• 1. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 2. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 3. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 4. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 5. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Anilides

Comprehensive Overview of 2-Bromo-N-(3-methylphenyl)acetamide (CAS No. 5439-17-8): Properties, Applications, and Industry Insights

2-Bromo-N-(3-methylphenyl)acetamide (CAS No. 5439-17-8) is a specialized organic compound widely recognized for its role in pharmaceutical and agrochemical research. This brominated acetamide derivative features a 3-methylphenyl group, which enhances its reactivity and selectivity in synthetic applications. With the growing demand for high-purity intermediates in drug discovery, this compound has garnered significant attention for its potential in targeted molecular synthesis and structure-activity relationship (SAR) studies.

The compound's molecular structure (C₉H₁₀BrNO) includes a bromoacetamide moiety, making it a versatile building block for N-alkylation reactions and heterocyclic ring formation. Researchers frequently employ it in the development of bioactive molecules, particularly in kinase inhibitor and antimicrobial agent design. Its crystallinity and solubility profile (soluble in DMSO, methanol) further facilitate laboratory-scale optimization.

Recent trends highlight its relevance in green chemistry initiatives. As industries prioritize sustainable synthesis, 2-Bromo-N-(3-methylphenyl)acetamide is being explored in catalyst-free reactions and microwave-assisted protocols to reduce organic waste. A 2023 study demonstrated its efficacy in atom-economic coupling reactions, aligning with ESG (Environmental, Social, Governance) benchmarks—a key focus area for investors and regulatory bodies.

From a commercial perspective, the compound's supply chain dynamics reflect broader challenges in fine chemical procurement. Manufacturers emphasize batch-to-batch consistency and HPLC-validated purity (>98%), addressing quality concerns raised in peer-reviewed journals. Analytical techniques like NMR spectroscopy (1H, 13C) and mass spectrometry are critical for verifying its structural integrity, as documented in Reaxys and SciFinder databases.

Emerging applications include its use in proteomics research, where it serves as a protein modification reagent due to its electrophilic bromo group. This aligns with the rising interest in post-translational modification (PTM) analysis—a hot topic in biopharmaceutical development. Additionally, its metal-chelating properties are being investigated for material science applications, particularly in coordination polymer design.

For researchers sourcing this material, understanding its storage conditions (recommended 2-8°C under inert atmosphere) and compatibility with common protecting groups is essential. Regulatory-compliant documentation, including REACH certification and SDS (Safety Data Sheet), ensures adherence to global laboratory safety standards—a frequent search query among procurement specialists.

In summary, 2-Bromo-N-(3-methylphenyl)acetamide (CAS No. 5439-17-8) represents a critical tool for modern organic synthesis, bridging academic innovation and industrial scalability. Its multifaceted utility continues to expand, driven by advancements in precision chemistry and molecular design automation—topics dominating current scientific discourse.

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