. As research advances, its role in addressing global health challenges and sustainable production will likely expand, reinforcing its status as a cornerstone of synthetic organic chemistry.

• 4931-66-2(Methyl L-pyroglutamate)
• 61275-11-4(Hexanoic acid, 6-[[5-methoxy-1,5-dioxo-4-[(1-oxodecyl)amino]pentyl]amino]-, methyl ester, (S)- (9CI))
• 522638-99-9(2-Pyrrolidinyl, 2-(methoxycarbonyl)-5-oxo-)
• 132435-65-5(Methyl 5-oxopyrrolidin-1-ide-2-carboxylate;rhodium(2+))
• 37673-40-8(tetracosyl 5-oxo-L-prolinate)
• 66183-71-9(ethyl 5-oxopyrrolidine-2-carboxylate)
• 131796-58-2(DIRHODIUM (II) TETRAKIS(METHYL 2-PYRROLIDONE-5(S)-CARBOXYLATE)ACETONITRILE/2-PROPANOL COMPLEX)
• 85153-82-8(propyl 5-oxo-dl-prolinate)
• 64700-65-8(methyl (2R)-5-oxopyrrolidine-2-carboxylate)
• 85153-83-9(L-Proline, 5-oxo-,propyl ester)