• 1. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 2. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 3. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 4. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 5. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters

Ethyl 4-Tert-Butylbenzoate (CAS No. 5406-57-5): An Overview of Its Properties, Applications, and Recent Research

Ethyl 4-Tert-Butylbenzoate (CAS No. 5406-57-5) is a versatile organic compound with a wide range of applications in the pharmaceutical, cosmetic, and chemical industries. This compound is characterized by its distinct chemical structure, which includes an ester group and a tert-butyl substituent on a benzene ring. The unique combination of these functional groups imparts specific physical and chemical properties that make it valuable for various industrial and research purposes.

The chemical formula of Ethyl 4-Tert-Butylbenzoate is C₁₂H₁₆O₂. It is a colorless to pale yellow liquid with a characteristic aromatic odor. The compound is soluble in most organic solvents but has limited solubility in water. These properties make it suitable for use in formulations where solubility and stability are critical factors.

In the pharmaceutical industry, Ethyl 4-Tert-Butylbenzoate has been explored for its potential as a fragrance component and flavoring agent. Its aromatic nature and stability make it an attractive choice for enhancing the sensory properties of various products. Recent studies have also investigated its potential as a solvent in drug delivery systems, where its ability to dissolve and stabilize active pharmaceutical ingredients (APIs) can improve the efficacy and bioavailability of medications.

In the cosmetic industry, Ethyl 4-Tert-Butylbenzoate is used as a fragrance ingredient in perfumes, lotions, and other personal care products. Its pleasant aroma and good solubility in common cosmetic solvents make it a popular choice for formulators. Additionally, its low toxicity and skin compatibility contribute to its safety profile in consumer products.

From a chemical synthesis perspective, Ethyl 4-Tert-Butylbenzoate can be prepared through the esterification of 4-tert-butylbenzoic acid with ethanol in the presence of an acid catalyst. This reaction is well-documented in the literature and can be optimized for large-scale production. The tert-butyl group on the benzene ring provides steric hindrance, which can influence the reactivity and selectivity of the compound in various chemical reactions.

Recent research has focused on the environmental impact of compounds like Ethyl 4-Tert-Butylbenzoate. Studies have shown that while it has low toxicity to aquatic organisms, its biodegradability is an important consideration for its use in consumer products. Efforts are ongoing to develop more sustainable and environmentally friendly alternatives or to improve the biodegradability of existing compounds through chemical modifications.

In the field of materials science, Ethyl 4-Tert-Butylbenzoate has been investigated for its potential as a plasticizer in polymer formulations. Its ability to enhance the flexibility and processability of polymers makes it a valuable additive in various applications, including coatings, adhesives, and elastomers. Recent advancements in polymer science have led to the development of novel materials that incorporate this compound to achieve specific performance characteristics.

The safety profile of Ethyl 4-Tert-Butylbenzoate has been extensively studied. It is generally considered safe for use in consumer products when used within recommended concentrations. However, like any chemical compound, it should be handled with appropriate precautions to avoid skin contact and inhalation. Safety data sheets (SDS) provide detailed information on handling, storage, and disposal practices to ensure user safety.

In conclusion, Ethyl 4-Tert-Butylbenzoate (CAS No. 5406-57-5) is a multifunctional compound with diverse applications across multiple industries. Its unique chemical structure and favorable properties make it an important component in pharmaceuticals, cosmetics, and materials science. Ongoing research continues to explore new uses and improvements for this versatile compound, ensuring its relevance in both current and future applications.

• 377731-29-8(5-tert-butyl-isophthalic acid monomethyl ester)
• 6315-10-2(2-(2-methoxyethoxy)ethyl 4-propan-2-ylbenzoate)
• 62171-57-7(Benzoic acid, 3-(1,1-dimethylethyl)-, ethyl ester)
• 22201-45-2(Benzoic acid,4-(1,1-dimethylethyl)-, anhydride with 4-(1,1-dimethylethyl)benzoic acid)
• 26537-19-9(4-tert-Butylbenzoic Acid Methyl Ester)
• 92279-83-9(Benzoic acid, 4-(1,1-dimethylethyl)-, 1,1-dimethylethyl ester)
• 94134-32-4(Benzoicacid, 4-(1,1-dimethylethyl)-, butyl ester)
• 64277-87-8(Methyl 3,5-Di-tert-butylbenzoate)
• 16308-65-9(5-tert-Butyl dimethylisophthalate)
• 19024-50-1(ethyl p-isopropylbenzoate)